229 research outputs found
Socioeconomic Influence on the Health of Older People: Estimates Based on Two Longitudinal Surveys
No full textThere is a strong positive relationship between socioeconomic status (SES) and health, but identifying the direction of causation is difficult. This study exploits the longitudinal nature of two Canadian surveys, the Survey of Labour and Income Dynamics and the National Population Health Survey, to study the link from SES to health. For people aged 50 and older who are initially in good health we examine whether changes in health status over the next two to four years are related to prior SES, as represented by income and education. Although the two surveys were designed for quite different purposes the evidence they yield with respect to the probability of remaining in good health is strikingly similar. Both suggest that SES does play a role, that the differences across SES groups are quantitatively significant, that the differences increase with age, and that they are much same for men and women.health; socioeconomic status; SLID; NPHS
The Social Cost-of-Living: Welfare Foundations and Estimation
No full textWe present a new class of social cost-of-living indices and a nonparametric framework for estimating these and other social cost-of- living indices. Common social cost-of-living indices can be understood as aggregator functions of approximations of individual cost-of-living indices. The Consumer Price Index (CPI) is the expenditure-weighted average of first-order approximations of each individual’s cost-of-living index. This is troubling for three reasons. First, it has not been shown to have a welfare economic foundation for the case where agents are heterogeneous (as they clearly are.) Second, it uses an expenditure-weighted average which downweights the experience of poor households relative to rich households. Finally, it uses only first-order approximations of each individual’s cost-of-living index, and thus ignores substitution effects. We propose a “common-scaling” social cost-of-living index, which is defined as the single scaling to everyone’s expenditure which holds social welfare constant across a price change. Our approach has an explicit social welfare foundation and allows us to choose the weights on the costs of rich and poor households. We also give a unique solution for the welfare function for the case where the weights are independent of household expenditure. A first order approximation of our social cost-of- living index nests as special cases commonly used indices such as the CPI. We also provide a nonparametric method for estimating second- order approximations (which account for substitution effects).Inflation, Social cost-of-living, Demand, Average Derivatives
The Social Cost-of-Living: Welfare Foundations and Estimation
No full textWe present a new class of social cost-of-living indices and a nonparametric framework for estimating these and other social cost-of-living indices. Common social cost-of-living indices can be understood as aggregator functions of approximations of individual cost-of-living indices. The Consumer Price Index (CPI) is the expenditure-weighted average of first-order approximations of each individual’s cost-of-living index. This is troubling for three reasons. First, it has not been shown to have a welfare economic foundation for the case where agents are heterogeneous (as they clearly are.) Second, it uses an expenditure-weighted average which downweights the experience of poor households relative to rich households. Finally, it uses only first-order approximations of each individual’s cost-of-living index, and thus ignores substitution effects. We propose a “common-scaling” social cost-of-living index, which is defined as the single scaling to everyone’s expenditure which holds social welfare constant across a price change. Our approach has an explicit social welfare foundation and allows us to choose the weights on the costs of rich and poor households. We also give a unique solution for the welfare function for the case where the weights are independent of household expenditure. A first order approximation of our social cost-of-living index nests as special cases commonly used indices such as the CPI. We also provide a nonparametric method for estimating second-order approximations (which account for substitution effects).Inflation, Social cost-of-living, Demand, Average derivatives
Release of chromatin extracellular traps by phagocytes of Atlantic salmon, Salmo salar (LINNAEUS, 1758)
No full textNeutrophils release chromatin extracellular traps (ETs) as part of the fish innate immune response to counter the threats posed by microbial pathogens. However, relatively little attention has been paid to this phenomenon in many commercially farmed species, despite the importance of understanding host-pathogen interactions and the potential to influence ET release to reduce disease outbreaks. The aim of this present study was to investigate the release of ETs by Atlantic salmon (Salmo salar L.) immune cells. Extracellular structures resembling ETs of different morphology were observed by fluorescence microscopy in neutrophil suspensions in vitro, as these structures stained positively with Sytox Green and were digestible with DNase I. Immunofluorescence studies confirmed the ET structures to be decorated with histones H1 and H2A and neutrophil elastase, which are characteristic for ETs in mammals and other organisms. Although the ETs were released spontaneously, release in neutrophil suspensions was stimulated most significantly with 5 μg/ml calcium ionophore (CaI) for 1 h, whilst the fish pathogenic bacterium Aeromonas salmonicida (isolates 30411 and Hooke) also exerted a stimulatory effect. Microscopic observations revealed bacteria in association with ETs, and fewer bacterial colonies of A. salmonicida Hooke were recovered at 3 h after co-incubation with neutrophils that had been induced to release ETs. Interestingly, spontaneous release of ETs was inversely associated with fish mass (p<0.05), a surrogate for age. Moreover, suspensions enriched for macrophages and stimulated with 5 μg/ml CaI released ET-like structures that occasionally led to the formation of large clumps of cells. A deeper understanding for the roles and functions of ETs within innate immunity of fish hosts, and their interaction with microbial pathogens, may open new avenues towards protecting cultured stocks against infectious diseases
CASSCF calculations for photoinduced processes in large molecules: Choosing when to use the RASSCF, ONIOM and MMVB approximations
