170,399 research outputs found
Mould 2: (Photo) Writing Degree Zero
No full textMould is a platform for transdisciplinary investigation, which aims to interpret the complexity of contemporary culture by stimulating a dialogue between its multiple forms and contaminations. We believe that the mould, embracing the notions of imprint and tracing, conveys our view of cultural press: a place to record the existing, make it circulate, generate new ideas. Mould is a project by Alessio Cancellieri and Jonathan Pierini, published by Mould Press. A. C
Mould 1: Cultures of Assembly
No full textMould is a platform for transdisciplinary investigation, which aims to interpret the complexity of contemporary culture by stimulating a dialogue between its multiple forms and contaminations. We believe that the mould, embracing the notions of imprint and tracing, conveys our view of cultural press: a place to record the existing, make it circulate, generate new ideas. Mould is a project by Alessio Cancellieri and Jonathan Pierini, published by Mould Press. A. C
Applications of biocatalytic C=C bond reductions in the synthesis of flavours and fragrances
No full textIndustrial biotechnology and biocatalysis can provide very effective synthetic tools to increase the sustainability of the production of fine chemicals, especially flavour and fragrance (F&F) ingredients, the market demand of which has been constantly increasing in the last years. One of the most important transformations in F&F chemistry is the reduction of C[dbnd]C bonds, typically carried out with metal-catalysed hydrogenations or hydride-based reagents. Its biocatalytic counterpart is a competitive alternative, showcasing a range of advantages such as excellent chemo-, regio- and stereoselectivity, ease of implementation, mild reaction conditions and modest environmental impact. In the present review, the application of biocatalysed alkene reductions (from microbial fermentations with wild-type strains to engineered isolated ene-reductase enzymes) to synthetic processes useful for the F&F industry will be described, highlighting not only the exquisite stereoselectivity achieved, but also the overall improvement when chirality is not involved. Multi-enzymatic cascades involving C[dbnd]C bioreductions are also examined, which allow much greater chemical complexity to be built in one-pot biocatalytic systems
El rol del guadalupanismo en la guerra de Independencia de México
No full textEl gudalupanismo en Nueva España , a diferencia de lo que sucedió en otras colonias latinoamericanas, tuvo el rol de cohesión y unión nacionales , todavía antes de que México fuera una nación idependiente
Tra memoria dell’antico e identità culturale. Tempi e protagonisti della scoperta dei Monti Lepini
No full textDifferential diagnosis between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) assessed by high-resolution computed tomography (HRCT)
No full textDifferential diagnosis between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) assessed by high-resolution computed tomography (HRCT). Radiologia Medica, vol. 19, n. 5-6, 2005, pp. 472-487 Bna C, Zompatori M, Poletti V, Spaggiari E, Chetta A, Calabro E, Ormitti F, Berti E, Cancellieri A, Chilosi M. Sezione di Scienze Radiologiche, Dipartimento di Scienze Cliniche, Universita degli studi di Parma, Parma, Italy. PURPOSE: The aim of this study was to assess the accuracy of high-resolution CT in the differential diagnosis between UIP and NSIP, and the correlations with histological and functional findings. MATERIALS AND METHODS: Patients underwent thin-collimation spiral CT (1 mm), with 10-mm interval. Pulmonary function was assessed with a pneumotacograph and body plethysmograph connected with a computer for data analysis. Three pathologists, blinded to the clinical and functional data, provided a histological diagnosis based on established criteria reported in the literature. The study group only included patients with a histological diagnosis of either UIP or NSIP. RESULTS: We achieved a correct diagnosis of NSIP in 86.6% of cases (76.4% sensitivity; 84.6% specificity), whereas UIP was correctly diagnosed in 73.3% of cases (84.6% sensitivity; 76.5% specificity). An 80% agreement was achieved between the HRCT and histological findings in the whole case series (73% sensitivity, 87% specificity, p<0.01). CONCLUSIONS: The most important finding of our study was that a ground glass appearance equal to or greater than 15% is highly suggestive of NSIP. Therefore, our results could be useful to confirm a suggested diagnosis of NSIP
BETA-ARRESTIN DEPENDENT REGULATION OF CYTOSKELETON DYNAMICS AND SIGNALLING OF CHEMOKINE RECEPTOR ACKR2
No full textChemokines promote leukocyte migration through the activation of dedicated G-protein coupled receptors. Beyond conventional chemokine receptors, which directly induce cell migration through heterotrimeric Gαi-mediated signalling events, a set of atypical chemokine receptors (ACKRs) have been described. ACKRs do not activate Gαi-mediated signalling activity, but they are mainly involved in shaping the chemokine gradient. The best characterized member of this family is ACKR2.
ACKR2, previously referred to as D6, is a scavenger receptor that binds with high affinity to 13 inflammatory CC chemokines. The scavenging activity of ACKR2 relies on its intracellular traffic properties. Under homeostatic conditions, ACKR2 is mainly localized in intracellular stores associated with both early Rab4/5-positive and recycling Rab11-positive endosomes. At increasing levels of chemokines, ACKR2 increases plasma membrane abundance through an acceleration in the rate of Rab11-depedent recycling pathway, in order to optimize its chemokine scavenging activity. Here, I demonstrated that the intracellular distribution of ACKR2 is maintained by cytoskeletal dynamics. After chemokine engagement, ACKR2 activate a G-protein-independent and β-arrestin-dependent Rac1-PAK1-LIMK1 signalling cascade to finely regulate the actin cytoskeletal and the microtubules network reorganization, to promote receptor up-regulation and scavenging function. ACKR2 is able to recruit and associates both β-arrestins in basal condition, at membrane and intracellular levels, but only β-arrestin1 is recruited after active ligand stimulation, in order to promote a β-arrestin1-dependent signalling pathway, required for supporting the myosin Vb-dependent ACKR2 up-regulation and scavenging properties
Inquadramento fitosociologico delle comunità vegetali nelle aree umide residuali del litorale nord della provincia di Roma
No full textDissecting trafficking and signaling of atypical chemokine receptors
No full textAtypical chemokine receptors are a distinct subset of chemokine receptors able to modulate immune responses by acting as chemokine decoy/scavengers or transporters. Intracellular trafficking properties sustained by Gαi-independent signaling have emerged as a major determinant of their biological properties, which support continuous uptake, transport, and/or concentration, of the ligands. Here, we are providing methods to study both trafficking and signaling of this class of chemokine receptors focusing on the atypical chemokine receptor D6 that degrades inflammatory CC chemokines. © 2013 Elsevier Inc
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