405 research outputs found
Wilhelm Marr 1819–1904 jako „patriarcha” niemieckiego antysemityzmu
No full textWILHELM MARR 1819–1904 AS THE “PATRIARCH” OF GERMAN ANTI-SEMITISMWilhelm Marr 1819–1904, called “the patriarch of Anti-Semitism,” is the author of the neologism which has found its place in every language of the world, meaning the term Antisemitismus. He used it for the first time in his major book titled Der Sieg des Judenthum über das Germanenthum 1879. In the first part of this article the author puts forward a supposition that cultural pessimism Kulturpessimismus cannot be seen as a key to the understanding of Marr’s political thought even though his writings certainly subscribe to this viewpoint. Such an interpretation of Marr’s conceptions is negated by an intellectual provocation through which Marr, overemphasizing the humiliation of his compatriots “Vae Victis! Finis Germaniae!”, attempts to mobilize them for a relentless and uncompromising struggle for the homogeneous nation-state. In the following parts of the article the author presents Marr’s approach to the question of religion in a racial context and the latter’s opinions on the potential assimilation of “Israel” and some “dangers” apparently connected to this process. As an atheist and an empiricist Marr was unfavorably disposed towards religion. He mocked the Anti-Semitism of “previous ages” meaning Anti-Judaism and its accusations concerning the so-called Jewish Deicide Gottesmord, alleged ritual murders Ritualmorde or an alleged practice of stealing and desecrating the Host. He claimed that the true peril to the German element may be truly and rationally conceived only in racial categories. It was because of those reasons that Marr did not perceive any possibility of the integration of Jews into the German society. Simultaneously, Marr did not hesitate to praise Jews for the enterprising spirit and was even mentioning the natural Jewish right to self-defense. Marr expected that his work would be continued by Johannes Scherr 1817–1886, a historian of culture. However, contrary to his intentions, Marr’s thought was actually developed by his one-time student Theodor Fritsch 1852–1933, who was later conflicted with his master, in his works titled Antisemiten-Katechismus 1887 and Handbuch der Judenfrage 1907. At the moment of Fritsch’s exposition the German Anti-Semitism concluded its long way from “utopia” to “science.”WILHELM MARR 1819–1904 AS THE “PATRIARCH” OF GERMAN ANTI-SEMITISMWilhelm Marr 1819–1904, called “the patriarch of Anti-Semitism,” is the author of the neologism which has found its place in every language of the world, meaning the term Antisemitismus. He used it for the first time in his major book titled Der Sieg des Judenthum über das Germanenthum 1879. In the first part of this article the author puts forward a supposition that cultural pessimism Kulturpessimismus cannot be seen as a key to the understanding of Marr’s political thought even though his writings certainly subscribe to this viewpoint. Such an interpretation of Marr’s conceptions is negated by an intellectual provocation through which Marr, overemphasizing the humiliation of his compatriots “Vae Victis! Finis Germaniae!”, attempts to mobilize them for a relentless and uncompromising struggle for the homogeneous nation-state. In the following parts of the article the author presents Marr’s approach to the question of religion in a racial context and the latter’s opinions on the potential assimilation of “Israel” and some “dangers” apparently connected to this process. As an atheist and an empiricist Marr was unfavorably disposed towards religion. He mocked the Anti-Semitism of “previous ages” meaning Anti-Judaism and its accusations concerning the so-called Jewish Deicide Gottesmord, alleged ritual murders Ritualmorde or an alleged practice of stealing and desecrating the Host. He claimed that the true peril to the German element may be truly and rationally conceived only in racial categories. It was because of those reasons that Marr did not perceive any possibility of the integration of Jews into the German society. Simultaneously, Marr did not hesitate to praise Jews for the enterprising spirit and was even mentioning the natural Jewish right to self-defense. Marr expected that his work would be continued by Johannes Scherr 1817–1886, a historian of culture. However, contrary to his intentions, Marr’s thought was actually developed by his one-time student Theodor Fritsch 1852–1933, who was later conflicted with his master, in his works titled Antisemiten-Katechismus 1887 and Handbuch der Judenfrage 1907. At the moment of Fritsch’s exposition the German Anti-Semitism concluded its long way from “utopia” to “science.&rdquo
Musical history : as shown in the International Exhibition of Music and the Drama, Vienna 1892
No full textby Robert A. Marr, author of "Music and musicians", "Music for the people", and "The rise of choral societies in Scotland
Life on Marr\u27s; Historical Archaeology on Marr\u27s Island, Georgetown, Maine
No full textMost people have an interest in local history, usually driven by a passion for identifying themselves within the context of a certain time and place. Marr\u27s Island, in the Sagadahoc River in Georgetown, Maine, is one small place in an area with a long history. There is an archaeological site on the island consisting of a foundation and cellar of a house built in 1791. Historical archaeology is an effective approach in learning about life on the island. It is based on a combination of research techniques that utilize documentary evidence, material culture, and archaeological theory to interpret the past. This theis is a result of an archaeological investigation of the Marr\u27s Island Homstead site (ME 168-023) conducted between 2004 and 2005. The excavation of the five square meters resulted in the collection of over 5,000 artifacts. Historical evidence from land transactions, genealogy and census records combines with archaeological evidence of the Marr family\u27s occupation of the island to create an historical interpretation. This thesis demonstrates the author\u27s ability to interpret information from a variety of sources, and to create a history of a particular place in the light of a broader historical and archaeological context. The Marr family made two successive occupations on the island between 1791 and 1840. John Mars and family moved there because of the island\u27s access to marine resources. John relied on fishing for sustenance and income. He built a typical hall and parlor house, and appears to have been of middling economic status. His son Isiah lived in the house after John left in 1808. The Marrs purchased dometic and imported goods, displaying a preference for fashionable, if not expensive, stye of ceramics. Plagued by death, economic instability and drawn to opportunities for land and work on Georgetown Island, members of the Marr family abandoned their island homestead by 1840. They left behind an archaeological site, and a family cemetery. The homestead site remained relatively undisturbed, even when the current owners built upon it. It has escaped development and other disturbances, which is rare for coastal sites. Marr\u27s Island\u27s intact archaeological record offers valuable information about domestic life in Maine in the Federal Period
