452 research outputs found
Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization
No full textCarpenter syndrome is an autosomal-recessive multiple-congenital-malformation disorder characterized by multisuture craniosynostosis and polysyndactyly of the hands and feet; many other clinical features occur, and the most frequent include obesity, umbilical hernia, cryptorchidism, and congenital heart disease. Mutations of RAB23, encoding a small GTPase that regulates vesicular transport, are present in the majority of cases. Here, we describe a disorder caused by mutations in multiple epidermal-growth-factor-like-domains 8 (MEGF8), which exhibits substantial clinical overlap with Carpenter syndrome but is frequently associated with abnormal left-right patterning. We describe five affected individuals with similar dysmorphic facies, and three of them had either complete situs inversus, dextrocardia, or transposition of the great arteries; similar cardiac abnormalities were previously identified in a mouse mutant for the orthologous Megf8. The mutant alleles comprise one nonsense, three missense, and two splice-site mutations; we demonstrate in zebrafish that, in contrast to the wild-type protein, the proteins containing all three missense alterations provide only weak rescue of an early gastrulation phenotype induced by Megf8 knockdown. We conclude that mutations in MEGF8 cause a Carpenter syndrome subtype frequently associated with defective left-right patterning, probably through perturbation of signaling by hedgehog and nodal family members. We did not observe any subject with biallelic loss-of function mutations, suggesting that some residual MEGF8 function might be necessary for survival and might influence the phenotypes observed
Integrated optical circuits for quantum information processing
No full textIntegrated optical waveguide circuits are becoming increasingly important in quantum information processing. They provide a platform that is scaleable to multiple qubits, offers stability over the timescales required for multiple photon coincidence based measurements, and by utilizing telecommunications sources and hardware, allows low-loss and efficient operation. This work will present recent results and indicate research directions that are leading towards the demonstration of the required range of functions on chip, particularly on chip, sources, system tomography, phase control operations and detection
At the cross-roads of effective quantum information processing with integrated optical gates
No full textThe use of a silica integrated optical platform developed for the telecoms industry is allowing demonstrations of quantum operations with single photons and Bragg gratings that are challenging notions of classical computing. Operations such as Boson Sampling, number resolving photon detection at 1550nm, quantum teleportation and non-classical interferometry will be reported
The Phil Rogers Russell, D.O. Collection
No full textFinding aid for The Phil Rogers Russell, D.O. CollectionPhil Rogers Russell, D.O., practiced osteopathic medicine in the state of Texas from his 1917 graduation from the American School of Osteopathy, Kirksville, Missouri, until his death at the age of 80 in 1975. He was a strong supporter of the profession and was instrumental in the establishment and growth of the Fort Worth Osteopathic Hospital and the Texas College of Osteopathic Medicine. He won numerous awards and honors from the American Osteopathic Association, the Texas Osteopathic Association, other osteopathic institutions and associations, and civil awards. He was the author of "Quack Doctor", a memoir of his years as an osteopathic physician.The Phil R. Russell, D.O. Collection consists of speeches, articles, book manuscripts, books, memorabilia, photographs, certificates and awards that Dr. Russell authored or was presented during his lifetime
Distributed secondary gas injection via a fractal injector: A nature-inspired approach to improving conversion in fluidized bed reactors
No full textThe conversion in bubbling fluidized bed reactors is suppressed because the interphase mass transfer and gas-solid contact in bubbling fluidized bed reactors are often poor. Most of the gas is present in the form of bubbles, which have low surface-to-volume ratios and are nearly devoid of catalyst particles. The chaotic behaviour of the bubbles is difficult to predict and can change with reactor size, making scale-up very difficult. The work in this thesis presents a novel approach to overcoming these difficulties in bubbling fluidized beds. Nature uses branching, fractal structures, which greatly facilitate mass transfer in natural systems, such as trees and lungs. These structures scale easily, which is a very important feature as the organism grows. This approach can also be applied to fluidized beds. A fractal injector was developed for both quasi 2-D and 3-D beds to distribute a portion of the total gas flow throughout the fluidized bed. To determine the effect of this distributed secondary gas injection on the properties of a gas-solid fluidized bed, the study is split into four topics: the effect on the hydrodynamics of the fluidized bed, the mechanisms leading to the observed changes in the hydrodynamics, the residence time and macroscopic mixing of the gas, and the influence on the performance of the reactor. The results indicate that secondary gas injection via a fractal injector effectively reduces the bubble diameter by up to 30% (~70% reduction in the volume) and increases the gas-solid contact. It is shown that these effects lead to a higher conversion and selectivity in a bubbling fluidized bed reactor. Mechanisms for these effects are proposed.Applied Science
