24 research outputs found
Wind-tunnel study of block 259 building, Houston
No full textCER78-79JEC-JAP-AK18.Prepared for Colaco Engineers, Inc.Includes bibliographical references (pages 32-33).January 1979
A Monte Carlo Simulation Study on Adsorption of Nitrogen Oxides (NOx) in zeolites
No full textNitrogen oxides (NOx) are significant sources of air pollution. Nitrogen oxides like Nitric oxide (NO) and Nitrogen dioxide (NO2) are mainly responsible for the acid rain and smog. Nitrous oxide (N2O), also known as the laughing gas, is the major greenhouse gas that is responsible for the ozone layer's damage in the troposphere. According to the Environmental Protection Agency (EPA) report, one pound of N2O is 300 times more potent greenhouse gas than one pound of CO2. The significant emitters of Nitrogen oxides (NOx) are automobiles, agricultural sources, thermal power plants, and chemical processes like Nitric acid production plants, paint manufacturing, etc. This study mainly focuses on the tail gas emitted from the Nitric acid production facility. The tail gas emitted during the HNO3 production consists of almost 2% of O2, 200-400 ppm of NO2, and NO, whereas 800 ppm of N2O. As N2O is the most emitted gas from the Nitric acid production facility, it is followed by NO2 and NO, so it is essential to reduce these pollutants from the tail gas. Selective catalytic reduction (SCR) is a well-known technique currently involved in reducing NOx via the adsorption process from the Nitric acid production facility. But the costs involved in these methods are quite high. Nanoporous materials like zeolite exhibit uniform pore size and high thermal stability are said to be the promising adsorbents of NOx. The availability of a large number of zeolites makes it impossible to identify the proper zeolite for NOx adsorption experimentally. In such situations, molecular simulations are a powerful tool that can help identify the perfect zeolite. The time and cost involved in the process of molecular simulations are very low. In this work, Monte Carlo simulations involving reaction ensemble are implemented to obtain the equilibrium composition of NOx components at desired operating conditions in the Brick molecular simulation package. This is followed by Grand Canonical Monte Carlo simulations (GCMC) and Reactive Grand Canonical Monte Carlo simulations (RXMC-GCMC) for pure and quaternary NOx gas mixture adsorption in five different zeolites (FAU, FER, MOR, MFI, and TON) using simulation package RASPA. The composition results from the reaction ensemble are validated with the composition results obtained using the Gibbs minimization technique in the MATLAB model, and the results are in good agreement. The quaternary gas mixture adsorption results in five different frameworks from RXMC-GCMC simulations are then validated in Ideal adsorbed solution theory in the Python model, and the results are in good agreement at the given operating conditions. </p
Inositol is a constituent of detergent-solubilized immunoaffinity-purified rat liver 5′-nucleotidase
No full textmyo-Inositol analysis of detergent-solubilized immunoaffinity-purified rat liver 5'-nucleotidase showed the presence of 1 mol of myo-inositol/mol of enzyme monomer. This provides unequivocal evidence that the ectoenzyme 5'-nucleotidase is attached to liver membranes by a glycosyl-phosphatidylinositol lipid anchor.</p
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Vaccine glycoproteins tagged with the human Fc domain as second generation vaccine candidates
No full textTraditional vaccines such as inactivated or live attenuated vaccines, are gradually giving way to more biochemically defined vaccines that are most often based on a recombinant antigen known to possess neutralizing epitopes. Such vaccines can offer improvements in speed, safety and manufacturing process but an inevitable consequence of their high degree of purification is that immunogenicity is reduced through the lack of the innate triggering molecules present in more complex preparations. Targeting recombinant vaccines to antigen presenting cells (APCs) such as dendritic cells however can improve immunogenicity by ensuring that antigen processing is as efficient as possible. Immune complexes, one of a number of routes of APC targeting, are mimicked by a recombinant approach, crystallizable fragment (Fc) fusion proteins, in which the target immunogen is linked directly to an antibody effector domain capable of interaction with receptors, FcR, on the APC cell surface. A number of virus Fc fusion proteins have been expressed in insect cells using the baculovirus expression system and shown to be efficiently produced and purified. Their use for immunization next to non-Fc tagged equivalents shows that they are powerfully immunogenic in the absence of added adjuvant and that immune stimulation is the result of the Fc-FcR interaction
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Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines
No full textThe hemagglutinins (HAs) of human H1 and H3 influenza viruses and avian H5 influenza virus were produced as recombinant fusion proteins with the human immunoglobulin Fc domain. Recombinant HA-human immunoglobulin Fc domain (HA-HuFc) proteins were secreted from baculovirus-infected insect cells as glycosylated oligomer HAs of the anticipated molecular mass, agglutinated red blood cells, were purified on protein A, and were used to immunize mice in the absence of adjuvant. Immunogenicity was demonstrated for all subtypes, with the serum samples demonstrating subtype-specific hemagglutination inhibition, epitope specificity similar to that seen with virus infection, and neutralization. HuFc-tagged HAs are potential candidates for gene-to-vaccine approaches to influenza vaccination
