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    Evaluation of the effects of ketotifen and clemastine against nasal provocation challenges with allergen

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    In a double-blind, between-patient study, the effectiveness of ketotifen (an anti-anaphylactic and anti-histaminic drug) and clemastine (a pure anti-histaminic drug) in inhibiting nasal symptoms after a nasal provocation test (NPT) was evaluated in 20 seasonal or perennial rhinitics. After a NPT without premedication, ketotifen and clemastine were administered orally at 2 x 1 mg for 3 days. On the 4th day, 2 hours after ingestion of 2 mg of ketotifen or clemastine, the NPT was repeated. The decrease in total nasal score (sneezing, blockage, running and itching) after ketotifen was significantly higher than after clemastine (P < 0.05). The changes in the resistance to airflow in the nasal cavities were not significant in either group
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