1,355,171 research outputs found
CandA Light Blue Check Shirt
No full textLight blue check man's shirt in original packaging. Label: CANDA Made for C and A. Maker: CandA - from the The Betty Smithers Design Collection at Staffordshire University.
Reflections of an Adult with Cystic Fibrosis on the Personal Significance of Mindfulness as Therapeutic Technique and Way of Life
No full textThis brief presentation describes how the author utilizes mindfulness to promote surviving and thriving and growth through adversity in living with cystic fibrosis. The insights draw on a career of research on resilience as well as personal experience living with CF. It describes benefits of mindfulness as a therapeutic technique and as a way of life. This transcript also provides access to other freely accessible publications and videos that expand on related topics. The original presentation’s reference information: Canda, E. R. (2021, April 15). Moderator and Presenter, Sweating the Small (and Big) Stuff: Emotional Health Through the Life Span. ResearchCon 2021, Cystic Fibrosis Foundation [online]. Presenters: Rachel Cravens, Anna Georgiopoulus, Christopher Siracusa, CJ Bathgate, and Edward Canda. Canda presentation: “Reflections of an Adult with CF on the Personal Significance of Mindfulness as Therapeutic Technique and Way of Life. Video at https://www.youtube.com/watch?v=Ww83FRD0e0c
Specific ubiquitin-dependent protein degradation requires a trimeric CandA complex in Aspergillus nidulans
No full textE3-Cullin-RING-Ubiquitin-Ligase-Komplexe werden durch die kovalente Modifikation ihres Grundgerüst-Proteins Cullin mit dem ubiquitin-ähnlichem Modifizierer Nedd8 aktiviert. Deneddylasen, wie das COP9 Signalosom (CSN) und DenA interagieren und destabilisieren diese Komplexe durch die Trennung der Isopeptidbinding zwischen Nedd8 and Cullin. Nicht-neddylierte Culline können Cand1/A binden, welches der Austauschfaktor für die Substrat-Erkennungsmodule der E3 RING Ligasen ist. Die meisten Eukaryoten besitzen ein einzelnes Cand1 Polypeptit. Veränderungen in der Gen Anordnung führten bei dem Schimmelpilz Aspergillus nidulans und seinen Verwandten zur Trennung des CandA Gens in zwei separate Gene, die für jeweils eine CandA Protein-Untereinheit kodieren. CandA-N entspricht dem N terminalen Cand1 und verdeckt die Neddylierungsstelle. CandA-C entspricht dem C terminalen Cand1 und inhibiert die Bindung der Substratadapter-Proteine. Die Blockierung der Nedd8-Bindestelle und der Substratadapter-Austausch sind in allen Eukaryoten konserviert. Die A. nidulans CandA Proteine werden für die asexuelle Konidiosporenbildung, die sexuelle Fruchtkörperentwicklung, für einen koordinierten Sekundärmetabolismus und für E3 Ligase-Aktivität benötigt. Doppeldeletionsmutanten von candA-N/denA, candA-N/csnE und candA-C/csnE können keine Kleistothecien bilden und zeigen eine reduzierte asexuelle Entwicklung. Eine Dreifachdeletion von candA-N/C/csnE zeigt zusätzlich ein eingeschränktes vegetatives Wachstum. Diese Beobachtungen zeigen, dass die Deneddylierung und der Austausch der Substratadaptoren für die Variablilität von Substraten der E3 Ligasen von großer Bedeutung sind. Das Gen candA-C liegt fünf offene Leserahmen vor dem Gen candA N. Diese Dissertation zeigt, dass das CandA-C orthologe Protein in A. fumigatus eine zusätzliche pilzspezifische N-terminale Verlängerung von 190 Aminosäuren hat, welche in einem separaten Exon kodiert ist, aber im menschlichen Cand1 fehlt. In A. fumigatus entspricht diese Erweiterung dem CandA-C1 protein von A. nidulans. Dieses ist ein drittes CandA Protein von 19 kDa und wird von einem dritten candA Gen kodiert, welches 269 bp vor dem candA-C Gen liegt. Die drei CandA-C1, CandA-C und CandA-N Proteine bilden einen Dreierkomplex der hauptsächlich im Zellkern zu finden ist. Dieser Komplex interagiert spezifisch mit CulA und unterstützt dessen Neddylierung. Der Komplex bindet jedoch keine anderen Culline. CanA von A. fumigatus bindet neben CulA auch CulC E3 Ligasen. Die Aspergillus-spezifische CandA-C1 Untereinheit hat im Vergleich zu den anderen beiden CandA Proteinen gemeinsame und unterschiedliche Funktionen. Diese Arbeit zeigt, dass CandA-C1 von A. nidulans für das vegetative Wachstum, die