1,721,063 research outputs found
Use of AMH in the Differential Diagnosis of Anovulatory Disorders Including PCOS
Full text linkSince the historical use of gonadotrophin and estradiol levels to define the different anovulatory disorders has shown some limitations, the use of other markers such as anti-müllerian hormone (AMH) has been proposed. This review addresses the role of AMH in the differential diagnosis of anovulatory disorders, especially focusing on its value in the prognostic characterization of their severity. Current limitations and future clinical applications are discussed
Use of progestins to inhibit spontaneous ovulation during ovarian stimulation: the beginning of a new era?
Full text linkAdvances in oocyte and embryo cryopreservation for assisted reproduction prompted new approaches to ovarian stimulation. Attention has been paid to progesterone and its derivatives to block the LH surge, as oocyte vitrification removes possible harmful effects of progestins on endometrial receptivity. This review summarizes the current status of progestin use to inhibit ovulation during ovarian stimulation compared with conventional ovarian stimulation. Progestin-primed ovarian stimulation is shown to effectively inhibit spontaneous ovulation, without affecting the number of retrieved oocytes and embryo quality. Reproductive outcomes from ovarian stimulation with progestins appear similar to those from conventional ovarian stimulation, although large trials are needed to confirm this. Use of progestins allows better control of LH concentrations, lower costs and easier (oral) administration. Therefore, progestin-primed ovarian stimulation could be the first choice for ovarian stimulation in fertility preservation, oocyte donation and preimplantation genetic testing cycles. So-called ‘non-conventional’ ovarian stimulation protocols (luteal and random-start, double ovarian stimulation), which always require oocyte or embryo cryopreservation, may also use progestins to inhibit the endogenous LH surge. Since the ‘freeze-all’ strategy with delayed transfer is mandatory, high responders undergoing IVF could benefit more from this approach. Economic advantage remains to be demonstrated, as do pregnancy and neonatal outcomes
Fatigue of ICU Survivors, No Longer to Be Neglected
No full textIn the last decades, the world of critical care is becoming increasingly focused not only on survival rates, but also on the well-being of critical care survivors. ARDS continues to represent an important public health problem despite an improvement in survival of approximately 60%.1-3 The long-lasting impairment after ARDS has been suggested as a more meaningful outcome measure than mortality.4 Accordingly, the research has focused on the postcritical sequelae that include physical, psychological, and emotional aspects. Patients who survive ARDS are at risk for physical dysfunction, neurocognitive disorders, and worsened quality of life 6 to 12 months after discharge from the ICU
Polycystic ovary syndrome, amenorrhea and the diagnostic role of anti-Müllerian hormone
No full textThe differential diagnosis of anovulatory disorders is actually based on serum gonadotrophin and estradiol levels. However, several other markers have been proposed. The purpose of this review was to underline the role of anti-Müllerian hormone (AMH) as a possible marker in differential diagnosis of the anovulatory diseases and its use as a predictive marker of prognosis. In this article we discuss clinical and experimental evidences actually existing in literature and we suggest new potential clinical application of AMH
A Thorough Study of LoRaWAN Performance under Different Parameter Settings
No full textLoRaWAN is an emerging low-power wide-area network (LPWAN) technology, which is gaining momentum thanks to its flexibility and ease of deployment. Conversely to other LPWAN solutions, LoRaWAN indeed permits the configuration of several network parameters that affect different network performance indexes, such as energy efficiency, fairness, and capacity, in principle making it possible to adapt the network behavior to the specific requirements of the application scenario. Unfortunately, the complex and sometimes elusive interactions among the different network components make it rather difficult to predict the actual effect of a certain parameters setting, so that flexibility can turn into a stumbling block if not deeply understood. In this article, we shed light on such complex interactions for a single-gateway (GW) system by analyzing the effect of some built-in features and configurations, including the GW's limitations in terms of duty cycle and the number of parallel reception paths, the number of allowed retransmissions for confirmed traffic, and the preconfigured data rate used in downlink transmissions. The simulation-based analysis reveals various tradeoffs and highlights some inefficiencies in the design of the LoRaWAN standard. Furthermore, we show how significant performance gains can be obtained by wisely setting the system parameters, possibly in combination with some novel network management policies (e.g., enabling selective prioritization of downlink transmissions at the GW)
Analysis of aerodynamic loads on Formula 3 after field data acquisition and Virtual simulation
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