1,721,331 research outputs found
EUS-FNA cytology of pancreatic exocrine tumors. Comparison of experiences with pathological diagnosis]
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Prognostic and predictive response therapy factors in cancer disease (colorectal, breast, liver, lung, gastric, renal and prostate cancers)
No full textExploring prognostic and predictive response therapy factors in cancer disease is one of the most exciting issues of modern oncological science. Targeting intracellular signalling molecules is one of the novel approaches in which basic and translational researches meet clinical practice to define the best management of malignancies. The goal for target therapies is to identify agents that target tumor-specific molecules, thus sparing normal tissues. Those molecules are called biomarkers, and their identification is recommended for correct therapeutic planning. Hence, the contribution of clinical and surgical pathology to define cancer prognostic groups and treatment responsive tumors is essential not only for the efficacy of the cures, but also for ethical, economical, and social reasons. The promises of tailored (personalized) therapy are now almost certainly realistic and can give concrete hope to many cancer patients in the world. In this book, we have tried to describe the "state of art" in these fields of oncology, specifically considering prognostic and predictive response therapy factors in colorectal, breast, lung, gastric, renal, liver and prostate cancers
Atypical melanocytic lesions: a historical overview
Full text linkThe distinction between atypical Spitz lesions, conventional melanocytic nevi including Spitz nevi, and malignant melanomas may be difficult in some cases or may even be impossible. The histological assessment of these lesions is necessary to ensure correct diagnosis and treatment. Nevertheless, pathologists may be subject to suboptimal concordance in the diagnosis of some atypical lesions. In literature, certain atypical lesions have been defined differently: the terms atypical and metastasising Spitz tumour, malignant Spitz nevus, borderline and intermediate melanocytic tumour, melanocytic tumour of uncertain malignant potential MELTUMP, and low-grade malignant melanoma have been introduced to designate this heterogeneous group of pathological entities and variants. This review focuses on some issues concerning the historical background, diagnostic state-of-the-art, evolution, and classification of these complicated lesions
Case report: Axillary hibernoma - Radiological and pathological findings of a rare tumour
No full textClinical and biological applications of image analysis in non-Hodgkin's lymphomas
No full textThe technical procedures and the main applications of image analysis in non-Hodgkin's lymphoma pathology have been described by reviewing the pertinent literature. With the advent of sophisticated computer-based technology, the possibility of objectively evaluating cell morphology, in situ marker expression, DNA indexes, and complex structural features may become a relevant part of the pathologist's expertise. (C) 1998 John Wiley & Sons, Ltd
Differential diagnosis of malignant gastric tumors. A pathological appraisal with reference to locally advanced gastric carcinoma
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[Anatomopathological findings correlated with high-dose recombinant interleukin-2. Review of the literature and description of 2 autopsy cases]
No full textCalcified gastric cancer - CT findings before and after chemotherapy - Case report and discussion of the pathogenesis of this type of calcification
No full textDiffuse calcifications in primary gastric cancer are very rare, most of them being found in mucinous adenocarcinoma. We present the CT aspects of a locally advanced gastric cancer, which showed partial response to neo-adjuvant chemotherapy. The pathological features of the surgical specimen after total gastrectomy are also reported and the pathogenesis of the calcifications is discussed. (C) Elsevier Science Inc., 1997
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