No full text25/09/12 meb, Author version attached, OK to pub.In this article, we compare and contrast the RASSCF, ONIOM and MMVB electronic structure methods for calculating relaxation paths on potential energy surfaces of the excited states of large molecules, and for locating any resulting conical intersections at which nonadiabatic decay can take place. Each method is treated here as an approximation to CASSCF, which we choose as our reference level of theory, but which becomes prohibitively expensive computationally for large molecules. Both MMVB and ONIOM are hybrid computational methods – combining different levels of theory in an energy plus derivatives calculation at a particular molecular geometry – but they differ fundamentally in that MMVB is a hybrid-atom method, whereas ONIOM is a hybrid-molecule method. We explain this distinction through four representative applications: the photostability of pyracylene (studied with CASSCF, RASSCF, MMVB); large geometry changes in the singlet excited states of triangulene (studied with MMVB); a model for interstitial nickel defects in a synthetic diamond lattice (studied with ONIOM CAS:UFF); and the photochemical [4 + 4] cycloaddition of cyclohexadiene to naphthalene (studied with ONIOM CAS:MMVB). We show that each method is more appropriate for a particular type of photochemical problem. This article is part perspective, part review, and contains new results for three multi-state or photoinduced processes in complex systems
Non-steroidal anti-inflammatory drugs, prostaglandins and COVID-19
No full textSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the novel coronavirus disease 2019 (COVID-19), a highly pathogenic and sometimes fatal respiratory disease responsible for the current 2020 global pandemic. Presently, there remains no effective vaccine nor efficient treatment strategies against COVID-19. Non-steroidal anti-inflammatory drugs (NSAIDs) are medicines very widely used to alleviate fever, pain and inflammation (common symptoms of COVID-19 patients) through effectively blocking production of prostaglandins (PGs) via inhibition of cyclooxygenase enzymes. PGs can exert either pro- or anti-inflammatory effects depending on the inflammatory scenario. In this review, we implicate the potential roles that NSAIDs and PGs may play during SARS-CoV-2 infection and the development and progression of COVID-19.<br/
Home Cooking, Food Consumption and Food Production among the Unemployed and Retired Households
No full textUtilizing the 1996 Canadian Food Expenditure survey matched with Canadian Nutrient File, we separate actual food consumption from observed expenditure and test the Permanent Income/Life Cycle Hypothesis on the true consumption data. We find that the lower food expenditure during periods of unemployment or retirement (previously reported in the literature), does not translate into poorer nutrition. Household calorie intake and major nutrient intake seem to be unaffected by changes in employment status. We find evidence that unemployed or retired households substitute food purchased from restaurants for food purchased for at home consumption. Further, with the 1998 Time Use Survey we find that individuals who are not employed devote more time for food preparation. Finally we present limited evidence that unemployed and retired households substitute precooked meals for meals made from primary ingredients.Food Production, Nutrition, Consumption Smoothing
The Economic Legacy of Divorced and Separated Women in Old Age
No full textAlthough progress has been made over the last 20 years, the burden of a low income in old age is still carried by unattached women. Few researchers, however, have examined exactly where the burden of poverty falls within the category of unattached older women or the nature of this poverty. Like any other group of older Canadians, unattached women are not a homogenous population. The category of 'unattached' includes the separated, divorced, widowed and ever single, all of whom face different circumstances in old age because of differences over the life course. Using SLID data we examine income and sources of income from 1993 to 1999 to identify differences among these groups. The findings indicate that the separated and divorced are the poorest of all older unattached women in Canada. A key source of the difference is the growth in private pension incomes.low income; old age; unattached women; SLID
Welfare Restructuring without Partisan Cooperation: The Role of Party Collusion in Blame Avoidance
No full textThis article argues that welfare state restructuring, which is highly unpopular among voters, is politically feasible if government and opposition parties collude informally with each other. Contrary to key arguments made in the literature, restructuring does not require the formation of a formal grand coalition which diffuses blame from voters. Party collusion is a distinctive blame-avoiding strategy that differs not only from other party-oriented strategies such as building a grand coalition, but also from voter-oriented ones. By analyzing the politics of pension reform in Germany from 1995 to 2004, this article shows that party collusion, which emerges through repeated signaling and informal agreements, enables political parties to restructure the welfare state without running the risk of electoral failure. Finally, it suggests that collusion likely explains recent successes of Austrian, French and Italian governments in legislating unpopular welfare cutbacks.political parties, blame avoidance, collusion, welfare state, pension policy
The Economic Legacy of Divorced and Separated Women in Old Age
No full textAlthough progress has been made over the last 20 years, the burden of a low income in old age is still carried by unattached women. Few researchers, however, have examined exactly where the burden of poverty falls within the category of unattached older women or the nature of this poverty. Like any other group of older Canadians, unattached women are not a homogenous population. The category of "unattached" includes the separated, divorced, widowed and ever single, all of whom face different circumstances in old age because of differences over the life course. Using SLID data we examine income and sources of income from 1993 to 1999 to identify differences among these groups. The findings indicate that the separated and divorced are the poorest of all older unattached women in Canada. A key source of the difference is the growth in private pension incomes.low income; old age; unattached women; SLID
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