1,721,025 research outputs found
Morir en soledad: la terrible situación de las personas que fallecen por COVID-19 y el dolor de sus familiares en un contexto de desborde del sistema de salud
Full text linkLa Organización Mundial de la Salud declaró la pandemia de covid-19 el 11 de marzo de 2020. El coronavirus pandémico afecta a todo el mundo desde que se identificó en diciembre de 2019 en Wuhan, China. La pandemia causó un fuerte impacto psicosocial en todo el planeta (1), además de los ya conocidos efectos negativos sobre la economía. Se ha discutido y trabajado en estrategias de cuarentena, aislamiento, políticas de atención médica, protocolos para la aplicación inmediata de tratamientos con medicamentos ya aprobados y ensayos clínicos acelerados, entre otros puntos relevantes. Sin embargo, nos debemos un debate. A medida que la enfermedad progresa a través de una comunidad, el sufrimiento se agrava debido a procedimientos estrictos que a menudo pierden de vista la humanidad y que, a mi entender, deben ser revisados.Instituto de VirologíaFil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina.Fil: Capozzo, Alejandra Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Dying alone due to COVID-19 : do the needs of the many outweigh the rights of the few—or the one?
Full text linkThe COVID-19 pandemic, caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been striking the world since it was first identified in December 2019 in China. The World Health Organization (WHO) declared the outbreak a “public health emergency of international concern” on January 30th, 2020, and recognized its pandemic status on March 11th. The pandemic has caused universal psychosocial impact (1) and global economic disruption. Discourse and measures have been discussed focused on lockdown strategies, healthcare policies (2), application of emerging treatments, accelerated clinical trials, among others. Management guidelines are continuously updated based on emerging findings (3). However, as the disease spreads through a community, suffering deepens due to strict procedures that, arguably, may be questioned from an ethical standpoint. The pandemic has sufficiently disrupted and impaired people’s livelihood worldwide, and every effort to prevent any additional suffering must be made.Instituto de VirologíaFil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capozzo, Alejandra Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Editorial : Women in veterinary epidemiology and economics
Full text linkWhile the number of women graduating from veterinary schools has increased globally over the last few decades, this has not translated into reduced gender bias and inequity in academia and veterinary science research (1). Gender-based discrimination starts at university where women veterinary students are pushed toward “women-majority fields” (e.g., small animal medicine) (2) or where they face discrimination during animal husbandry placements (3). Following graduation, there is clear evidence that gender differences persist in pay and attainment of senior and leadership positions (4). Women's advancement and standing in academic veterinary medicine may in part be influenced by pronounced gender differences in the authorship of veterinary research articles. Women are less likely to be a senior author on a research paper and they are significantly underrepresented in some fields such as surgical and production animal research (5). Gender disparity in professional leadership roles like editorial boards—the median publisher in veterinary sciences had 27.5% editorships belonging to women (6)—can summate by impairing peer recognition and academic advancement.Instituto de VirologíaFil: Capozzo, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vial, Flavie. Animal and Plant Health Agency; Reino Unid
Morir en soledad: la terrible situación de las personas que mueren por COVID-19 y el dolor de sus familiares en un contexto de desborde del sistema de salud
Full text linkCarta al Editor.Fil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Gastronómicas. Instituto de Virología E Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentin
Application of serological tests to assess the efficacy of foot-and-mouth disease vaccination in dairy cattle with or without viral leucosis
Full text linkEnzootic bovine leucosis is an infectious viral disease of cattle distributed worldwide that affect dairy cattle over 2 years of age. This disease produces changes in the animal´s immune system that may affect vaccine efficacy. During the last 10 years many reports have highlighted the association of BLV infection with a diminished or modified immune response against routinely used cattle vaccines. Our group has focused on studying the possible role of BLV infection on the immune response elicited by foot-and-mouth disease primo or multiple vaccinations making use of serological assays aimed to characterize the antibody response in terms of IgG-subtypes and avidity. These tools demonstrated to be very useful for analyzing the effects of BLV in FMD vaccine immunity. The use of simple high-throughput assays delving on the quality of the antibody response is paramount for assessing vaccine efficacy and can help in analyzing the impact of BLV infection at herd level.Instituto de VirologíaFil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Apicomplexan profilins in vaccine development applied to bovine neosporosis
Full text linkNeospora caninum, an intracellular protozoan parasite from the phylum Apicomplexa, is the etiologic agent of neosporosis, a disease considered as a major cause of reproductive loss in cattle and neuromuscular disease in dogs. Bovine neosporosis has a great economic impact in both meat and dairy industries, related to abortion, premature culling and reduced milk yields. Although many efforts have been made to restrain bovine neosporosis, there are still no efficacious control methods. Many vaccine-development studies focused in the apicomplexan proteins involved in the adhesion and invasion of the host cell. Among these proteins, profilins have recently emerged as potential vaccine antigens or even adjuvant candidates for several diseases caused by apicomplexan parasites. Profilins bind Toll-like receptors 11 and 12 initiating MyD88 signaling, that triggers IL-12 and IFN-γ production, which may promote protection against infection. Here we summarized the state-of-the-art of novel vaccine development based on apicomplexan profilins applied as antigens or adjuvants, and delved into recent advances on N. caninum vaccines using profilin in the mouse model and in cattle.Fil: Mansilla, Florencia Celeste. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Editorial : Foot-and-mouth disease epidemiology, vaccines and vaccination : moving forward
