50 research outputs found
A Command Governor Approach to Plasma Shape Control
No full textThe paper deals with the application of the socalled Command Governor (CG) approach to the shape control of plasmas in thermonuclear fusion reactors. A primal internal loop controlling the plasma-wall gaps is designed first and a CG device is then tuned to modify, whenever necessary, the reference to the primal loop, taking into account constraints due to voltages saturations on the converters, currents limitations in the active coils, force limits on the mechanical structures, minimum clearance between the plasma and the vacuum chamber wall, maximum induced forces on coils. The reference signal modification is accomplished through an online optimization procedure which embodies plasma model forecasts computed along a finite time virtual receding horizon as usual in model predictive paradigms. The ITER (International Thermonuclear Experimental Reactor) tokamak is assumed as a case study. Numerical simulations are carried out on a numerical nonlinear model taking into account almost a hundred of constraints
Neutrophil gelatinase-associated lipocalin immunoexpression in colorectal carcinoma: A stage-specific prognostic factor?
No full textTNM post-surgical staging is considered to be one of the most powerful prognosticators for colorectal carcinoma. Although patient survival mostly decreases concomitantly to stage increase, in a percentage of cases TNM stage appears only to express the anatomic extent of the neoplasia with no correlation with clinical outcome. Thais, the identification of additional prognostic markers for colorectal cancer is required. Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein that appears to play an important role in colorectal cancer progression. In order to evaluate whether NGAL expression may be considered as a predictor of colorectal cancer progression, we analyzed its correlation with clinicopathological characteristics, as well as with patient progression-free survival in a series of surgically resected colorectal carcinomas. A variable NGAL immunoexpression was found in 24 out of the 64 analyzed cases. When only the positive cases were considered, a significant association was found between a high NGAL expression and the presence of distant metastases or high tumor stage. In addition, the presence of NGAL was a significant negative prognostic marker correlated with a shorter progression-free survival in stage I colorectal carcinoma, but not in the remaining TNM stages. If our findings are confirmed in more extensive analyses on stage I colorectal carcinoma, NGAL assessment may be used in order to select those patients with a higher progression risk and to submit them to adjuvant therapies useful to prevent adverse outcome
Exploiting species-distinctive visual cues towards the automated photo- identification of the Risso's dolphin Grampus griseus
No full textCorticobulbar activity in healthy humans and Parkinson's disease: a study protocol for a novel biomarker of motivational arousal
No full textBackground: The corticobulbar (CB) tract connects the primary motor cortex to oral and facial effectors and may contribute to affective-motivational processes through its interactions with dopaminergic circuits. Prior studies have shown that excitability in the tongue motor cortex (tM1), as well as surface electromyographic (sEMG) activity of submental muscles (SbM), is modulated by hedonic and aversive stimuli. These findings suggest a potential role for the CB system as a physiological interface between motivational states and motor expression. Objectives: This protocol explores whether CB excitability can serve as an indirect marker of motivational arousal in both healthy individuals and patients with Parkinson’s disease (PD), a condition marked by dopaminergic dysfunction. Methods: Study 1 protocol consists in a virtual reality-based shopping task where healthy adults (n = 100) are asked to do different food shipping based on motivational-affective value, while their SbM EMG activity is recorded. Study 2 assesses CB excitability via SbM motor evoked potentials (MEPs) in PD patients (n = 15) before and after a 3-month period of dopaminergic therapy (levodopa), and across ON/OFF medication states. The study design includes a control group (n = 15) tested twice, after a 3-month period, without any drug or placebo administration. Behavioral and self-report measures related to motivation and reward sensitivity are also included in both studies. Conclusion: This protocol combines advanced neurophysiological techniques with innovative experimental paradigms to investigate CB tract cortical excitability linkage with reward-related processing. By integrating neurophysiological, behavioral, and pharmacological measures, this protocol aims to clarify whether CB excitability reflects motivational and dopaminergic states. Findings may contribute to identifying non-invasive biomarkers of motivational functioning in both clinical and normative populations
