1,081 research outputs found
Arkansas Vernacular Architecture Manuscript Vernacular Building Type List and Sketches
No full textHandwritten ink building type list with building elevation sketches.Of particular note is Sutherland's use of the term "duple" for the double pen house. Author Donald Harington is credited with coining the term, and Sutherland with popularizing it
Interview with YA author and Children‘s Editorial Assistant Suzanne Sutherland
No full textAn interview with Young Adult author Suzanne Sutherland. The interview focuses on Toronto, the straight edge scene, music and subculture, Sutherland\u27s first book, When We Were Good and the importance of queer representation in YA books. Sutherland also recommends a number of YA novels
HERStory Makers 2022: Emmajay Sutherland
No full textEmmajay Sutherland is a PhD candidate at the University of St Andrews studying development of anti-cancer drugs from environmental sources. She took part in HERStory Makers 2022.What is HERStory Makers?HERStory Makers is a social media competition for female-identifying early career researchers to share their research, their career journeys, and to inspire the next generation. Winners are selected by public vote. HERStory Makers is also part of EXPLORATHON, Scotland's contribution to European Researchers' Night.In 2022-23, EXPLORATHON was supported by the Engineering & Physical Sciences Research Council [grant number EP/X020762/1].Author contributions to contentEmmajay Sutherland conceived, planned, and recorded the video content. Kirsty Ross edited the video content to insert HERStory Maker credits, add subtitles, and maintain video length below Twitter/X limit of 2 mins and 20 secs, prior to scheduling the social media posts.</p
Jean Sutherland
No full textPhotograph - Jean Sutherland with a toy bear and covered wagon, Athabasca, Albert
Sutherland and the Canadian Pacific Railway
No full textNotes - Memoirs by Ella Rita Zakariasen focusing on growing up in Sutherland, Saskatchewan (13 pages)Memoir
Underemployment : a skills utilisation perspective
No full textMore than half of all employees believe that the skills they possess are higher than those required to do their present jobs. This is one of several findings reported in a research paper on "under-employment" in the current edition of the University of Strathclyde's Fraser of Allander Review published today. According to the author of the paper, John Sutherland of the Scottish Centre for Employment Research at the university, this provides further evidence that "under-employment" is as important a policy problem as "unemployment"
Authentic Account of the Chinese Commission, which was sent to report on the Great Exhibition
No full textpage, frontispiec
Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels
No full textLeptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to functional outputs are unclear at present. A previous study has established that leptin inhibits the activity of the phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome 10), an important tumor suppressor and modifier of phosphoinositide signaling. In this study we demonstrate that leptin phosphorylates multiple sites on the C-terminal tail of PTEN in hypothalamic and pancreatic beta-cells, an action not replicated by insulin. Inhibitors of the protein kinases CK2 and glycogen synthase kinase 3 (GSK3) block leptin-mediated PTEN phosphorylation. PTEN phosphorylation mutants reveal the critical role these sites play in transmission of the leptin signal to F-actin depolymerization. CK2 and GSK3 inhibitors also prevent leptin-mediated F-actin depolymerization and consequent ATP-sensitive K+ channel opening. GSK3 kinase activity is inhibited by insulin but not leptin in hypothalamic cells. Both hormones increase N-terminal GSK3 serine phosphorylation, but in hypothalamic cells this action of leptin is transient. Leptin, not insulin, increases GSK3 tyrosine phosphorylation in both cell types. These results demonstrate a significant role for PTEN in leptin signal transmission and identify GSK3 as a potential important signaling node contributing to divergent outputs for these hormones.</p
North by East piece on Portland author Amy Sutherland, who promoted her book,
No full textNorth by East piece on Portland author Amy Sutherland, who promoted her book, Kicked, Bitten, and Scratched: Life and Lessons at the Premier School for Exotic Animal Trainers, by writing a column for the New York Times on how she used animal behaviour modification techniques on her husband. The column was so popular she has a deal to expand it into a book
Justice Sutherland Reconsidered
No full textIn the annals of Supreme Court history, George Sutherland occupies a curious place. Associate Justice of the U.S. Supreme Court from 1921 to 1938, the Utah native has long been identified as one of the infamous Four Horsemen, known largely for his role as a judicial conservative instrumental in the Court\u27s invalidation of significant aspects of the New Deal. Yet Sutherland was also the author of several influential opinions involving matters as diverse as civil rights, freedom of expression, and others that recognized the broad authority of the federal government in the realm of foreign and military affairs. A proponent of limited government intervention into private economic activities, he also advocated the public interest in the exercise of reasonable controls of private land use. Moreover, Sutherland did not hesitate to support workers\u27 compensation and other exercises of governmental authority intended to promote the public welfare. Accordingly, Justice Sutherland might appear to the modern observer as somewhat of a judicial enigma, who, except for an occasional progressive lapse, more often than not, imbued his analysis reference in print to Sutherland and his fellow bloc of dissenters on the Hughes Court
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