1,721,161 research outputs found
Systemic and intestinal chronic inflammation, diet and cancer: an unbreakable bond
No full textIdiopathic intestinal inflammatory diseases (IID) include two types of chronic intestinal disorders: Crohn’s disease and ulcerative rectocolitis. Evidence suggests that the IID is derived from the loss of immune tolerance in normal enteric bacteria diners in a genetically susceptible host. In humans, the initial intestinal immune response to intestinal microbiota is closely regulated; this regulation determines if there is a condition of immune tolerance or an inflammatory defensive response. The alteration of the balance of this immune response can lead to IID. In healthy people, the intestinal lamina contains a complex population of cells of the immune system that secrete cytokines with the function of modulating the immune response, both in anti-inflammatory direction that reduce immune response [transforming growth factor β (TGF-β) and interleukin-10] and pro-inflammatory direction. All these mediators are produced by innate and adaptive immune cells, which limit the excessive entry of intestinal microbiota and defend themselves from pathogens. The balance of the immune response is maintained between regulatory T cells and effector T cells (Th1, Th2 and Th17). In IID, innate cells increase the production of tumor necrosis factor alpha (TNF-α), interleukin-1β, interleukin-6, interleukin-12, interleukin-23 and chemokines. There is a marked increase in the thickness of the lamina propria, with an increase in the number of CD4+ T cells, in particular proinflammatory subgroups of T cells, which also produce cytokines and chemokines in high quantities. This increase in the production of cytokines determines the recruitment of further leukocytes, thus determining a vicious circle that maintains the state of inflammatio
Whole-Grain Intake in the Mediterranean Diet and a Low Protein to Carbohydrates Ratio Can Help to Reduce Mortality from Cardiovascular Disease, Slow Down the Progression of Aging, and to Improve Lifespan: A Review
No full textIncrease in the aging population is a phenomenon all over the world. Maintaining good functional ability, good mental health, and cognitive function in the absence of severe disease and physical disability define successful aging. A healthy lifestyle in middle age predisposes successful aging. Longevity is the result of a multifactorial phenomenon, which involves feeding. Diets that emphasize fruit and vegetables, whole grains rather than refined grains, low-fat dairy, lean meats, fish, legumes, and nuts are inversely associated with mortality or to a lower risk of becoming frail among elderly subjects. A regular physical activity and a regular intake of whole grain derivatives together with the optimization of the protein/carbohydrate ratio in the diet, where the ratio is significantly less than 1 such as in the Mediterranean diet and the Okinawan diet, reduces the risk of developing aging-related diseases and increases healthy life expectancy. The purpose of our review was to analyze cohort and case-control studies that investigated the effects of cereals in the diet, especially whole grains and derivatives as well as the effects of a diet with a low protein–carbohydrate ratio on the progression of aging, mortality, and lifespan
Cap. XII Scioglimento e liquidazione delle società di capitali
No full textUno contributo scientificamente rigoroso con un ampio richiamo alle necessità della pratica
Cap.IX Gli organi di controllo delle Società per Azioni ed il controllo dell' Autorità giudiziaria .
No full textIl tema viene affrontato con rigore scientifico collocando la normativa specifica in una prospettiva sistematica
Cap. XI La società in accomandita per azioni
No full textUno contributo scientificamente rigoroso con un attento richiamo alle necessità della pratica
Cap. VII Liquidazione coatta amministrativa
No full textUno contributo attento al rigore sistematico con un ampio richiamo alle necessità operative, per offrire uno strumento didattico efficace e scientificamente corretto
Cardiovascular factors and cognitive impairment: a role for unsaturated fatty acids and Mediterranean diet?
No full text
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