5,978 research outputs found
Apoptosis, ageing and cancer susceptibility
No full textWe have previously shown that peripheral blood lymphocytes (PBL) from individuals carrying a germline TP53 mutation show a dramatically reduced apoptotic response to radiation. As part of a study of this phenomenon, we also investigated apoptotic response in a series of breast cancer patients lacking TP53 mutations and in a control group of individuals without cancer. There was a significant reduction in mean apoptotic response with increasing age in all groups. These findings are consistent with a number of studies in rodents, which have demonstrated a reduction in DNA damage-induced apoptosis with increasing age. In addition, after adjusting for age, breast cancer patients showed significantly reduced apoptotic responses compared with normal controls (P=0.002). The odds ratio for breast cancer in women with an apoptotic response of <35%, compared with women with a response of >49%, was 6.42 (95% CI 1.68-24.6). The data further support the hypothesis that a reduction in apoptotic response to DNA damage with increasing age may play a significant role in the age-related increase in cancer
Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins
No full textApoptosis is a physiological form of cell death important in normal processes such as morphogenesis and the functioning of the immune system. In addition, defects in the apoptotic process play a major role in a number of important areas of disease, such as autoimmune diseases and cancer. DNA-damage-induced apoptosis plays a vital role in the maintenance of genomic stability by the removal of damaged cells. Previous studies of the apoptotic response ( AR) to radiation-induced DNA damage of lymphoid cells from individuals carrying germline TP53 mutations have demonstrated a defective AR compared with normal controls. We have also previously demonstrated that AR is reduced as individuals age. Results from the current study on 108 twins aged 18-80 years confirm these earlier findings that the AR of lymphoid cells to DNA damage is significantly reduced with increasing age. In addition this twin study shows, for the first time, that DNA-damage-induced AR has a strong degree of heritability of 81% ( 95% confidence interval 67-89%). The vital role of DNA-damage-induced apoptosis in maintaining genetic stability, its relationship with age and its strong heritability underline the importance of this area of biology and suggest areas for further stud
A POSSIBLE SCREENING-TEST FOR INHERITED P53-RELATED DEFECTS BASED ON THE APOPTOTIC RESPONSE OF PERIPHERAL-BLOOD LYMPHOCYTES TO DNA-DAMAGE
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Comparison of monoclonal antibody Ki-67 reactivity with grade and DNA flow cytometry of breast carcinomas
No full textastromatt42/digb_sfgs: Release for 10.21203/rs.3.rs-106679/v1
No full textThis release was used to compute the results in https://doi.org/10.21203/rs.3.rs-106679/v1
For any queries please contact the corresponding author
#nowplaying-rs
No full text<p>The nowplaying-rs dataset features context- and content features of listening events. It contains 11.6 million music listening events of 139K users and 346K tracks collected from Twitter. The dataset comes with a rich set of item content features and user context features, as well as timestamps of the listening events. Moreover, some of the user context features imply the cultural origin of the users, and some others - like hashtags - give clues to the emotional state of a user underlying a listening event.</p>
<p>The dataset contains three files:</p>
<ul>
<li>user_track_hashtag_timestamp.csv contains basic information about each listening event. For each listening event, we provide an id, the user_id, track_id, hashtag, created_at </li>
<li>context_content_features.csv: contains all context and content features. For each listening event, we provide the id of the event, user_id, track_id, artist_id, content features regarding the track mentioned in the event (instrumentalness, liveness, speechiness, danceability, valence, loudness, tempo, acousticness, energy, mode, key) and context features regarding the listening event (coordinates (as geoJSON), place (as geoJSON), geo (as geoJSON), tweet_language, created_at, user_lang, time_zone, entities contained in the tweet).</li>
<li>sentiment_values.csv contains sentiment information for hashtags. It contains the hashtag itself and the sentiment values gathered via four different sentiment dictionaries: AFINN, Opinion Lexicon, Sentistrength Lexicon and vader. For each of these dictionaries we list the minimum, maximum, sum and average of all sentiments of the tokens of the hashtag (if available, else we list empty values). However, as most hashtags only consist of a single token, these values are equal in most cases. Please note that the lexica are rather diverse and therefore, are able to resolve very different terms against a score. Hence, the resulting csv is rather sparse. The file contains the following comma-separated values: <hashtag, vader_min, vader_max, vader_sum,vader_avg, afinn_min, afinn_max, afinn_sum, afinn_avg, ol_min, ol_max, ol_sum, ol_avg, ss_min, ss_max, ss_sum, ss_avg >, where we abbreviate all scores gathered over the Opinion Lexicon with the prefix 'ol'. Similarly, 'ss' stands for SentiStrength. </li>
</ul>
<p>Please note that user_track_hashtag_timestamp.csv and context_content_features.csv partly provide the same features. We deliberately chose to do so to be able to provide useable files that do not have to be matched and joined with each other to perform e.g., simple recommendation tasks.</p>
<p>Please also find the training and test-splits for the dataset in this repo. Also, Asmita provides prototypical implementations of a context-aware recommender system based on the dataset at https://github.com/asmitapoddar/nowplaying-RS-Music-Reco-FM.</p>
<p><br>
If you make use of this dataset, please cite the following paper where we describe and experiment with the dataset:</p>
<p>@inproceedings{smc18,<br>
title = {#nowplaying-RS: A New Benchmark Dataset for Building Context-Aware Music Recommender Systems},<br>
author = {Asmita Poddar and Eva Zangerle and Yi-Hsuan Yang},<br>
url = {http://mac.citi.sinica.edu.tw/~yang/pub/poddar18smc.pdf},<br>
year = {2018},<br>
date = {2018-07-04},<br>
booktitle = {Proceedings of the 15th Sound & Music Computing Conference},<br>
address = {Limassol, Cyprus},<br>
note = {code at https://github.com/asmitapoddar/nowplaying-RS-Music-Reco-FM},<br>
tppubtype = {inproceedings}<br>
}</p>
Converter USB/RS 485
No full textThis thesis is describing problematic of realisation of converter from USB type media into the universal RS-485 bus which is mainly used for the industrial applications (author is using frequently as a device in order to enable communication between server and RFID devices). This thesis contains theoretical information, realisation of the device itself and assesment of reached targets
Converter USB/RS 485
No full textThis thesis is describing problematic of realisation of converter from USB type media into the universal RS-485 bus which is mainly used for the industrial applications (author is using frequently as a device in order to enable communication between server and RFID devices). This thesis contains theoretical information, realisation of the device itself and assesment of reached targets
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