1,036 research outputs found
DANTE, ARNO, PISA (I SALVATI E I SOMMERSI)
No full textQuesto saggio considera tutti i riferimenti all'Arno nella "Commedia" di Dante, rapportandoli anche ai diversi momenti della biografia del poeta.. Si considerano anche i nomi propri Pisa e Pisano e i personaggi pisani (o legati con Pisa) che Dante incontra o menziona nel suo viaggio oltremondano. Mentre in Paradiso non ve ne sono, tutte le personalità e i nomi propri pisani presenti nell’Inferno e nel Purgatorio sono collegati alle lotte politiche e militari svoltesi tra il 1285 e il 1293. Il conte Ugolino, l’arcivescovo Ruggeri, capitano e podestà di Pisa dopo l’arresto di Ugolino, e Guido da Montefeltro, cui furono poi conferiti a Pisa pieni poteri, sono tutti all’inferno. Nino Visconti, che fu pure capitano e podestà di Pisa accanto a Ugolino e fu cacciato dalla città il giorno prima dell’arresto del conte, è invece salvato in Purgatorio, ove Dante colloca pure Gano Scornigiani (Purg Vi 17-18), alleato e parente del Visconti. Dante combatté accanto a Nino nel 1289 (presa di Caprona da parte della Lega Guelfa: Inf. XXi 95);, più in generale, Nino fu una figura molto importante per il giovane Dante. Rispetto alla famosa invettiva contro Pisa. si nota che, capraia e Gorgona possono essere viste dai Monti Pisani, che costituivano la più importante base per Nino e i fuoriusciti pisani, e in particolare dalla fortezza di Verruca, che si erge sopra Caprona
RNA polymerase i transcription is modulated by spatial learning in different brain regions
No full textLong-term memory is accompanied by changes in neuronal morphology and connectivity. These alterations are thought to depend upon new gene expression and protein synthesis over a distributed network of brain structures. Although, much evidence supports the idea that the creation of stable, persistent memory traces requires synthesis of new proteins, the role of rRNA transcription and nucleolar activity in learning and memory has hardly been explored. rRNAs needed for protein synthesis result from the activity of two different RNA polymerases, RNA polymerase I and RNA polymerase III, transcribing for 47S RNA and 5S RNA respectively. In this study we first investigated the effects of spatial training in the Morris water maze on 47S RNA transcription in the central nervous system, demonstrating bi-directional modulation of its expression over a distributed neural network. We found learning induced increases in the nucleolar organizer regions in the hippocampus. Finally we demonstrated that intra-hippocampal administrations of CX-5461 (0.6μg/side), the specific RNA Polymerase I inhibitor, impair the ability of mice to locate the platform in the same task. These results suggest that de novo rRNA transcription is a necessary step for spatial memory consolidation and that after learning it occurs in several brain regions with a complex spatio-temporal dynamic
Large-signal device simulation in time- and frequency-domain: a comparison
Full text linkThe aim of this paper is to compare the most common time- and frequency-domain numerical techniques for the determination of the steady-state solution in the physics-based simulation of a semiconductor device driven by a time-periodic generator. The shooting and harmonic balance (HB) techniques are applied to the solution of the discretized drift-diffusion device model coupled to the external circuit embedding the semiconductor device, thus providing a fully nonlinear mixed mode simulation. The comparison highlights the strong and weak points of the two approaches, basically showing that the time-domain solution is more robust with respect to the initial condition, while the HB solution provides a more rapid convergence once the initial datum is close enough to the solution itsel
Learning Dependent Epigenetic Modifications In The Ventral Striatum Are Necessary For Long-Term Memory Storage
No full textLearning induced epigenetic modifications in the ventral striatum are necessary for long-term memory
No full textEpigenetic modifications such as histone acetylation in cortical or allocortical regions have been shown to be necessary for the formation of long-term memories. Here we investigated whether similar changes were occurring also in the ventral striatum and whether they are necessary for the consolidation of aversive memory. To this purpose we performed immediate post-training focal administrations of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA, 5, 10 or 15 mu g/side) or the DNA methyltransferase (DNMT) inhibitor, 5-aza-2 '-deoxycytidine (5-AZA, 0.0625 or 0.125 mu g/side) in the ventral striatum of mice trained in one-trial inhibitory avoidance task. Intra-ventral striatal SAHA administrations, immediately after training, improved memory retention. Opposite effects were found with 5-AZA. We also found that training in the one-trial inhibitory avoidance is accompanied by increased acetylation of specific residues that can be further increased by intra-VS SAHA administrations. Intra-VS 5-AZA administrations on the other hand reduced training-induced histones acetylation at the same residues. These findings imply the occurrence of histone acetylation in the ventral striatum in order to store aversive memory. Moreover, they suggest that the