1,721,101 research outputs found

    Current issues in the scientific cooperation in Europe

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    The excessive bureaucracy and complexity of the Horizon calls appears to be an obstacle to research cooperation in Europe. Funding agencies of the European Union emphasize competitiveness, but do not recognize that publishing scientific papers increases competitiveness. Even the distribution of funds appears very far from recognizing the proper value of scientific publications. In this context, I am not surprised that some (not all) UK researchers have no confidence in European cooperative research

    The true challenges of the COVID-19 epidemics. The need for essential levels of care for all

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    In the last decades, biomedical research and funding supporting it have given a relevant impulse to developing so-called “Personalized Medicine” (PM) and “precision medicine”, leading to the discovery of treatments of unimaginable efficacy up to a few years ago. In most countries, care of excellence is only for those who can afford it, but even in countries with strong national health systems, the commitment to individualized care may have diverted resources and attention from creating systems that guarantee protection for all. Furthermore, the COVID-19 experience suggests that the impact and invasiveness of the epidemic could be amplified by the contagion of the population groups without assistance or with low-level assistance in rich nations and of low-income nations without a minimum health system. We must learn from this lesson that if we fail to guarantee a minimum support for everyone in terms of health services, prevention and treatment, we risk endangering everyone's health, not only that of people without privileges

    An evolutionist approach of mood disorders from a transcultural perspective | [Une approche évolutionniste de la manie dans une perspective transculturelle]

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    Introduction: The objective of this paper is to verify if traits and symptoms defined as pathological and maladjusted in certain contexts may produce adaptive effects in other contexts, especially if they occur in sub-threshold forms. Methods: A historical examination of how the symptoms of depression have changed in front of great social changes and an analysis of Sardinian migrants’ thymic profiles toward several metropolises. Results and conclusions: Mood disorders have been increasing since the “English malady” in the 17th century, and we suppose that some forms of mood disorders might have an adaptive advantage. Otherwise, the increase of such an epidemic would have been self-limited. From a sociobiological point of view, it is highly probable that the environment of a rapidly evolving society can select people who are explorers and able to support accelerated biorhythms and that the condition of social change stimulates psychological and psychopathologic changes. It is also possible that hyperthymic persons modulate and create the new environment. If this model can explain the epidemic of mood disorders, its verification should guide future research

    Coping with the new era: Noise and light pollution, hperactivity and steroid hormones. Towards an evolutionary view of bipolar disorders

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    Human population is increasing in immense cities with millions of inhabitants, in which life is expected to run 24 hours a day for seven days a week (24/7). Noise and light pollution are the most reported consequences, with a profound impact on sleep patterns and circadian biorhythms. Disruption of sleep and biorhythms has severe consequences on many metabolic pathways. Suppression of melatonin incretion at night and the subsequent effect on DNA methylation may increase the risk of prostate and breast cancer. A negative impact of light pollution on neurosteroids may also affect mood. People who carry the genetic risk of bipolar disorder may be at greater risk of full-blown bipolar disorder because of the impact of noise and light pollution on sleep patterns and circadian biorhythms. However, living in cities may also offers opportunities and might be selective for people with hyperthymic temperament, who may find themselves advantaged by increased energy prompted by increased stimulation produced by life in big cities. This might result in the spreading of the genetic risk of bipolar disorder in the coming decades. In this perspective the burden of poor quality of life, increased disability adjusted life years and premature mortality due to the increases of mood disorders is the negative side of a phenomenon that in its globality also shows adaptive aspects. The new lifestyle also influences those who adapt and show behaviors, reactions and responses that might resemble the disorder, but are on the adaptive side
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