Any space left? Homeless resistance by place-type in Los Angeles County
No full textThis study develops a more nuanced concept of homeless resistance, incorporating a range of resistance behaviors (exit, adaptation, persistence, and voice) that bridge the gap between current frameworks that either romanticize or ignore it. We also consider the possibility that different kinds of space may theoretically allow for different kinds of resistance. To this end, we employ an ecological approach to homeless space by classifying Los Angeles County into three place-types (prime, transitional, and marginal). We empirically consider the issue of resistance within the hardening context among a group of 25 homeless informants, focusing on whether and how some of them have exercised their voices and sought to ameliorate one or more aspects of their situation, as well as how resistance may vary by place-type
Structural and mechanistic study of the cysteine oxidation-mediated induction of the Escherichia coli MarR regulator
No full textMultiple antibiotic resistance regulator (MarR) family proteins are widely conserved transcription factors that are important for regulating bacterial resistance to various stresses. Escherichia call MarR, the prototype member of this family, has recently been shown to undergo interdimer disulfide bond formation via a unique cysteine residue (Cys80) that ultimately triggered MarR's dissociation from its promoter DNA. However, these structural studies were performed with cysteine mutants while the structure of wild type MarR remains uncharacterized. Here we report the crystal structure of wild type MarR in the absence of DNA, which further revealed the roles of cysteine residues in MarR's transcriptional regulation. In addition, we developed a circularly permuted yellow fluorescent protein (cpYFP)based environmental-sensitive fluorescent reporter for in situ detection of the DNA-binding induced conformational change on MarR, which verified the induction mechanism of this prototypical MarR family protein. This strategy might potentially be applicable for monitoring local conformational change within diverse protein structures. (C) 2017 Elsevier Ltd. All rights reserved.National Natural Science Foundation of China [21432002, 21521003]; National Key Research and Development Program [2016YFA0501500]SCI(E)ARTICLE263714-37197
Molecular Mechanisms of Ligand-Mediated Attenuation of DNA Binding by MarR Family Transcriptional Regulators
No full textBacteria and archaea encode members of the large multiple antibiotic resistance regulator (MarR) family of transcriptional regulators. Generally, MarR homologs regulate activity of genes involved in antibiotic resistance, stress responses, virulence or catabolism of aromatic compounds. They constitute a diverse group of transcriptional regulators that includes both repressors and activators, and the conventional mode of regulation entails a genetic locus in which the MarR homolog and a gene under its regulation are encoded divergently; binding of the MarR homolog to the intergenic region typically represses transcription of both genes, while binding of a specific ligand to the transcription factor results in attenuated DNA binding and hence activated gene expression. For many homologs, the natural ligand is unknown. Crystal structures reveal a common architecture with a characteristic winged helix domain for DNA binding, and recent structural information of homologs solved both in the absence and presence of their respective ligands, as well as biochemical data, is finally converging to illuminate the mechanisms by which ligand-binding causes attenuated DNA binding. As MarR homologs regulate pathways that are critical to bacterial physiology, including virulence, a molecular understanding of mechanisms by which ligands affect a regulation of gene activity is essential. Specifying the position of ligand-binding pockets further has the potential to aid in identifying the ligands for MarR homologs for which the ligand remains unknown. © The Author (2010)
Multiclass deep active learning for detecting red blood cell subtypes in brightfield microscopy.
No full textThe recent success of deep learning approaches relies partly on large amounts of well annotated training data. For natural images object annotation is easy and cheap. For biomedical images however, annotation crucially depends on the availability of a trained expert whose time is typically expensive and scarce. To ensure efficient annotation, only the most relevant objects should be presented to the expert. Currently, no approach exists that allows to select those for a multiclass detection problem. Here, we present an active learning framework that identifies the most relevant samples from a large set of not annotated data for further expert annotation. Applied to brightfield images of red blood cells with seven subtypes, we train a faster R-CNN for single cell identification and classification, calculate a novel confidence score using dropout variational inference and select relevant images for annotation based on (i) the confidence of the single cell detection and (ii) the rareness of the classes contained in the image. We show that our approach leads to a drastic increase of prediction accuracy with already few annotated images. Our original approach improves classification of red blood cell subtypes and speeds up the annotation. This important step in diagnosing blood diseases will profit from our framework as well as many other clinical challenges that suffer from the lack of annotated training data
DinoBloom Model Farm
No full text<p>Model Farm of DinoBloom, a foundation model for generalizable cell embeddings. Github: https://github.com/marrlab/DinoBloom </p>
DeStripe: A Self2Self Spatio-Spectral Graph Neural Network with Unfolded Hessian for Stripe Artifact Removal in Light-Sheet Microscopy
No full textInfusing First Nations Politics in an Academic English Course at UBC Vantage College
No full textNot peer reviewe
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