Reifung der Kleistothecien und der damit verbundenen Ascosporenbildung sowie der Aktivierung der Ubiquitinmarkierungs-Systeme verantwortlich ist. Anders als CandA-N und CandA-C hat CandA C1 keinen Einfluss auf den Sekundärmetabolismus von Orsellinsäure-Derivaten. Der N-terminale Bereich des A. fumigatus CanA ist genauso wichtig für die Sporenkeimung und das vegetative Wachstum wie CandA C1 von A. nidulans. Diese Ergebnisse machen die Aspergillus-spezifische CandA/CanA Untereinheit zu einem interessanten Kandidaten für die Medikamentenforschung gegen Pilzinfektionen bei zum Beispiel immungeschwächten Patrienten mit bronchopneumonaler Aspergillose verursacht durch A. fumigatus, ohne dabei das menschliche Ubiquitin-Proteasome-System zu beeinträchtigen.E3 cullin-RING ubiquitin ligase complexes are activated by modification of their cullin scaffold protein with the ubiquitin-like modifier Nedd8. Deneddylases as the COP9 signalosome (CSN) or Den1/A interact and destabilize these complexes by cleaving the isopeptide bond between Nedd8 and cullin. Non-neddylated cullins can bind Cand1/A, which is the exchange factor for the substrate recognition subunits of the E3 RING ligases. Most eukaryotes possess a single Cand1 polypeptide. The mold Aspergillus nidulans and its relatives encountered a DNA rearrangement, which resulted in separate genes for two CandA polypeptides. CandA-N corresponds to N terminal Cand1, blocking the neddylation site and CandA-C inhibits the interaction to the adaptor and substrate recognition subunits and thereby corresponds to the C-terminal Cand1. The Nedd8 blocking and adaptor-receptor exchange features are conserved in all eukaryotes. A. nidulans CandA proteins are required for asexual conidia production, sexual fruiting body formation, coordinated secondary metabolism and E3 ligase activity. Double deletion strains of candA N/denA, candA-N/csnE and candA-C/csnE resulted in strains without the potential of cleistothecia formation and with reduced asexual development. A triple deletion strain of candA-N/C/csnE was additionally reduced in vegetative growth. These observations underline the importance of deneddylation and the exchange of substrate recognition subunits to allow E3 ligase activity towards a variety of substrates. The gene candA-C is located five open reading frames upstream of candA-N. This thesis shows that the CandA-C ortholog of the human pathogen A. fumigatus includes an additional fungal specific N-terminal 190 amino acid extension encoded by an extra exon, which is not present in human Cand1. This extension of A. fumigatus corresponds to A. nidulans CandA-C1 as a third CandA protein of 19 kDa encoded by a third candA gene 269 bp upstream of candA-C. The three fungal CandA-C1, CandA-C and CandA-N proteins form a trimeric complex mainly in the nucleus. This complex specifically interacts with CulA, supporting its neddylation but does not interact with other cellular cullins. A. fumigatus CanA is different and interacts with CulA as well as CulC E3 ligases. The Aspergillus specific CandA-C1 subunit has common but also distinct cellular functions in comparison to the other CandA proteins. This work shows that CandA-C1 of A. nidulans is required for vegetative growth, cleistothecia maturation including ascospore formation and activation of the ubiquitin labeling machinery. However, unlike the other CandA proteins, CandA-C1 does not affect the secondary metabolism of orcinol derivatives. A. fumigatus CanA N-terminal extension is as important for germination and vegetative growth as CandA-C1 in A. nidulans. These results make the Aspergillus- specific CandA/CanA subunit an interesting candidate for a drug-based approach to control fungal spreading in immunocompromised patients that are infected with e.g. A. fumigatus caused bronchopulmonary aspergillosis without affecting the human ubiquitin-proteasome system
Canda alsia Winston, Vieira & Woollacott 2014
