1,721,484 research outputs found
Rascacielos a la italiana. Construcción de gran altura en los años cincuenta y sesenta
Full text linkIn the fifties and sixties, while Italian engineering was receiving important international awards, the theme of the tall building attracted the attention of the best architects. They made it a field of design experimentation, immediately sensing how the strategic use of the structure could revolutionize the already stereotyped image of the all-steel and glass towers proposed by the International Style. Gio Ponti, Luigi Moretti and the BBPR thus created formidable partnerships with Pier Luigi Nervi and Arturo Danusso, the most active engineers in the field of skyscraper design. The result was at least three masterpieces, among the works created in those years: the Velasca tower and the Pirelli skyscraper in Milan and the Stock Exchange tower in Montreal, which, at the time of its completion, also marked the record for the highest reinforced concrete building in the world.En los años cincuenta y sesenta del siglo XX, mientras la ingeniería italiana recibía importantes premios internacionales, el diseño de los edificios en altura atraía la atención de los mejores arquitectos. Estos entendieron inmediatamente lo mucho que el empleo estratégico de la estructura habría podido revolucionar la ya de por sí estereotipada imagen de la torre de acero y vidrio propuesta por el Estilo Internacional, y lo convirtieron en un campo de experimentación. De esta forma Gio Ponti, Luigi Moretti y la BBPR desarrollaron extraordinarias colaboraciones con Pier Luigi Nervi y Arturo Danusso, los ingenieros más activos en el campo del diseño de rascacielos. De entre los proyectos realizados en esos años, este proceso de colaboración dió como resultado a al menos tres obras maestras: la torre Velasca, el rascacielos Pirelli y la torre de la Bolsa de Valores de Montreal. Esta última, en el momento de su finalización, además significó el récord del edificio de hormigón armado más alto del mundo
L’eleganza del cemento per il design architettonico
No full textL'articolo analizza la storia della costruzione della nuova sede di CiErre ufficio, progettata da Flavio Caronni & Donato Bonamoni Architetti Associat
Surveillance for individuals at high‐risk of pancreatic cancer: Are we finally heading toward evidence?
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RE: ETIOLOGY OF PANCREATIC CANCER, WITH A HYPOTHESIS CONCERNIG THE ROLE OF N-NITROSO COMPOUNDS AND EXCESS GASTRIC ACIDITY.
No full textDiagnostic work-up of digestive endocrine tumors [Work-up diagnostico nei tumori endocrini digestivi]
No full textDiagnostic approach to digestive endocrine tumors mainly depends on the site of the primary tumor. Endoscopy, together with endoscopic ultrasonography, plays a crucial role for diagnosis and treatment of both gastric and colorectal tumors. For pancreatic tumors, multislices helical CT, somatostatin receptor scintigraphy, together with MRI, bone scintigraphy and endoscopic ultrasound are usually required. Promising findings are emerging from the use of video-capsule endoscopy and position emission tomography to detect small bowel tumors. Histological evaluation of tumor tissue is crucial for the management of these tumors
Clinical relevance of the expression of somatostatin receptors in digestive endocrine tumours
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Statin use and survival in resectable pancreatic cancer: confounders and mechanisms.
Full text linkA first point regards the possible activity of drugs other than statins, such as aspirin or metformin, against pancreatic cancer. As many patients use a combination of these drugs, one might speculate that the association between simvastatin and overall survival in resected pancreatic cancer patients might also be explained by the concomitant use of aspirin or metformin, or that these drugs might result synergistic, as hypothesized for colorectal cancer (3). We wonder whether the authors had access to data on aspirin or metformin use for their population.
A second point regards the very high 45% rate of simvastatin or lovastatin users reported by the authors. This figure is different from that of many European countries, thus possibly limiting the attributable fraction of cases for whom the observed findings can be replicated.A first point regards the possible activity of drugs other than statins, such as aspirin or metformin, against pancreatic cancer. As many patients use a combination of these drugs, one might speculate that the association between simvastatin and overall survival in resected pancreatic cancer patients might also be explained by the concomitant use of aspirin or metformin, or that these drugs might result synergistic, as hypothesized for colorectal cancer (3). We wonder whether the authors had access to data on aspirin or metformin use for their population.
A second point regards the very high 45% rate of simvastatin or lovastatin users reported by the authors. This figure is different from that of many European countries, thus possibly limiting the attributable fraction of cases for whom the observed findings can be replicated
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