9,159 research outputs found
Phosphoinositides in golgi complex function
No full textThe Golgi complex is a ribbon-like organelle composed of stacks of flat cisternae interconnected by tubular junctions. It occupies a central position in the endomembrane system as proteins and lipids that are synthesized in the endoplasmic reticulum (ER) pass through the Golgi complex to undergo biosynthetic modification (mainly glycosylation) and to be sorted to their final destinations. In addition the Golgi complex possesses a number of activities, apparently not directly connected with its main role in trafficking and sorting, which have been recently reviewed in Wilson et al. 2011. In spite of the constant massive flux of material the Golgi complex maintains its identity and phosphoinositides (PIs), among other factors, play a central role in this process. The active metabolism of PIs at the Golgi is necessary for the proper functioning of the organelle both in terms of membrane trafficking/sorting and its manifold metabolic and signalling activities. Phosphatidylinositol 4-phosphate (PtdIns4P), in particular, is responsible for the recruitment of numerous cytosolic proteins that recognise and bind PtdIns4P via specific lipid-binding domains. In this chapter we will summarize the findings that have contributed to our current understanding of the role of PIs in the biology of the Golgi complex in terms of the regulation of PI metabolism and the functional roles and regulation of PtdIns4P effectors
Person-centred advocacy: Some ethical issues
No full textIn the second of two articles on advocacy for people with dementia Mike Fox with Lesley Wilson considers some of the ethical issues arising from advocacy work within a residential home that was due to close
The Adventures Of Peregrine Pickle : In which are included, Memoirs Of A Lady Of Quality ; In Four Volumes
No full textVorlageform des Erscheinungsvermerks: London : Printed for the Author: And sold by D. Wilson, at Plato's Head, near Round-Court, in the Strand. MDCCLI
The Adventures Of Peregrine Pickle : In which are included, Memoirs Of A Lady Of Quality ; In Four Volumes
No full textVorlageform des Erscheinungsvermerks: London : Printed for the Author: And sold by D. Wilson, at Plato's Head, near Round-Court, in the Strand. MDCCLI
The Four Kings of the Forest: A Fable
No full textAlthough named a fable by the author/illustrator, this 20-page story reaches beyond the usual limits of a fable. It tells the story of four kings -- lion, elephant, gorilla, and snake -- who learn from a boy and make him a fifth king. Ingres mold-made paper with color lineoleum block prints. As Powell's description says, "The colors used and the illustrations are charming." Bound by green thread.Signed by Wilson, #244 of 275Joyce Lancaster Wilso
The Adventures Of Peregrine Pickle : In which are included, Memoirs Of A Lady Of Quality ; In Four Volumes
No full textVorlageform des Erscheinungsvermerks: London : Printed for the Author: And sold by D. Wilson, at Plato's Head, near Round-Court, in the Strand. MDCCLI
The Adventures Of Peregrine Pickle : In which are included, Memoirs Of A Lady Of Quality ; In Four Volumes
No full textVorlageform des Erscheinungsvermerks: London : Printed for the Author: And sold by D. Wilson, at Plato's Head, near Round-Court, in the Strand. MDCCLI
A study of rail transit system phasing and expansion decisions
No full textThesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1996.Includes bibliographical references (p. 169-173).by Cathal Tomás Ridge.M.S
From the Roman Republic to the American Revolution: readings of Cicero in the political thought of James Wilson
No full textAs a classical scholar and prominent founding father, James Wilson was at once statesman, judge, and political thinker, who read Cicero as an example worthy of emulation and as a philosopher whose theory could be applied to his own age. Classical reception studies have focused on questions of liberty, civic virtue, and constitutionalism in the American founding, and historians have also noted Wilson’s importance in American history and thought. Wilson’s direct engagement with Cicero’s works, however, and their significance in the formulation of his own philosophy has been long overlooked. My thesis argues that Wilson’s viewpoint was largely based on his readings of Cicero and can only be properly understood within this context. In the first two chapters of my thesis I demonstrate that Wilson not only possessed a wide-ranging knowledge of the classics in general, but also that he borrowed from Cicero’s writings and directly engaged with the texts themselves. Building upon this foundation, chapters three and four examine Cicero’s perspective on popular sovereignty and civic virtue, situate Wilson’s interpretations within contemporary discussions of Roman politics, and analyse the main ways in which he adapts Cicero’s arguments to his own era. Wilson retains a broader faith in the common people than seen in Cicero’s opinions, and he abstracts from Cicero a doctrine of sovereignty as an indivisible principle that is absent in the text; nevertheless, Cicero’s conception of a legitimate state and his insistence on the role of the people provided the foundation for Wilson’s thought and ultimately for his legitimization of the American Revolution. At the same time, like Cicero, Wilson views the stability of the state as resting in the personal virtue of the individual. While his enlightenment philosophy imparts optimism to his conception of the good citizen, his definition of virtue closely follows that of Cicero. As the final chapter of my thesis concludes, their individual interpretations of these theories of popular consent and virtue were instrumental in forming Cicero’s and Wilson’s justifications of civil disobedience
- …
