2,175 research outputs found
«Per un sapiente la Grecia è ovunque: non v’è paese deserto o barbaro». Tra Persia e India: la sophia itinerante di Apollonio di Tyana.
No full textAnna Casella Paltrinieri, ed, 2012, Incontri transatlantici: Il Brasile negli studi dell’antropologia italiana, Aprilia, Novalogos, pp. 350
Get PDFBook review of Anna Casella Paltrinieri, ed, 2012, Incontri transatlantici: Il Brasile negli studi dell’antropologia italiana, Aprilia, Novalogos, pp. 350.Recensione di Anna Casella Paltrinieri, ed, 2012, Incontri transatlantici: Il Brasile negli studi dell’antropologia italiana, Aprilia, Novalogos, pp. 350
Chiara Lubich, Meditazioni: letteratura come relazione
No full textChiara Lubich (1920–2008), although the author of 32 books published in 26 countries (178 editions, 3.2 million copies), is better known for her social engagement, as reflected in numerous awards. She began to be regarded as a literary author only in the early 2000s, and primarily from a linguistic rather than literary perspective. This article focuses on her book Meditazioni (Meditations), reconstructs its genesis by tracing the writing process from the late 1950s to her death and the 2021 critical edition, and offers a literary analysis. This reveals Lubich as a forerunner of a new conception of literature: literature as relationship – not only between author and reader, but also among subject, inspiration, and the editorial process
Icosapent ethyl: insights into cardiovascular residual risk
No full textEditorial on icosapent-ethyle utilization in clincial practic
Donne aristocratiche nel Friuli del Cinquecento tra strategie familiari e conflitti di fazione
No full textIl saggio discute la posizione dele donne nella storia politica del Friuli cinquecentesco attraverso l'analisi di tre casi in cui il ruolo femminile è letto all'interno delle più ampie strategie familiari, delle loro alleanze matrimoniali e politiche. Il ruolo di Elena d'Este legata alle casate dei Savorgnan e dei Della Torre; quello di Chiara Priuli e Bianca Giustinian, entrambe vedove Savorgnan; il caso di Venere Bosina, donna non nobile al centro di una rete parentale e di interessi economici che scavalca il confine veneto-arciducal
Oxidase Reactivity of CuII Bound to N-Truncated Aβ Peptides Promoted by Dopamine
No full textThe redox chemistry of copper(II) is strongly modulated by the coordination to amyloid-β peptides and by the stability of the resulting complexes. Amino-terminal copper and nickel binding motifs (ATCUN) identified in truncated Aβ sequences starting with Phe4 show very high affinity for copper(II) ions. Herein, we study the oxidase activity of [Cu–Aβ4−x] and [Cu–Aβ1−x] complexes toward dopamine and other catechols. The results show that the CuII–ATCUN site is not redox-inert; the reduction of the metal is induced by coordination of catechol to the metal and occurs through an inner sphere reaction. The generation of a ternary [CuII–Aβ–catechol] species determines the efficiency of the oxidation, although the reaction rate is ruled by reoxidation of the CuI complex. In addition to the N-terminal coordination site, the two vicinal histidines, His13 and His14, provide a second Cu-binding motif. Catechol oxidation studies together with structural insight from the mixed dinuclear complexes Ni/Cu–Aβ4−x reveal that the His-tandem is able to bind CuII ions independently of the ATCUN site, but the N-terminal metal complexation reduces the conformational mobility of the peptide chain, preventing the binding and oxidative reactivity toward catechol of CuII bound to the secondary site
A Cu-bis(imidazole) Substrate Intermediate Is the Catalytically Competent Center for Catechol Oxidase Activity of Copper Amyloid-β
No full textInteraction of copper ions with Aβ peptides alters the redox activity of the metal ion and can be associated with neurodegeneration. Many studies deal with the characterization of the copper binding mode responsible for the reactivity. Oxidation experiments of dopamine and related catechols by copper(II) complexes with the N-terminal amyloid-β peptides Aβ16 and Aβ9, and the Aβ16[H6A] and Aβ16[H13A] mutant forms, both in their free amine and N-acetylated forms show that efficient reactivity requires the oxygenation of a CuI-bis(imidazole) complex with a bound substrate. Therefore, the active intermediate for catechol oxidation differs from the proposed "in-between state" for the catalytic oxidation of ascorbate. During the catechol oxidation process, hydrogen peroxide and superoxide anion are formed but give only a minor contribution to the reaction
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