1,721,226 research outputs found
Questions of fault liability. a case study analysis of in-orbit collisions with debris
No full textIn 1972, the international community established a regime of liability for damages occurring in outer space based on 'fault'. Fifty years later, the congested and polluted reality of the space environment has limited dramatically its effectiveness. Only in very few instances, filing a claim under such regime can reasonably ensure compensation to an injured satellite operator. The present paper describes different study cases where resorting to a fault-based liability claim appears problematic. Based on real conjunction assessment alerts, the authors look into various hypothetical scenarios from the perspective of a fictitious satellite operator, whose spacecraft was damaged by an accidental collision in orbit. The aim is to analyse the effective observability over orbital collisions involving small satellites and space debris (attributable or not) and to evaluate the real chances of obtaining compensation, from the operational and legal points of view. At the centre of this study, therefore, is the evaluation, in fact and in law, of the solidity of a potential claim against the perpetrator of the harm. To that end, the discourse takes into consideration the legal difficulties that are generally connected to fault-based liabilities in international law.The definitional vagueness of the term 'fault', the necessity to identify a fault-standard, the proof of failure in the performance of a duty of care, are all elements to consider for filing a claim under the liability regime of 1972.However, next to them, the space environment poses additional hurdles with regard to facts and evi-dence. Satellite operators do not always have the technological instruments to retrieve all the information related to orbital events, such as collisions. Moreover, a complete observability over in-orbit events can be hard to reach for several classes of spacecraft (e.g. small, nano-or pico-satellites). This is especially troublesome for establishing one of the essential elements of 'fault': the so-called "chain of causation". The authors will present their views on how the uncertainties posed by the liability regime of 1972 can be dealt with from a legal and from a technical perspective. In addition, several possible legal solutions and recommendations for the upcoming years of in-orbit operations and space traffic management will be proposed at the end
In vitro modulating effect of zinc chloride and human lipoproteins on phagocytic activity in the elderly.
No full textMODIFICATION OF CARDIOVASCULAR RISK-FACTORS DURING ANTIHYPERTENSIVE TREATMENT - A MULTICENTER TRIAL WITH QUINAPRIL
No full textA large multicentre study involving 6003 [3044 males, 2959 females; mean (+/- SD) age 59 +/- 11 years] mild-to-severe hypertensive patients was carried out to evaluate the effects of the angiotension converting enzyme inhibitor quinapril on blood pressure and on metabolic cardiovascular risk factors during 3 - 6 months' treatment (mean follow-up 90.4 days). The study population included 551 elderly [mean (+/- SD) age 71.9 +/- 9.3 years] patients, 1314 subjects with diabetes mellitus and 154 non-diabetic patients with hyperlipaemia; 4% of patients were lost to follow-up. Diastolic blood pressure decreased from 102 to 87 mmHg (intent-to-treat analysis) and 62% of patients were normalized (diastolic blood pressure below 90 mmHg) at the last evaluable visit. Overall, serum lipids were favourably affected during quinapril treatment; when corrected for changes in body weight, a significant improvement in total, low- and high-density lipoprotein cholesterol, and triglycerides was detected. Quinapril treatment in elderly patients was efficacious and well tolerated, and quinapril appears to be an effective antihypertensive drug devoid of untoward effects on metabolic risk factors for cardiovascular diseas
Questions of Fault Liability: A Case Study Analysis of In-Orbit Collisions With Debris
No full textIn 1972, the international community established a regime of liability for damages occurring in outer space based on 'fault'. Fifty years later, the congested and polluted reality of the space environment has limited dramatically its effectiveness. Only in very few instances, filing a claim under such regime can reasonably ensure compensation to an injured satellite operator. The present paper describes different study cases where resorting to a fault-based liability claim appears problematic. Based on real conjunction assessment alerts, the authors look into various hypothetical scenarios from the perspective of a fictitious satellite operator, whose spacecraft was damaged by an accidental collision in orbit. The aim is to analyse the effective observability over orbital collisions involving small satellites and space debris (attributable or not) and to evaluate the real chances of obtaining compensation, from the operational and legal points of view.At the centre of this study, therefore, is the evaluation, in fact and in law, of the solidity of a potential claim against the perpetrator of the harm. To that end, the discourse takes into consideration the legal difficulties that are generally connected to fault-based liabilities in international law. The definitional vagueness of the term 'fault', the necessity to identify a fault-standard, the proof of failure in the performance of a duty of care, are all elements to consider for filing a claim under the liability regime of 1972. However, next to them, the space environment poses additional hurdles with regard to facts and evidence. Satellite operators do not always have the technological instruments to retrieve all the information related to orbital events, such as collisions. Moreover, a complete observability over in-orbit events can be hard to reach for several classes of spacecraft (e.g. small, nano- or pico-satellites). This is especially troublesome for establishing one of the essential elements of 'fault': the so-called “chain of causation”. The authors will present their views on how the uncertainties posed by the liability regime of 1972 can be dealt with from a legal and from a technical perspective. In addition, several possible legal solutions and recommendations for the upcoming years of in-orbit operations and space traffic management will be proposed at the end
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