1,354,899 research outputs found
Prevention of bacterial and mycotic infections in patients with hematological malignancies
No full textInfections are a major cause of morbidity and mortality among immune-compromised patients. The author discusses bacterial and mycotic infection prophylaxis in granulocytopenic patients with hematologic malignancies. Various strategies have been devised to prevent such infections including: combination oral antibacterial and antifungal prophylaxis with quinolones and newer azoles (fluconazole, itraconazole), high efficiency air filtration, protective isolation, and central venous catheter management. However, the emergence of antibiotic-resistant organisms continues to pose a major challenge to the successful eradication and prevention of infections in neutropenic hosts, and thus demands the development of innovative antibiotic approaches and infection control procedures
The Role of Wilms’ Tumor Gene (WT1) Expression as a Marker of Minimal Residual Disease in Acute Myeloid Leukemia
No full textThe Minimal Residual Disease(MRD) monitoring in acute myeloid leukemia (AML) is crucial to guide treatment after morphologic complete remission, to define the need for consolidation with allogeneic stem cell transplantation (Allo-SCT), and to detect impending relapse allowing early intervention. However, more than 50% of patients with AML lack a specific or measurable molecular marker to monitor MRD. We reviewed the key studies on WT1 overexpression as a marker of MRD in AML patients undergoing an intensive chemotherapy program, including Allo-SCT. In addition, we provided some practical considerations on how to properly use WT1 expression as an MRD marker, considering its strengths and weaknesses. In order to achieve the best sensitivity and specificity, it is recommended to refer to the standardized method of European LeukemiaNet and its defined threshold (250 WT1 copies/10(4) Abelson (ABL) on Bone Marrow-BM and 50 WT1 copies/10(4) ABL on Peripheral Blood-PB), which has been validated in a large and multicenter cohort of patients and normal controls
Wilms' tumor 1 gene expression levels in acute promyelocytic leukemia compared to other acute myeloid leukemia subtypes
No full textAlla ricerca di Alezeia: la ‘Trilogia del Serenismo’ di Luigi Candoni
No full textLuigi Candoni (1921-1974) today: an almost unknown author, despite he witnessed the tran-sition from the author's theatre to the director's theatre in Italy, where he brought the avant-garde of Beckett, Adamov, Ionesco. Defending the role of the theatre author, he proposes as the Italian theatre avant-garde way a theatre of hope, seeking the Being beyond the shoals of Nothingness: here is the Trilogy of Serenism, consisting of an essay of the same name, and The Olympics of the clowns, Oedipus in Hiroshima, Nobody dies
Plasma cell leukemia occuring in a patient with thrombocythemia treated with hyroxyurea and busulphan
No full textPlasma cell leukemia (PCL) is a rare aggressive lymphoproliferative disease with a short median survival and a very poor prognosis. We report the case of a 63-year-old man who developed a PCL after 5 years of chemotherapy with hydroxyurea and busulphan for Essential thrombocythemia (ET). The karyotype showed a deletion of chromosome 7 and the plasma cells cytofluorimetric examination revealed a high expression of Multidrug Resistance related P-glycoprotein (PGP). After the second cycle of VAD chemotherapy the patient had a severe pneumonia and died with refractory PCL. This is a rare example of the coexistence of a chronic myeloproliferative and lymphoproliferative diseases in the same patient, and to the best of our knowledge, the first reported in the literature involving PCL and ET. Moreover, this case shows the possibility of secondary malignancies developing in patients treated with busulphan and hydroxyurea for chronic myeloproliferative disorders. © 2004 Taylor & Francis Ltd
Leukaemic infiltration of the retina at onset of Philadelphia-positive acute lymphoblastic leukaemia revealed by stratus optical coherence tomography
No full textPlasma cell leukemia occurring in a patient with thrombocythemia treated with hydroxyurea and busulphan
No full textExtramedullary progression of multiple myeloma under thalidomide therapy despite concomitant response of medullary disease”
No full textPrevention of bacterial and mycotic infections in patients with hematological malignancies
No full textInfections are a major cause of morbidity and mortality among immunocompromised patients. This report discusses bacterial and mycotic infections prophylaxis in the granulocytopenic patients with hematologic malignances. Various strategies have been derised to prevent the infections: a combination of oral antibacterial and antifungal prophylaxis with quinolones and newer azoles (fluconazole, itraconazole), high efficiency particulate air filtration, protective isolation and management of central venous catheter. However, the emergence of antibiotic resistant organism continues to pose a major challenge to the successful eradication and prevention of infections in neutropenic host, and demands the developement of innovative approaches to antibiotic use and infection control procedures
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