5,154 research outputs found
Statin treatment as a confounding factor in human trials with vitamin E
No full textInterventional trials with vitamin E have been planned on the assumption that it could reduce atherosclerotic progression via inhibition of oxidative stress. These trials have been conducted in patients at risk for or with cardiovascular disease, but the results have been divergent. The reason for the equivocal results is still unclear. We have recently demonstrated that in patients with hypercholesterolemia, the administration of a statin is associated with reduced urinary isoprostanes, a marker of oxidative stress, and normalization of circulating levels of vitamin E, indicating that statins enhance the antioxidant status. Based on these arguments, we reanalyzed the interventional trials with vitamin E to see if concomitant use of statins could have created a potential bias. We reviewed 9 interventional trials, each including >1000 patients. In 5 of the 9 trials, the concomitant use of statins was reported. In the arm randomized to vitamin E, a concomitant use of statins was reported in at least one-third of the population. In some trials, the percentage of patients given statins was >50%, suggesting that a large part of the follow-up population was likely useless treated with vitamin E in view of the concomitant antioxidant effect of statins. Also, the antiatherosclerotic effect of statins could have reduced the possibility that a prespecified sample size had an adequate power to observe a difference between vitamin E and placebo-treated groups. We therefore suggest that a meta-analysis of trials with vitamin E should be redone by excluding patients who concomitantly used statins
Antioxidants and cardiovascular disease
No full textOBJECTIVE Oxidative stress appears to play a key role in the pathogenesis of atherosclerosis. METHOD Agents that prevent the oxidation of low-density lipoprotein have reduced the development and progression of this disease in a range of in vitro experiments and animal models. RESULT In the last decade, many trials of antioxidants in patients with cardiovascular disease have been conducted, but the results have been ambiguous. The reason for the disappointing findings is unclear, but one possible explanation is the lack of identification criteria for patients who are potential candidates for antioxidant treatment. CONCLUSION This review analyzes data reported to date, in order to determine whether these clearly support the premise that patients at risk of cardiovascular disease may be candidates for this therapeutic option
23-05
No full textSupplemental material for Cangemi, F. (2023), Representing intonation contours with periograms, Talk at 346th Meeting of the Phonetic Society of Japan, June 2023
23-09
No full textCangemi, F. (2023). Visualising fluency: English interviews of Japanese students. Proceedings of the 37th General Meeting of the Phonetic Society of Japan. Sapporo, September 2023
23-05
No full textSupplemental material for Cangemi, F. (2023), Representing intonation contours with periograms, Talk at 346th Meeting of the Phonetic Society of Japan, June 2023
PraaPer
No full textCangemi, F. & A. Albert (2023). PraaPer: simple, rich and intuitive representations for intonation and tone. Proceedings of The Second International Conference on Tone and Intonation. Singapore, November 2023
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