1,721,058 research outputs found
Adrenergic receptors in physiopathology and clinical medicine: current role and research prospectives
No full textPreliminary clinical experience of the Istituto Rizzoli with the GMRS modular reconstructive prosthesis for the lower limb
No full textPRELIMINARY CLINICAL EXPERIENCE OF THE ISTITUTO RIZZOLI WITH THE GMRS MODULAR RECONSTRUCTIVE PROSTHESIS FOR THE LOWER LIMB
No full textPRELIMINARY CLINICAL EXPERIENCE OF THE ISTITUTO RIZZOLI WITH THE GMRS MODULAR RECONSTRUCTIVE PROSTHESIS FOR THE LOWER LIM
Mid -term results of an expandable “non invasive” prosthesis in children with distal femur bone sarcomas”
No full textMid -term results of an expandable “non invasive” prosthesis in children with distal femur bone sarcoma
A new modular prosthesis (GMRS-Stryker) used as an hybrid for revision of HMRS prostheses.
No full textPalliative treatments: electrochemotherapy and thermoablation.
No full textMetastatic disease is a major cause of pain and decreased quality of life in patients with cancer. Autopsy studies have shown that up to 85% of patients who die from breast, prostate or lung cancer have histological evidence of bone metastases at the time of death. In Europe, the number of new cases of bone metastases per year is approximately 1 in 100,000. Worsening of patients’ quality of life is due to associated symptoms such as intractable pain, pathological fractures, spinal cord compression, hypercalcemia and reduction of movement and performance status
LONG-TERMS RESULTS IN CHILDREN WITH MASSIVE BONE OSTEOARTICULAR ALLOGRAFTS OF THE KNEE FOR HIGH-GRADE OSTEOSARCOMA.
No full textOsteoid osteoma. Direct visual identification and intralesional excision of the nidus with minimal removal of bone
No full textElectrochemotherapy to metastatic spinal melanoma: A novel treatment of spinal metastasis?
No full textStudy Design.
Preliminary report of new antitumor treatment.
Objective.
To evaluate the effectiveness of electrochemotherapy as a novel treatment of spinal metastasis.
Summary of Background Data.
Electrochemotherapy is a new antitumor treatment that combines systemic bleomycin with electric pulses delivered locally at the tumor site. These electric pulses permeabilize cell membranes in the tissue, allow bleomycin delivery diffusion inside the cells, and increase bleomycin cytotoxicity. Previous clinical studies have demonstrated the effectiveness of electrochemotherapy in the treatment of several primary and metastatic solid tumors.
Methods.
Treatment planning for electrode positioning and electrical pulse parameters was prepared for 4 needle electrodes. Mini-open surgery with a left L5 laminectomy was performed to introduce the eletrodes. The patient was treated according to the established Electrochemotherapy Protocol with Bleomycin. Clinical efficacy of electrochemotherapy was evaluated according to a visual analog scale of pain, Oswestry Disability Index 2.0, the Karnofsky Performance Scale, and Response Evaluation Criteria in Solid Tumors.
Results.
The assessed follow-up period was 48 months after the electrochemotherapy procedure. Neither serious electrochemotherapy-related adverse events, nor bleomycin toxicity were reported. Overall improvement in pain according to Oswestry Disability Index 2.0 and Karnofsky Performance Scale outcomes was better.
Conclusion.
Our case represents, to our knowledge, the first one to test the potential role of electrochemotherapy as treatment of spinal metastasis. Electrochemotherapy allowed a successful treatment of metastatic spinal melanoma. However, we believe that there is a strong scientific rationale to support the potential utility of electrochemotherapy as a novel treatment of spinal metastasis, regardless of the histological types.
Level of Evidence:
- …