No full textCanda alsia Winston, Vieira & Woollacott, 2014 (Fig. 29) Canda philippinensis: Souza 1989: 497. Canda alsia Winston, Vieira & Woollacott, 2014: 164, figs. 15, 16 (cum syn.); Almeida et al. 2015b: 3. Material examined. UFBA 1192, UFBA 2361–62, Camamu Bay, 13°53’S, 38°59’W, 18–20 m, coll. October 2012 (on sponge Bubaris sp.); UFBA 1663, UFBA 2363–64, Camamu Bay, 13°53’S, 38°59’W, 18–20 m, coll. October 2012 (on sponge Haliclona (Soestella) melana); UFBA 1670, UFBA 2365–67 Camamu Bay, 13°53’S, 38°59’W, 18–20 m, coll. October 2012 (on sponge Tedania ignis). Remarks. Canda alsia has erect rooted colonies with branches connected by transverse tubular kenozooids, autozooids with one inner distal spine and a narrow mushroom-shaped scutum, short curving vibracula and ooecia with single and large fenestra (Fig. 29) (Winston et al. 2014). Despite the other records of Canda from the Brazilian coast— Canda philippinensis Canu & Bassler, 1929; Canda retiformis Pourtalès, 1867 and Canda simplex Busk, 1884 (Vieira et al. 2008) —Winston et al. (2014) suggested they belong to C. alsia (see Winston et al. 2014 for more information). Some specimens of C. alsia from Brazil were found attached on cable (Winston et al. 2014). Caribbean species of Canda are commonly found in coral reefs (e.g., Winston 1984, 1986; Hughes & Jackson 1992). Here we present the first record of a Canda species associated with sponges. Distribution. Atlantic: endemic to Brazil (Bahia, Espírito Santo and Rio de Janeiro) (Winston et al. 2014; present study).Published as part of Almeida, Ana C. S., Souza, Facelucia B. C., Menegola, Carla & Vieira, Leandro M., 2017, Diversity of marine bryozoans inhabiting demosponges in northeastern Brazil, pp. 281-323 in Zootaxa 4290 (2) on page 293, DOI: 10.11646/zootaxa.4290.2.3, http://zenodo.org/record/89271
CandA Dark Blue Check Mans Shirt
No full textMan's dark blue check shirt in original packaging. Button down collar, long sleeves. label: CANDA Made for C and A. Maker: CandA - from the The Betty Smithers Design Collection at Staffordshire University.
Ngodo og Regulo Canda
No full textSome of the best wood for making Timbila notes, grows in the district of this Chief, Regulo Canda. His orchestra, perhaps as a direct result, has been noted for its tone quality. His district includes part of the sea coast and is covered with thick bush with many cashew nut trees. It will be noted that the spelling of the titles of the movements changes with the dialect of the district. In the west it is 'Wemiso' while further east it is 'Mwemiso'. Four movements from the Ngodo xylophone orchestral dance of Regulo Canda with 10 to 19 xylophones and 1 or 2 rattles. (-12.54-)
Ngodo of Regulo Canda
No full textSome of the best wood for making Timbila notes, grows in the district of this Chief, Regulo Canda. His orchestra, perhaps as a direct result, has been noted for its tone quality. His district includes part of the sea coast and is covered with thick bush with many cashew nut trees. It will be noted that the spelling of the titles of the movements changes with the dialect of the district. In the west it is 'Wemiso' while further east it is 'Mwemiso'. Four movements from the Ngodo xylophone orchestral dance of Regulo Canda with 10 to 19 xylophones and 1 or 2 rattles. (-12.54-)
Integration of Fungus-Specific CandA-C1 into a Trimeric CandA Complex Allowed Splitting of the Gene for the Conserved Receptor Exchange Factor of CullinA E3 Ubiquitin Ligases in Aspergilli
No full textAspergillus species are important for biotechnological applications, like the production of citric acid or antibacterial agents. Aspergilli can cause food contamination or invasive aspergillosis to immunocompromised humans or animals. Specific treatment is difficult due to limited drug targets and emerging resistances. The CandA complex regulates, as a receptor exchange factor, the activity and substrate variability of the ubiquitin labeling machinery for 26S proteasome-mediated protein degradation. Only Aspergillus species encode at least two proteins that form a CandA complex. This study shows that Aspergillus species had to integrate a third component into the CandA receptor exchange factor complex that is unique to aspergilli and required for vegetative growth, sexual reproduction, and activation of the ubiquitin labeling machinery. These features have interesting implications for the evolution of protein complexes and could make CandA-C1 an interesting candidate for target-specific drug design to