103,931 research outputs found
Tutela e Re-Invenzione
No full textIntroduzione A. Capuano, Progetti: Y. Tsiomis, F. Cellini, G. Durbiano, Discussant: G. Azzena, D. Manacorda, Interventi di: M. Angle, L. Caravaggi, A. Criconia, M. Marcelli, A. Mucci, R. Panella, C. Rossetti, A. Ross
Paesaggi Italiani
No full textConvegno organizzato dal Dipartimento di Caratteri degli Edifici e dell'Ambiente, Università di Roma "La Sapienza" e da FH Nordostniedersachsen FB Architektur-Buxtehude (Germania), a cura di R. Cherubini e B. Kauhsen. Interventi di J. Aparicio Guisado, L. Barbera, V. Bordini, U. Cao, A. Capuano, C. Cecchini. A. De Cesaris, M. Del Vecchio, S. Dierna, A. Finkelday, P. Guerrera, G. Marrucci, M. Pazzaglini, A. Terranova, G. Wec
"How Many Roads" n. 158 di Rassegna e Urbanistica
No full textCome recita l'editoriale di Maria Argenti "Rassegna si volge indietro a vedere la strada stavolta, quella percorsa e quella che abbiamo davanti, attraverso le orme del cammino, dei tanti cammini, che andiamo tracciando. Per dire una cosa soprattutto: che essi segnano la qualità della nostra vita urbana; che il tempo percorso a piedi nei tragitti cittadini è un tempo guadagnato alla bellezza di una relazione". Il numero raccoglie riflessioni e progetti sullo spazio della strada nella città contemporanea con scritti di: I. Aquilé, M. Argenti, C. Bianchetti, G. Canto Moniz, A. Capuano, G. Celestini, I. Cortesi, F. Di Carlo, B. Di Donato, A. Ferlenga, I. Ferreira, Gaeta & Springall, S. Rueda Palanzuela, F. Tonucci, A. Valeriani, P. Viganò, E. Roca, M. Sansica, F. Toppetti, C. Zucca
Gaspare Traversi ritrattista dello storico capuano Francesco Granata
No full textIl contributo presenta un nuovo Ritratto di Gaspare Traversi, il cui soggetto viene identificato nello storico e vescovo capuano Francesco Granata
HIGH-TEMPERATURE OXIDATION OF ALUMINUM ELECTROPLATED FE-MN ALLOYS
No full textAustenitic Mn-Al alloys (20-32 W/O Mn, 7-10 Al, 2-3 Si, 1C) were found to have satisfactory oxidation resistance up to 950°C under isothermal conditions in air. Surface enrichment of aluminum is a necessary condition for obtaining an almost pure alumina scale for uses at higher temperatures. Four different Mn-steels were Al-coated by the Capuano electroplating process. In all the steels there was an increase in the hot-oxidation resistance. The best results were obtained with steels containing both Al and Si, and this for temperatures up to 1100°C. No spalling was noticed during rapid cooling of the test pieces. Silicon was found to act as a diffusion barrier to outward iron diffusion. It appears that there is formation of a pure, thin film of alumina from the matrix which interacts with the aluminum diffusing from the superimposed, coating for the formation of good bonds. © 1990 Plenum Publishing Corporation
Hyperelliptic Continued Fractions and Generalized Jacobians:
No full textThese are notes from the minicourse given by Umberto Zannier (Scuola
Normale Superiore di Pisa). The notes were worked out by Laura Capuano,
Peter Jossen,1 Christina Karolus, and Francesco Veneziano. Most of the material
of these lectures, except for the numerical examples which were added by us, is
already available in [42]. The authors wish to thank Umberto Zannier for the
lively discussions in Alpbach, and Olaf Merkert for providing computations of
the examples 3.17, 3.28, 3.29, 3.33, and 3.2
One-step synthesis of poly(lactic-co-glycolic acid)-g-poly-1-vinylpyrrolidin-2-one copolymers
No full textIn this work we present a one-pot synthetic process leading to poly(lactide-co-glycolide)-g-poly(1-vinyl-2-pyrrolidone) (PLGA-g-PVP) copolymers consisting of high molecular weight PLGA carrying oligomeric PVP side chains. PLGA is a lipophilic biodegradable polymer, whereas PVP is hydrophilic, biocompatible and bioeliminable for molecular mass < 40,000. Both polymers have been approved for human use by the US Food and Drug Administration, therefore PLGA-g-PVP copolymers are eligible for medical applications. The water-soluble PVP portion imparts amphiphilic properties to the otherwise hydrophobic PLGA, thus modifying its behaviour in aqueous systems. The title copolymers were prepared by bulk radical polymerization of 1-vinyl-2-pyrrolidone in the presence of PLGA 50:50 acting as polymeric chain transfer agent, and characterized by 1H-NMR, FT-IR, DSC, TGA.They were also saponified giving PLGA degradation products and PVP with molecular mass in the range 2.7K-28K, lower than the renal filtration threshold. The MALDI-TOF spectra of the PVP obtained after PLGA-g-PVP saponification were consistent with low molecular weight PVP chains bearing at one end a hydrogen atom and at the other end monomeric, dimeric