Full text linkVaccination has played a major role in foot-and-mouth disease (FMD) control. There are different approaches to the design and implementation of vaccination campaigns, and epidemiological information is paramount in influencing the vaccine and vaccination strategy that best suit each geographic location. FMD-endemic regions typically organize vaccination campaigns as a routine preventive control policy or to mitigate the impact of the disease. The majority of currently used vaccines are formulated with chemically inactivated whole-viral particles and suitable adjuvants such as single and double oil emulsions. The most recent strains circulating in a particular region are typically selected as antigens based on the results of vaccine-matching data and in vitro experiments, however, predictions based on vaccine-matching approaches are usually uncertain without a live virus challenge in natural hosts combined with reliable field data. Vaccine selection and successful vaccination campaigns rely on a deep knowledge of the epidemiology of the region where these vaccines will be used, as well as access to the appropriate diagnostic tools to underpin these campaigns.Instituto de VirologíaFil: Capozzo, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vosloo, Wilna. Commonwealth Scientific and Industrial Research Organisation (CSIRO) Health and Biosecurity. Transboundary Disease Mitigation. Australian Centre for Disease Preparedness; AustraliaFil: de los Santos, Teresa. United States Department of Agriculture. Agricultural Research Service. Plum Island Animal Disease Center; Estados UnidosFil: Pérez, Andrés M. University of Minnesota. Department of Veterinary Population Medicine; Estados UnidosFil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Perez Filgueira, Daniel Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Accuracy of traditional and novel serology tests for predicting cross-protection in foot-and-mouth disease vaccinated cattle
No full textFoot-and-mouth disease virus (FMDV) antigenic-match between vaccine and field viruses has traditionally been estimated in vitro by computing the r1 value using virus neutralization test (VNT) or ELISA titers. In this study we compared the accuracy in predicting cross-protection between the r1 value estimated by VNT and two recently developed tests that measure IgG subtypes and avidity. Data analyzed consisted of 64 serum samples from FMDV A24/Cruzeiro vaccinated bovines challenged with the heterologous A/Argentina/2001 strain and evaluated for podal generalization. We computed the tests sensitivity (Se), specificity (Sp), and receiving operating characteristics (ROC) curve. The heterologous IgG1/IgG2 ratio was the most accurate test (Se = 0.71, Sp = 0.98), followed by heterologous IgG1 (Se = 0.53, Sp = 0.96), VNT (Se = 0.47, Sp = 1.00), whereas r1 accuracy was substantially low (Se = 0.41, Sp = 0.81). Because sensitivity of individual tests was limited, we argue that two or more of the tests should be used in combination to produce accurate estimates of protection.Instituto de VirologíaFil: Brito, Bárbara Patricia. University of California-Davis. Center for Animal Diseases Modeling and Surveillance; Estados UnidosFil: Perez, Andrés Maximiliano. University of California-Davis. Center for Animal Diseases Modeling and Surveillance; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Short communication: Bovine leukemia virus infection in adult cows does not interfere with foot-and-mouth disease vaccination
Full text linkBovine leukemia virus (BLV) is a widespread infection that can affect innate and adaptive immunity; however, little information exists on how BLV infection affects foot-and-mouth disease virus (FMDV) vaccination programs. Vaccination for FMDV is compulsory in many regions of the world, and vaccine efficacy is monitored by measuring total antibodies against this virus. In a previous study, we observed that BLV-infected heifers produced a lower amount of antibodies in response to FMDV at first vaccination. In this follow-up study, we show that BLV status does not interfere with the total level and avidity of anti-FMDV–specific antibodies induced after repetitive routine vaccination in adult cattle. This is relevant information for the proficiency of vaccine-based FMDV control programs in BLV-endemic regions.Fil: Jaworski, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sala, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capozzo, Alejandra Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
An IgG1 single-dilution avidity ELISA predicts cross-protection against heterologous foot-and-mouth disease virus challenge after vaccination
No full textThis study aims to analyze if the results from different serological assays, used alone or combined, could match the outcome of challenge infection with foot-and-mouth disease virus (FMDV) after vaccination in cattle. Day-of-challenge sera from animals that had been vaccinated 21 days before with monovalent formulations containing inactivated A Iran 96 or A Iran 99 virus strains were used. Challenge and serology were performed with A22 Iraq strain. IgG1 titers and total-IgG avidity indexes were significantly higher in protected animals (p 0.05). An IgG1 avidity ELISA was developed to analyze in one step, IgG1 levels and avidity. This assay estimated protection with 96 % accuracy. A strong agreement with challenge results was achieved (K = 0.85), suggesting a role of high-affinity IgG1 in protection against FMDV. These results support the assessment of the single dilution IgG1-Avidity ELISA to predict cross-protection in FMDV-vaccinated cattle.Fil: Cardoso, Nancy Patricia. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Eschbaumer, Michael. Federal Research Institute for Animal Health; AlemaniaFil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentin
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