1,721,178 research outputs found
The Protein Corona Effect for Targeted Drug Delivery
No full textCurrently, ligand binding to nanoparticle surface is the most widespread strategy for targeting specific tissues by a receptor-mediated mechanism. However, the nanoparticles are immediately covered by a rich protein layerwhen administrated in vivo, the so called “protein corona”, with the immediate consequence that the ligand-receptor recognition may be obscured. It is not the nanoparticle bulk composition or surface functionalization but rather the identity, arrangement and residence time of the proteins of the corona that determine the nanoparticle bio-identity and this is an emerging concept available for use to target specific cell types in a controlled manner.An in-depthunderstanding of the relationship between surface properties of nanoparticles and composition of the ‘protein corona’ is afundamental step towards the design of nanoparticles that, once in the blood, become covered byspecific proteins able to deliver them at the right site of action and promote efficient cell internalization. This “protein corona effect” is a formidable challenge that could lead to a complete renewal of the current strategies of targeted drug delivery
Liposome–protein corona in a physiological environment: Challenges and opportunities for targeted delivery of nanomedicines
No full textActive targeting that exploits the (over)expression of surface receptors in target cells by ligand incorporation is a central concept in nanomedicine research. Despite unprecedented efforts, no targeted liposome-based therapeutics is commercially available for clinical practice. What is inhibiting the efficient translation of targeted liposome technology from bench to bedside? After introduction in the bloodstream, the lipid surface is immediately modified by the adsorption of a “protein corona” and preserving the surface functionality appears to be challenging. On the other hand, a long-standing corona with receptor-binding sites could associate with the target cell long enough to activate the cell's uptake machinery, triggering liposome endocytosis and intracellular cargo delivery. This opens the intriguing possibility to manipulate the corona composition by liposome design. This review will focus on the emerging field of liposome–protein corona research from basic, descriptive research to readily applicable knowledge and technologies for implementation in drug improvement and development
Structural Stability Against Disintegration by Anionic Lipids Rationalizes the Efficiency of Cationic Liposome/DNA Complexes
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