1,721,016 research outputs found
Cyclic GMP formation induced by muscarinic receptors is mediated by nitric oxide synthesis in rat cortical primary cultures
No full textThe results of this study deminstrated that the muscarinic receptor-stimulated cGMP formatipn in rat cerebral cortex is mediated by nitric oxide
Rat brain monoaminergic neurotransmission parameters after perinatal exposure to methylmercury and PCB153.
No full textMeHg-exposure through seafood consumption. Cholinergic muscarinic receptors as a target of toxicity and potential biomarkers of CNS effects.
No full textExposure to methylmercury and PCB153 during pregnancy and lactation. Effects on brain and lymphocyte cholinergic muscarinic receptors in rat dams and pups.
No full textInteraction of ethanol with muscarinic receptor-stimulated phosphoinositide during the brain growth spurt in the rat: role of acetaldehyde.
No full textThe results of this in vitro study suggest that ethanol itself, not the ethanol metabolite acetaldehyde may be the primary agent responsible for developmental neurotoxic effects associated with heavy alcohol consumption
Comparative in vitro ex-vivo myelotoxicity of aflatoxins B1 and M1 on haematopoietic progenitors (BFU-E, CFU-E, and CFU-GM): Species-related susceptibility.
No full textHaemato- and myelotoxicity are adverse effects caused by mycotoxins. Due to the relevance of aflatoxins to human health, the present study, employing CFU-GM-, BFU-E- and CFU-E-clonogenic assays, aimed at (i) comparing, in vitro, the sensitivity of human vs. murine haematopoietic progenitors to AFB1 and AFM1 (0.001–50 lg/ml), (ii) assessing whether a single AFB1 in vivo treatment (0.3–3 mg/kg b.w.) alters the ability of murine bone marrow cells to form myeloid and erythroid colonies, and (iii) comparing the in vitro with the in vitro ex-vivo data. We demonstrated (i) species-related sensitivity to AFB1, showing higher susceptibility of human myeloid
and erythroid progenitors (IC50 values: about 4 times lower in human than in murine cells), (ii) higher sensitivity of CFU-GM and BFU-E colonies, both more markedly affected, particularly by AFB1 (IC50: 2.45 ± 1.08 and 1.82 ± 0.8 lM for humans, and 11.08 ± 2.92 and 1.81 ± 0.20 lM for mice, respectively), than the mature CFU-E (AFB1 IC50: 12.58 ± 5.4 and 40.27 ± 6.05 lM), irrespectively of animal species, (iii) regarding AFM1, a species- and lineage-related susceptibility similar to that observed for AFB1 and (iv) lack of effects after AFB1 in vivo treatment on the proliferation of haematopoietic colonies
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