5,247 research outputs found

    Application of the International IgA Nephropathy Prediction Tool one or two years post-biopsy

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    The International IgA Nephropathy (IgAN) Prediction Tool is the preferred method in the 2021 KDIGO guidelines to predict, at the time of kidney biopsy, the risk of a 50% drop in estimated glomerular filtration rate or kidney failure. However, it is not known if the Prediction Tool can be accurately applied after a period of observation post-biopsy. Using an international multi-ethnic derivation cohort of 2,507 adults with IgAN, we updated the Prediction Tool for use one year after biopsy, and externally validated this in a cohort of 722 adults. The original Prediction Tool applied at one-year without modification had a coefficient of variation (R2) of 55% and 54% and four-year concordance (C statistic) of 0.82 but poor calibration with under-prediction of risk (integrated calibration index (ICI) 1.54 and 2.11, with and without race, respectively). Our updated Prediction Tool had a better model fit with higher R2 (61% and 60%), significant increase in four-year C-statistic (0.87 and 0.86) and better four-year calibration with lower ICI (0.75 and 0.35). On external validation, the updated Prediction Tool had similar R2 (60% and 58%) and four-year C-statistics (both 0.85) compared to the derivation analysis, with excellent four-year calibration (ICI 0.62 and 0.56). This updated Prediction Tool had similar prediction performance when used two years after biopsy. Thus, the original Prediction Tool should be used only at the time of biopsy whereas our updated Prediction Tool can be used for risk stratification one or two years post-biopsy

    sj-docx-1-cjk-10.1177_20543581221089094 – Supplemental material for The Canadian Glomerulonephritis Registry (CGNR) and Translational Research Initiative: Rationale and Clinical Research Protocol

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    Supplemental material, sj-docx-1-cjk-10.1177_20543581221089094 for The Canadian Glomerulonephritis Registry (CGNR) and Translational Research Initiative: Rationale and Clinical Research Protocol by Ainslie M. Hildebrand, Moumita Barua, Sean J. Barbour, Karthik K. Tennankore, Daniel C. Cattran, Tomoko Takano, Ping Lam, Sacha A. De Serres, Ratna Samanta, Michelle A. Hladunewich, Todd Fairhead, Penelope Poyah, D. Danielle Bush, Brian MacLaren, Dwight Sparkes, Philip Boll, Arenn Jauhal, Rohan John, Carmen Avila-Casado and Heather N. Reich in Canadian Journal of Kidney Health and Disease</p

    The Family History Of Daniel C. Hodges

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    The Family History of Daniel C. Hodges 21 April 2018 Daniel Clayton Hodges authored this family history as part of the course requirements for HIST 550/700 Your Family in History offered online in Spring 2018 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected] This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

    Ethnic identity, political identity and ethnic conflict: simulating the effect of congruence between the two identities on ethnic violence and conflict

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    This thesis outlines and presents an alternative hypothetical process to the emergence of ethnic conflict. Ethnic conflicts, rather than being dependent upon pre-existing 'ancient hatreds', are instead the result of a congruence between ethnic and political identity which grants individuals the ability to use ethnicity to identify and eliminate political threats. This hypothesis is formed by the examination of three case studies of ethnic conflict: Lebanon, Northern Ireland and Croatia. This hypothesis is then formalised and tested using an agent based simulation in which agent interactions are dependent upon ethnic and political identity and the congruence between the two. As predicted there was a strong positive correlation between how accurately ethnic identity reflected political identity and the level of ethnically motivated violence in the simulation, although the relationship was not linear. Furthermore the effect of a shift in congruence was found to be roughly comparable to the effect of initialising agents with a moderate level of pre-existing ethnic antagonism

    Replication Data for: Interests, Information and Minority Influence in Deliberation

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    This data and code are to replicate the findings in "Interests, Information and Minority Influence in Deliberation." Please email the author at [email protected] or [email protected] with any questions

    Replication Data for: Interests, Information and Minority Influence in Deliberation

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    This data and code are to replicate the findings in "Interests, Information and Minority Influence in Deliberation." Please email the author at [email protected] or [email protected] with any questions

    Method of thermally glazing an article, U.S. Patent 6,127,005

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    Coating and filler materials for localized thermal processing of glazed ceramics and other brittle and low thermal conductivity materials. The coating materials include oxide compositions that exhibit coefficients of thermal expansion which are less than about 8×10-6 /° C. and glass transition temperatures which are less than about 400° C. The filler materials include particulate oxide materials which do not substantially react during localized thermal processing of glazed ceramics and other brittle and low thermal conductivity materials. The coating and filler materials are useable together as a composite material for repairing cavities having depths greater than about 2 mm

    Daniel C. Dennett’s Language of Consciousness

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    The paper discusses the lingual genesis of consciousness. The author reconstructs Daniel C. Dennett’s naturalization strategy, showing how, according to Dennett, language enables the emergence of consciousness in the evolution of humankind. This naturalization assumes a behavioristic view according to which consciousness is a covert verbal behavior. The author shows that Dennett adopts and transforms Mead’s, Skinner’s, and Jaynes’s original behavioristic approaches inscribing them into a course of human evolution. This inscription leads to specific problems discussed in the final part of the paper: There are actually two definitions of consciousness in Dennett’s philosophy — first says that consciousness is a kind of verbal behavior, second says that it is a virtual memetic machine. There is no explanation of the execution rule that could show how given mind content becomes conscious; Dennett introduces the competition metaphor instead. Some contentful events in the brain (mind contents) simply win with others. Inscription of the possible scenario of consciousness development in the evolutionary landscape does not mean that one can testify the theory yet

    Florida Historical Quarterly Podcast Episode 06: Summer 2010

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    We interviewed Gilbert C. Din, Professor Emeritus at Fort Lewis College in Durango, Colorado. He is the author of several books on colonial Louisiana and a frequent contributor to the FHQ. We interviewed him about his work on William August Bowles and about his article that appeared in this issue, titled “William August Bowles on the Gulf Coast, 1787-1803: Unraveling a Labyrinthine Conundrum.”https://stars.library.ucf.edu/fhq-podcast/1005/thumbnail.jp
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