1,721,035 research outputs found
Invecchiamento cutaneo e tumori nell'anziano
No full textTra i segni del processo di involuzione dell’essere umano, quelli legati all’invecchiamento cutaneo sono tra i più visibili. La cute è esposta costantemente a molteplici fattori in grado di accelerarne il naturale processo di invecchiamento; è possibile riconoscere due tipi di invecchiamento:
un invecchiamento intrinseco (di natura principalmente cronologica e genetica), il quale interessa fondamentalmente le regioni che di solito non sono esposte al sole; un invecchiamento estrinseco, in rapporto con i fattori ambientali, soprattutto con l’esposizione ai raggi solari; tale invecchiamento predomina quindi a livello delle zone scoperte (“zone foto-esposte”) e interessa in particolare i soggetti con capelli e occhi chiari (fototipo basso). Questo tipo d’invecchiamento cutaneo può essere favorito da numerosi fattori, oltre che dalla foto-esposizione: fattori comportamentali (abitudini alimentari, tabacco, alcol, droghe); fattori catabolici (patologie croniche); fattori endocrini
Real‐life case‐series experience with tralokinumab in patients with severe atopic dermatitis
No full textNovel variant c.7795-1G>A of COL7A1 gene in a 12-month-old female child with recessive dystrophic epidermolysis bullosa treated with dupilumab
Full text linkImpact of itching, burning and pain in children with psoriasis: An observational monocentric study
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SARS-CoV-2 asymptomatic infection in a patient under treatment with dupilumab
Full text linkWe have read with great interest the letter of the European Task Force on Atopic Dermatitis (ETFAD) on SARS-CoV-2-infection and atopic dermatitis published in JEADV (March 2020)1 in which the authors state: "Targeted treatment selectively interfering with type-2 inflammation such as dupilumab is not considered to increase the risk for viral infections and might thus be preferred ...in a situation such as COVID-19 pandemic".1
Clinical features and therapeutic approaches of genital lichen sclerosus in children: results of an observational monocentric study
Full text linkAbstract Background Lichen sclerosus is a chronic, progressive, inflammatory skin disease that presents unique challenges, particularly in the pediatric population, where limited data exist regarding its manifestation and optimal management. This retrospective observational monocentric study aims to provide insights into the clinical characteristics and therapeutic strategies employed, in a cohort of children and adolescents with genital lichen sclerosus. Methods A comprehensive analysis was conducted involving a cohort of 60 pediatric patients ranging from 1 to 15 years old, all diagnosed with lichen sclerosus. These cases were referred to the Pediatric Dermatology Regional Center of the University of Padua, Italy, between January 2018 and January 2022. Moreover, we propose a treatment protocol that showed beneficial outcomes in all of our patients. Specifically, the initial use of mid-potency topical corticosteroids has proven effective in addressing severe acute flares. Following this acute phase, transitioning to long-term treatment with topical calcineurin inhibitors, such as tacrolimus or pimecrolimus, has demonstrated effectiveness in maintaining remission of the disease and also shown efficacy in treating mild cases. The therapeutic effectiveness was assessed by considering various clinical aspects, including erythema, paleness, skin erosions, and specific symptoms such as itching, burning, and pain. Results Erythema emerged as the predominant clinical sign, reported in 43 (78.3%) patients, followed by paleness, reported in 17 (28.3%) patients. Pruritus was observed in 25 girls (58.1% of females) and 2 boys (11.8% of males), while pain and burning sensations were predominantly reported in female children. Among females, we observed a higher prevalence of cutaneous comorbidities, such as atopic dermatitis, psoriasis, alopecia areata, and linear scleroderma, as opposed to autoimmune systemic diseases, that were more prevalent in males. Regarding therapeutic approaches, 21 (35.0%) patients applied topical corticosteroids, 28 (46,7%) applied topical tacrolimus and 21 (35,0%) applied topical pimecrolimus. All treated patients experienced notable benefits following the initiation of treatment proposed by our protocol. Conclusions This study provides further insights into the clinical presentation and management of lichen sclerosus in the pediatric population, shedding light on potential therapeutic pathways for optimizing patient outcomes in this specific demographic. The proposed protocol appears to be a promising strategy, especially when the onset of the disease occurs during childhood
Vitamins and melanoma
Full text linkA tremendous amount of information was published over the past decades in relation to the role of vitamins in various neoplastic diseases. In particular, several studies showed an inverse relationship between selected vitamins intake and cancer risk. In this review we will focus on the role played by vitamins in melanoma with particular regard to vitamin A, D, K, E and C. Given that vitamin supplementation is easy, convenient, and readily accepted by patients, in the future the use of vitamins in chemoprevention and therapy of melanoma could be encouraged if supported by pre-clinical and clinical evidence
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