Trends in Osteopathic Authorship in Orthopedic Publications and Its Impact on Adult Reconstruction Match Rates
No full textBackground: Doctors of osteopathy (D.O.) have historically been underrepresented in the orthopedic literature. As adult reconstruction (AR) continues to rank among the most competitive orthopedic fellowships, participation in research likely serves a key role for successfully matching. This study sought to identify trends in D.O. orthopedic publications and assess for correlations between these trends and osteopathic AR match results. Methods: The top 10 orthopedic surgery journals based on impact factor were selected for analysis. Articles published between 2010 and 2021 were screened to assess for publications with a D.O. author, as well as authorship position. A total of 29,499 articles were available for final analysis. Data from the San Francisco Residency and Fellowship Match Services were also reviewed to evaluate the number of osteopathic applicants and their match rates during the same study period. Trends in D.O. publications and osteopathic AR match rates were then assessed for any correlations. Results: From 2010 to 2021, there was a significant increase in orthopedic and arthroplasty-related publications with a D.O. author (P < .0001), as well as D.O. first (P = .0006) and senior authorship positions (P = .009). Osteopathic match rate significantly increased during the study period (P = .003). There was a strong correlation between the increase in osteopathic match rate and arthroplasty-related publications with a D.O. author (r = 0.76). Conclusions: From 2010 to 2021, there was an upward trend of osteopathic orthopedic publications. This increase is strongly correlated with an increase in osteopathic AR match rate. Our findings suggest that authorship in publications may play a key role in successfully matching into an AR fellowship
Protein kinase C activation is necessary but not sufficient for induction of long-term potentiation at the synapse of mossy fiber-CA3 in the rat hippocampus
No full textCorrection to: A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions
No full textThe published online version contains mistake in Acknowledgment Section. The author name "Steve Gorin, M.D." should have been "Steven Gorin, D.O, M.S.Ed."
Protopolybia isthmensis Richards 1978, stat. nov.
No full textProtopolybia isthmensis Richards, 1978 stat. nov. (Figs 7, 8) Pseudochartergus chartergoides isthmensis, Richards 1978: 155, 157. Holotype: ♀, Panama: Sabanas, 20.iv.1923 (R.C. Shan- non) (USNM), not examined; paratype: ♀ Panama: Tocumen, 26.iv.1961 (N.H.L. Krauss); ♀ Costa Rica, Palmar, 11.v.1950 (D.O. Allen) (USNM), not examined (identified from the original description). Protopolybia chartergoides isthmensis: Carpenter et al. 2012: 269, 275. Diagnosis. Length of fore wing 5.56 mm; ventral region of the gena width, about ½ smaller than its width at the midpoint; pronotal carina strong, oblique; prominence in front of the pronotal fovea developed, high, pronotal fovea wide and deep (Fig. 7), metanotal process with apex rounded (Fig. 8). Propodeal valves wide; propodeum deeply excavated above the valve. Color black richly marked with yellow spots; mesoscutum black; pronotum and scutelum almost entirely yellow. Material examined. BOLIVIA: Beni, 1♀, Rurenabaque, 270m, 19.iv.1979 (M. Cooper), 2♀, 25.iv.1979 (M. Cooper) (BMNH); ECUADOR: 1♀, Napo, Limonocha, 280m, 22.vi.1977 (C.W. Ruttenmeyer & R. Chadab) (BMNH); PANAMA: Barro Colorado, 1♀, 13.xi.1923, Bocas del Toro, 1♀, Changuinola, vi.1924 (J.C. Bradley) (AMNH); PERU: 5♀, 2♂, Tingo Maria, 670m, (W. Weyrauch), 1♂, Cuzco, Paucartambo, 600m, 18.iv.1964 (A. Florez) (BMNH). Distribution. * Bolivia: Beni; * Ecuador: Napo, Costa Rica: Palmar; Guatemala: Suchitepéquez; Panama: *Barro Colorado, * Bocas del Toro, Sabanas, Tocumen; Peru.Published as part of Dos Santos Junior, José N. A., Silveira, Orlando T. & Carpenter, James M., 2020, Taxonomic revision of the P. chartergoides species-group of the genus Protopolybia Ducke, 1905 (Hymenoptera: Vespidae, Polistinae), pp. 542-554 in Zootaxa 4858 (4) on pages 547-548, DOI: 10.11646/zootaxa.4858.4.4, http://zenodo.org/record/453752
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