effects induced by the DNMT inhibitor 5-AZA may at least partially due to blockade of H3 and H4 acetylation. These results suggest that the contemporary activation of similar molecular mechanisms might be needed in different brain regions to enable the formation of long-term memories. (C) 2014 Elsevier B.V. All rights reserved.Epigenetic modifications such as histone acetylation in cortical or allocortical regions have been shown to be necessary for the formation of long-term memories. Here we investigated whether similar changes were occurring also in the ventral striatum and whether they are necessary for the consolidation of aversive memory. To this purpose we performed immediate post-training focal administrations of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA, 5, 10 or 15 μg/side) or the DNA methyltransferase (DNMT) inhibitor, 5-aza-2′-deoxycytidine (5-AZA, 0.0625 or 0.125 μg/side) in the ventral striatum of mice trained in one-trial inhibitory avoidance task. Intra-ventral striatal SAHA administrations, immediately after training, improved memory retention. Opposite effects were found with 5-AZA. We also found that training in the one-trial inhibitory avoidance is accompanied by increased acetylation of specific residues that can be further increased by intra-VS SAHA admini
A note on the author citation and typification of Cineraria aurantiaca Hoppe (Tephroseris integrifolia subsp. aurantiaca; Asteraceae)
No full textBartolucci, Fabrizio, Villani, Mariacristina, Galasso, Gabriele (2021): A note on the author citation and typification of Cineraria aurantiaca Hoppe (Tephroseris integrifolia subsp. aurantiaca; Asteraceae). Phytotaxa 512 (4): 297-299, DOI: 10.11646/phytotaxa.512.4.6, URL: http://dx.doi.org/10.11646/phytotaxa.512.4.
Preictal dysfunctions of inhibitory interneurons paradoxically lead to low-voltage-fast onset seizures in Dravet syndrome
No full textOriginal data for: Preictal dysfunctions of inhibitory interneurons paradoxically lead to their rebound hyperactivity and to low-voltage-fast onset seizures in Dravet syndrome
No full text<p>Original Data for the article:</p>
<p>Capitano F., Kuchenbuch M., Lavigne J, Chaptoukaev H., Zuluaga M., Lorenzi M., Nabbout R. and Mantegazza M. (<strong>2024</strong>) Preictal dysfunctions of inhibitory interneurons paradoxically lead to their rebound hyperactivity and to low-voltage-fast onset seizures in Dravet syndrome. <em>Proceedings of the National Academy of Sciences USA</em><em>. </em>10.1073/pnas.2316364121</p>
<p>Dataforfigures.zip are the original data presented in the figures.</p>
<p>DataSeizurePrediction.zip are the original data used for seizure prediction; it contains:</p>
<ol>
<li>A csv file containing the error rates and detection rates as a function of time, for 5 repetitions.</li>
<li>A "freq" folder containing 2 .npy files: the series resulting of the feature extraction (windowed spectral signal composition) for the baseline set (inter_freq.npy) and the test set (pre_freq.npy) as python dictionnaries.</li>
<li>A "cusum" folder containing 2 .npy files: the cusum series for the baseline set (inter_cusum.npy) and the test set (pre_cusum.npy) as dictionnaries.</li>
</ol>
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Riscrivere La buona novella di Fabrizio De André in siciliano:
Full text linkDuring 2021 the indipendent label Musica del Sud released the sicilian adaptation of Fabrizio De André's La buona Novella, which was first published in 1970. The article therefore presents an interview with Francesco Giunta, author of the project and the translation, and makes use of the valuable conversation with Ignazio Macchiarella, in order to explore the depth of the work in its musical, literary and linguistic nuances.
Nel 2021 l'etichetta indipendente Musica del Sud ha pubblicato il riadattamento in siciliano de La buona Novella di Fabrizio De André, uscito per la prima volta nel 1970.
L'articolo presenta dunque l'intervista a Francesco Giunta, l'autore del progetto e della traduzione, e si avvale del prezioso dialogo con Ignazio Macchiarella, condotto allo scopo di indagare la profondità dell'opera nelle sue sfaccettature musicali, letterarie e linguistiche. 
A new study on the Newell-Whitehead-Segel equation with Caputo-Fabrizio fractional derivative
No full textIn this research, we propose a new numerical method that combines with the Caputo-Fabrizio Elzaki transform and the q-homotopy analysis transform method. This work aims to analyze the Caputo-Fabrizio fractional Newell-Whitehead-Segel (NWS) equation utilizing the Caputo-Fabrizio q-Elzaki homotopy analysis transform method. The Newell-Whitehead-Segel equation is a partial differential equation employed for modeling the dynamics of reaction-diffusion systems, specifically in the realm of pattern generation in biological and chemical systems. A convergence analysis of the proposed method was performed. Two-dimensional and three-dimensional graphs of the solutions have been drawn with the Maple software. It is seen that the resulting proposed method is more powerful and effective than the Aboodh transform homotopy perturbation method and conformable Laplace decomposition method in the results. © 2024 the Author(s), licensee AIMS Press
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