control fungal growth without affecting the human ubiquitin-proteasome system.E3 cullin-RING ubiquitin ligase (CRL) complexes recognize specific substrates and are activated by covalent modification with ubiquitin-like Nedd8. Deneddylation inactivates CRLs and allows Cand1/A to bind and exchange substrate recognition subunits. Human as well as most fungi possess a single gene for the receptor exchange factor Cand1, which is split and rearranged in aspergilli into two genes for separate proteins. Aspergillus nidulans CandA-N blocks the neddylation site, and CandA-C inhibits the interaction to the adaptor/substrate receptor subunits similar to the respective N-terminal and C-terminal parts of single Cand1. The pathogen Aspergillus fumigatus and related species express a CandA-C with a 190-amino-acid N-terminal extension domain encoded by an additional exon. This extension corresponds in most aspergilli, including A. nidulans, to a gene directly upstream of candA-C encoding a 20-kDa protein without human counterpart. This protein was named CandA-C1, because it is also required for the cellular deneddylation/neddylation cycle and can form a trimeric nuclear complex with CandA-C and CandA-N. CandA-C and CandA-N are required for asexual and sexual development and control a distinct secondary metabolism. CandA-C1 and the corresponding domain of A. fumigatus control spore germination, vegetative growth, and the repression of additional secondary metabolites. This suggests that the dissection of the conserved Cand1-encoding gene within the genome of aspergilli was possible because it allowed the integration of a fungus-specific protein required for growth into the CandA complex in two different gene set versions, which might provide an advantage in evolution
FOTOGRAFÍA DE MONUMENTO FUNERARIO A FEDERICO VAZQUEZ Y CANDA, 1910
No full textFotografía del monumento funerario dedicado en el cementerio de San Sebastián a Federico Vazquez y Canda, en 1908, por la Academia General Militar, de la cuál fue su primer director.Reproducción digital. Madrid : Red.es : Ministerio de Defensa, 201
A Transcultural Perspective on Social Work with Cultural and Spiritual Diversity
No full textEdward R. Canda, MA, MSW, Ph.D., is Professor Emeritus and Coordinator of the Spiritual Diversity Initiative in the School of Social Welfare at the University of Kansas (KU). He was on the faculty at KU from 1989 to 2019 and at the University of Iowa for three years prior. Dr. Canda was also a Courtesy Professor of Religious Studies and a Member of the Center for East Asian Studies at KU. Dr. Canda frequently lectures and consults on topics related to spiritual diversity in social work, nationally and internationally.
Dr. Canda’s career work addresses connections between cultural diversity, spirituality, transilience, and philosophy of social welfare in relation to social service, health, mental health, and disabilities. In 2013, Dr. Canda received the Council on Social Work Education’s Significant Lifetime Achievement Award for innovations on spirituality through scholarship and education.A Transcultural Perspective on Social Work with Cultural and Spiritual Diversity offers theoretical and practical guidelines for ways that social workers and other professional helpers can honor the distinctiveness of particular cultures and spiritual views as well as the common qualities of humanity. The transcultural perspective promotes mutual understanding and collaboration toward wellbeing and justice for all people and all beings. This book reveals the historical development and current state of the art of Dr. Edward Canda’s innovations on culturally appropriate and spiritually sensitive social work, with examples from refugee resettlement, interreligious dialogue, cross-cultural marriage, international social work collaborations, and spiritual strengths-based practice. A Transcultural Perspective provides a concise and thorough framework for inclusive spiritually sensitive social work including ethical decision-making, spiritual assessment, therapeutic relationship, mindfulness, fulfillment supporting organizational culture, and global ecological compassion and justice
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