1,694 research outputs found
Changing patterns of dengue epidemiology and implications for clinical management and vaccines.
No full textCameron Simmons and Jeremy Farrar discuss the changing patterns of dengue epidemiology and the implications for clinical management and vaccines, drawing upon a recent study by Derek Cummings and colleagues in Thailand
Under the kerosene lamp : being the prairie pioneer's primer / by Harry P. Simmons ; with photographs by the author.
No full text223 p.
Roper v. Simmons and Our Constitution in International Equipoise
No full textIn Roper v. Simmons, the Court unequivocally affirms the use of comparative constitutionalism to interpret the Eighth Amendment. It does not, however, provide an obvious theoretical basis to justify the practice. This Article searches for a theory to explain the comparativism in Roper using the theories advanced in the author\u27s previous scholarship. It concludes that of the colorable candidates, natural law constitutionalism is the most plausible explanation, with the attendant problems associated therewith. The Article concludes with an analysis of the possible ramifications of the Court\u27s comparative approach, suggesting that it may be pursuing a Constitution that is in international equipoise, with international values distributed liberally throughout our jurisprudence to ensure foreign and domestic equilibrium. comparative, constitution, international, roper, simmons, lawrence, death penalty, eighth amendment, constitutional comparativis
Learning Economics by Servicing: a Mexican Experience of Service-Learning in Microenterprises
No full textThis paper presents an experience of a service learning program in underprivileged Microenterprises. An aspect that turns out to be original as compared to other contributions in literature is the explicit assessment of the impact of the program on the enterprises, since most of the related studies focus on evaluating the students experience and impact on learning derived from participation. The paper suggests that service learning programs with the participation of college students can play an important role both in supporting disadvantaged microenterprises and in providing meaningful learning experiences to students.
Polymer-based treatments to control runoff, leachate and erosion from engineered slopes at Simfer Mine, Guinea, Africa
No full textIt is necessary to understand the erodibility and hydrological response of mine-site slope forming materials (SFMs), because of increasing awareness of the environmental impacts of mining. Steep engineered slopes in high intensity rainfall environments present a serious erosion risk. Temporary surface stabilisers, such as polyacrylamides (PAMs) and polyvinylacrylic latex (PVALs) are potentially cost effective erosion control solutions. In this study PAM and PVAL efficacy to reduce runoff, leachate and erosion was assessed at two application rates, with and without gypsum on SFMs from an iron ore mine in Guinea (West Africa). NSPASS (near-surface photogrammetry assessment of slope forming materials’ surface roughness) is a novel method that integrates digital image capture and GIS. It is shown to detect and quantify surface micro-relief changes of 2-3 mm, not visible to the naked eye.
As expected, soil and non-soil SFMs were significantly different in terms of their physical and chemical properties. Phase I of the study investigated the erodibility of ten SFMs, including soil, ore and waste-rock. The results indicate that the hydrological response to rainfall of most SFMs is to generate leachate. Weathered phyllite (PHY-WEA) is the most erodible SFM by both runoff and leachate. Multiple regression analysis demonstrated that magnetic susceptibility, mineralogy and dry aggregate distribution; parameters not commonly assessed in erosion studies, are important in explaining SFM erodibility and hydrological response.
Phase II evaluated critically the effectiveness of three commercially available polymer solutions (two PAMs and one PVAL) at reducing runoff, leachate and erosion from four of the most erodible SFMs identified in Phase I. The results indicate that some PAM and PVAL treatments significantly reduce runoff, leachate and erosion. Polymer efficacy is highly dependent on the physical and chemical properties of the SFM, as well as the mechanism of polymer to SFM adsorption. Increasing the application rate of select treatments lowered leachate volumes, runoff and leachate total sediment loads. Contrary to previous studies, gypsum amendments did not significantly improve polymer efficiency.