or, to a minor extent, trimeric residues of lactic- and glycolic acid or their combinations. These data unambiguously confirmed that the PVP chains had been covalently grafted onto the PLGA backbone. The orthogonal solvent pair ethyl-acetate/methanol was used to fractionate PLGA-g-PVP. Preliminarily, the effectiveness of this pair was tested on PLGA/PVP intimate blends obtained by co-precipitation of PLGA/PVP co-solutions. In this case, the complete separation of the two components was achieved. However, in the case of PLGA-g-PVP only PLGA- and PVP-rich fractions with widely different compositions, but not pure homopolymers could be separated. All un-fractionated PLGA-g-PVP samples and their fractions gave stable nanodispersions in water by the solvent evaporation technique, irrespective of the PVP content. Similar results were obtained with PLGA/PLGA-g-PVP blends, but not with PLGA/PVP blends, which gave unstable nanodispersions in water. These data suggest that the PLGA-g-PVP copolymers have a potential as components of bioeliminable and nanodispersed drug delivery systems
PLGA-g-PVP amphiphilic bioactive and biocompatible copolymers for the fabrication of nanostructured materials
No full textThe aim of this work is to present a one-pot synthetic process leading to poly(lactide-co-glycolide)-g-poly(vinylpyrrolidone) (PLGA-g-PVP) copolymers consisting of high molecular weight PLGA carrying oligomeric PVP side chains. The title copolymers were prepared by chain transfer radical polymerization of N-vinylpyrrolidone in the presence of 50:50 PLGA, acting as polymeric chain transfer agent in the absence of solvents. All copolymers were characterized by 1H-NMR (400 MHz), FT-IR, SEC, MALDI-TOF, DSC, TGA and DLS techniques. PLGA is a lipophilic biodegradable polymer, whereas PVP is hydrophilic, biocompatible and also bioeliminable for molecular weights < 40.000. Both polymers have been approved for human use by the U.S. Food and Drug Administration, therefore the PLGA-g-PVP copolymers are eligible for medical applications. The water-soluble PVP portion imparts amphiphilicity to the otherwise hydrophobic PLGA, thus modifying its behavior in aqueous systems. In particular, PLGA-g-PVP samples spontaneously form nanoparticles when dispersed in water. These nanoparticles, besides dissolving hydrophobic drugs, for instance antimalarial drugs, in the inner core, are expected to show higher compatibility than native PLGA towards many drugs known to interact with PVP. In addition, PLGA-g-PVP samples, when used as additives, dramatically improved wettability of hydrophobic materials, as for instance polyesters, processed as nanofibers and intended for applications involving contact with the body fluid
NMR and computational data of two novel antimicrobial peptides
No full textAbstractHere we report details on the design and conformational analysis of two novel peptides showing antimicrobial properties, as reported in the research article, “New antimicrobial peptides against foodborne pathogens: from in silico design to experimental evidence” G. Palmieri, M. Balestrieri, Y.T.R. Proroga, L. Falcigno, A. Facchiano, A. Riccio, F. Capuano, R. Marrone, G. Campanile, A. Anastasio (2016) [1]. NMR data, such as chemical shifts in two different solvents as well as aCH protons deviations from random coil values and NOE patterns, are shown together with the statistics of structural calculations. Strategy and particulars of molecular design are presented
One-step synthesis of poly(lactic-co-glycolic acid)-g-poly-1-vinylpyrrolidin-2-one copolymers
No full textThe radical polymerization of 1-vinylpyrrolidin-2-one (NVP) in poly(lactic-co-glycolic acid) (PLGA) 50: 50 at 100 degrees C leads to amphiphilic PLGA-g-PVP copolymers. Their composition is determined by FT-IR spectroscopy. Thermogravimetric analyses agree with FT-IR determinations. Saponification of the PLGA-g-PVP polyester portion allows isolating the PVP side chains and measuring their molecular weight, from which the average chain transfer constant (C-T) of the PLGA units is estimated. The MALDI-TOF spectra of PVP reveal the presence at one chain end of residues of either glycolic acid-or lactic acid- or lactic/glycolic acid dimers, trimers and one tetramer, the other terminal being hydrogen. This unequivocally demonstrates that grafting occurred. Accordingly, the orthogonal solvent pair ethyl acetate-methanol, while separating the components of PLGA/PVP intimate mixtures, fails to separate pure PVP or PLGA from the reaction products. All PLGA-g-PVP and PLGA/PLGA-g-PVP blends, but not PLGA/PVP blends, give long-time stable dispersions in water
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