1,721,017 research outputs found
Statins, fracture risk, and bone remodeling
No full textStatins inhibit HMG-CoA reductase and reduce the intracellular formation of mevalonate. They are chemical compounds able to reduce total cholesterol by 15-40% and LDL cholesterol by 20-60%, and to increase HDL cholesterol by 5-15%. They also reduce triglycerides by 10- 30%. Statins, blocking the mevalonate pathway, inhibit the prenylation of proteins, which is essential to perform their biological function. A great deal of research has documented the positive effect of statins on bone formation and the importance of bone morphogenetic protein-2 (BMP-2) in mediating this effect. Statins are also able to decrease osteoblast apoptosis. The positive effect of statins on bone formation is accompanied by an inhibition of osteoclast activity, which gives statins the ability to uncouple the bone remodeling processes. Patients taking statins have a higher femoral bone density than those who do not. The lipophilic statins seem to be more effective than the hydrophilic statins in protecting bone. In several clinical trials, but not in all, the use of statins had been associated with a reduction in the fracture risk. In conclusion, statins have a positive effect on bone in vitro, but such an efficacy in humans has yet to be clearly demonstrated. Randomized, controlled trials are needed to provide a satisfactory answer on this issue
Osteocalcin and bone specific alkaline phosphatase in healthy subjects with osteopenia and patients with insulin-dependent diabetes mellitus
No full textOxidative stress, bone mineral density, and bone formation markers in postmenopausal women with osteoporosis: a case-control study
No full textBone mineral density improvement after successful parathyroidectomy in pre- and postmenopausal women with primary hyperparathyroidism. A prospective study.
No full textBone mineral density, bone formation and oxidative stress markers in postmenopausal women with osteoporosis: a case-control study
No full textHypercalcemia, hyperparathyroidism, calcium, PTH, PTHrP, parathyroid glands, vitamin D, parathyroid tumors, parathyroidectomy, hypertension, calcemia, BMD, bone mineral density, ALP, alkaline phosphatase, bone marker
Changes of bone formation markers osteocalcin and bone specific alkaline phosphatase in postmenopausal women with osteoporosis
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Relationship between arterial blood pressure, calcemia and PTH in postmenopausal patients with primary hyperparathyroidism
No full textPrimary hyperparathyroidsm in the elderly. Does the disease differ in respect to younger patients ?
No full textBone organic matrix components: their roles in skeletal physiology
No full textBone matrix is composed mainly of inorganic materials, while the bone organic compartment is a minor and complex structural entity, surrounding and supporting cells. Three major classes of biomolecules are involved in this organic part: structural proteins, specialized proteins, and proteoglycans. This review will briefly summarize our knowledge about the role and regulation of these specific bone components
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