This research has added to our understanding of the erodibility and hydrological response of soil and non-soil SFMs. This is the first study to evaluate critically the efficacy of PVALs in controlling erosion from mine-site SFMs. Future studies should continue to optimise NSPASS performance in monitoring changes in surface micro-relief
Florist's vade mecum [electronic resource] : being a choice collection of whatever worthy notice hath been extant, for the propagation, raising, planting, increasing and preserving the rarest flowers and plants, that our climate and skill (in mixing, making and meliorating apted soils to each species) will perswade to live with us : with several new experiments, for raising new varieties, for their most advantageous management, in a more particular method, than ever yet published : to which is added, The gardener's almanack, remembring and directing him what to do each month throughout the year, in both orchard and flower-garden /
No full textSpecial t.p. : The gardeners almanack for five years / by Samuel Gilbert. London : Printed for Thomas Simmons, 1682.Engraved frontispiece of author opposite t.p.Includes index.Advertisement: p. [19]-[22] at end.Pages 121-130 lacking; numerous errors in paging.Imperfect: tightly bound and stained, with some fading and loss of print.Reproduction of original in the British Library.WingElectronic reproduction
The biology and conservation of the Damara Tern in Namibia
No full textThe globally Near-threatened Damara Tern Sterna balaenarum is little known and faces several conservation issues. The aim of this study was to provide a description of the ecology and numbers of the species and discuss conservation management plans that will effectively ensure its survival
Dengue diagnostics and therapeutic interventions in Viet Nam
No full textDengue is a major public health problem that affects tens of millions of people annually in tropical and sub-tropical countries. This acute viral infection happens to be severe and even life threatening but there is still no available drug or vaccine. Previous studies have noted early higher viral burden in patients who develop more severe symptoms suggesting that administration of a potent and safe antiviral may prevent progression to severe dengue. To verify this hypothesis, we have conducted the first RCT directed towards reducing the viral burden in vivo by administrating chloroquine (CQ), a cheap and well-tolerated drug that inhibits DENV in vitro with concentrations achievable in vivo, to 307 Vietnamese adults with suspected dengue (257 of them were laboratory-confirmed cases). Unfortunately, we did not see an effect of CQ on the duration of infection. However in patients treated with CQ, we observed a trend towards a lower incidence of severe forms. We did not find any differences in the immune response that can explain this trend. We also found more adverse events, primarily vomiting, with CQ. In addition, we have explored the relationships between clinical features, antibody responses and virological markers in these patients. We found that the early magnitude of viremia is positively associated with disease severity and there are serotype dependent differences in infection kinetics. We found as well that DENV was cleared faster and earlier in patients with secondary infections. To complete this study, we have also evaluated 2 rapid lateral flow tests for the diagnosis of dengue in a panel of plasma samples from 245 RT-PCR confirmed dengue patients and 47 with other febrile illnesses. Our data suggest that the NS1 test component of these tests are highly specific and have similar levels of sensitivity (~60%). Both NS1 assays were significantly more sensitive for primary than secondary dengue. The IgM parameter in the SD Duo test improved overall test sensitivity without compromising specificity. All these findings are of major importance for further anti-viral drug testing
The pathogenesis of dengue.
No full textDengue is an important cause of childhood and adult morbidity in Asian and Latin American countries and its geographic footprint is growing. The clinical manifestations of dengue are the expression of a constellation of host and viral factors, some acquired, others intrinsic to the individual. The virulence of the virus plus the flavivirus infection history, age, gender and genotype of the host all appear to help shape the severity of infection. Similarly, the characteristics of the innate and acquired host immune response subsequent to infection are also likely determinants of outcome. This review summarises recent developments in the understanding of dengue pathogenesis and their relevance to dengue vaccine development
'Sorry to have kept you waiting so long, Mr Macfarlane': Further education after the Coalition
No full textThis chapter focuses on the further education (FE) sector in England. Initially it gives an overview of the ‘condition’ of the FE sector and summarises of some of the main characteristics of the current Government’s approach to further education. The chapter locates the Coalition’s position on FE, and some of the key initiatives associated with this stance, within a broader social, economic and cultural context, before turning to the future of further education. Whilst I acknowledge that much will need to be done across all sectors of education after the Coalition loses power, it is argued that no one part of the education system – if indeed system is the correct term – operates in isolation; and that FE’s role and remit is strongly influenced, not only by the nature of the labour market and the economy more broadly, but by the relative status and position of universities, schools and other providers of education and training. Drawing on the ideals of the comprehensive movement and some of the recommendations made in the first draft of the often forgotten Macfarlane Report, the remainder of the chapter provides a vision for further education after the coalition by arguing that FE needs to be repositioned at the heart of a coherent system of tertiary education and play a key role in integrating academic with vocational learning. It finishes by offering a critical overview of the far-reaching cultural, structural and curricular changes that would be required, not only within the further education sector, but across other parts of the compulsory and post-compulsory education system, in order to enable this
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