Correction to: Brivaracetam use in clinical practice: a Delphi consensus on its role as first add‐on therapy in focal epilepsy and beyond
Get PDFThe original article contains an error. In the Consensus Collaborators Group, author name has been inverted during the publication. Family name was captured first instead of the given name. The corrected names as follows: Consensus Collaborators Group: Daniela Audenino, Giovanni Boero, Vittoria Cianci, Mario Coletti Moja, Eduardo Cumbo, Filippo Dainese, Giuseppe Didato, Elisa Fallica, Alfonso Giordano, Emilio Le Piane, Mariangela Panebianco, Marta Piccioli, Pietro Pignatta, Monica Puligheddu, Patrizia Pulitano, Federica Ranzato, Rosaria Renna, Eleonora Rosati, Stella Vergine. The original article has been corrected
Correction to: Brivaracetam use in clinical practice: a Delphi consensus on its role as first add-on therapy in focal epilepsy and beyond (Neurological Sciences, (2024), 10.1007/s10072-024-07485-w)
No full textThe original article contains an error. In the Consensus Collaborators Group, author name has been inverted during the publication. Family name was captured first instead of the given name. The corrected names as follows: Consensus Collaborators Group: Daniela Audenino, Giovanni Boero, Vittoria Cianci, Mario Coletti Moja, Eduardo Cumbo, Filippo Dainese, Giuseppe Didato, Elisa Fallica, Alfonso Giordano, Emilio Le Piane, Mariangela Panebianco, Marta Piccioli, Pietro Pignatta, Monica Puligheddu, Patrizia Pulitano, Federica Ranzato, Rosaria Renna, Eleonora Rosati, Stella Vergine. The original article has been corrected
Genetic risk of prediabetes and diabetes development in chronic myeloid leukemia patients treated with nilotinib
No full textImpaired fasting glucose (IFG) and type 2 diabetes (T2D) represents adverse events in Chronic Myeloid Leukemia (CML) patients treated with the second-generation tyrosine kinase inhibitor (TKI) nilotinib. A genetic risk score (uGRS) for the prediction of insulin resistance, consisting of 10 multiple single-nucleotide polymorphisms (SNPs), has been proposed. We evaluated the uGRS predictivity in 61 CML patients treated with nilotinib. Patients were genotyped for IRS1, GRB14, ARL15, PPARG, PEPD, ANKRD55/MAP3K1, PDGFC, LYPLAL1, RSPO3, and FAM13A1 genes. The uGRS was based on the sum of the risk alleles within the set of selected SNPs. Molecular response (MR)(3.0) and MR(4.0) were achieved in 90% and 79% of the patients, respectively. Before treatment, none of the patients had abnormal blood glucose. During treatment and subsequently follow-up of 80.2 months (range 1-298), 7 patients (11.5%) developed diabetes requiring oral treatment, after a median of 14 months (range 3-98) since nilotinib. Twelve patients (19.7%) developed prediabetes. Prediabetes/diabetes-free survival was significantly higher in patients with an uGRS below 10 compared to higher scores (100% vs 22.8±12.4%, p<0.001). Each increment of 1 unit on the uGRS caused a 42% increase in the prediabetes/diabetes risk (HR=1.42; CI: 1.04-1.94; p=0.026). The presence of more than 10 allelic variants associated to insulin secretion, processing, sensitivity and clearance is predictive of prediabetes/diabetes developing in CML patients treated with nilotinib. In clinical practice uGRS could help tailor the best TKI therapy
. 76 Año 26 (2019) mayo-agosto. Dimensión Antropológica
No full text- Introducción. Mover enfoques, otras perspectivas de lectura de los antiguos textos novohispanos por Clementina Battcock. - Los tlatoque en la Decimatercia relación de Fernando de Alva Ixtlilxóchitl por Yukitaka Inoue Okubo. - El relato cosmogónico del Códice Vaticano A. Una reflexión en torno a la tecnología sacrificial y la dinámica cronológica por Ana Díaz Álvarez. - Los textos cristianos en lengua náhuatl del periodo novohispano: fuentes para la historia cultural por Berenice Alcántara Rojas. - Fuentes de las instancias locales del gobierno novohispano: los cabildos y la jurisdicción de Actopan, siglo XVIII por Annia González Torres. - De neófitos a cristianos. Los indios a través de una fuente eclesiástica: 1527-1728 por Berenise Bravo Rubio. - Biografía y archivos: fray Baltasar de Covarrubias, obispo novohispano del siglo XVII por Patricia Escandón. - Los indios del Museo Nacional de Antropología: una mirada paralela por Haydeé López Hernández. - Beatriz Caiuby Labate y Clancy Cavnar (eds.) Peyote. History, Tradition, Politics, and Conservation por Carlo Bonfiglioli. - José Eduardo Zárate Hernández. La celebración de la infancia. El culto al Niño Jesús en el área purhépecha por Claudia Tomic Hernández Rivera
