196,140 research outputs found
"Il Lembo di Gastrocnemio nella Chirurgia dei Sarcomi del Ginocchio"
No full textIl Lembo di Gastrocnemio nella Chirurgia dei Sarcomi del Ginocchi
Vascularized Fibula as Salvaging Procedure in Failed Femoral Allografts
No full textVascularized Fibula as Salvaging Procedure in Failed Femoral Allograft
Anti-Inflammatory Dysidazirine Carboxylic Acid from the Marine Cyanobacterium Caldora sp. Collected from the Reefs of Fort Lauderdale, Florida
No full textDysidazirine carboxylic acid (1) was isolated from the lipophilic extract of a collection of the benthic marine cyanobacterium Caldora sp. from reefs near Fort Lauderdale, Florida. The planar structure of this new compound was determined by spectroscopic methods and comparisons between HRMS and NMR data with its reported methyl ester. The absolute configuration of the single chiral center was determined by the conversion of 1 to the methyl ester and the comparison of its specific rotation data with the two known methyl ester isomers, 2 and 3. Molecular sequencing with 16S rDNA indicated that this cyanobacterium differs from Caldora penicillata (Oscillatoriales) and represents a previously undocumented and novel Caldora species. Dysidazirine (2) showed weak cytotoxicity against HCT116 colorectal cancer cells (IC50 9.1 µM), while dysidazirine carboxylic acid (1) was non-cytotoxic. Similar cell viability patterns were observed in RAW264.7 cells with dysidazirine only (2), displaying cytotoxicity at the highest concentration tested (50 µM). The non-cytotoxic dysidazirine carboxylic acid (1) demonstrated anti-inflammatory activity in RAW264.7 cells stimulated with LPS. After 24 h, 1 inhibited the production of NO by almost 50% at 50 µM, without inducing cytotoxicity. Compound 1 rapidly decreased gene expression of the pro-inflammatory gene iNOS after 3 h post-LPS treatment and in a dose-dependent manner (IC50 ~1 µM); the downregulation of iNOS persisted at least until 12 h
Emoglobina instabile nella tartaruga marina Caretta caretta
No full textL'indagine elettroforetica della emoglobina di esemplari di caretta caretta ha rivelato la presenza di tre frazioni di emoglobina instabile
Knee reconstruction after bone tumor resection in children
No full textKnee reconstruction after bone tumor resection in childre
"Microvascular Free Flaps for Repair of Soft Tissue Oncological Resections"
No full textMicrovascular Free Flaps for Repair of Soft Tissue Oncological Resection
Osteoarticular Allografts in Bone Tumour Surgery ñ Analysis of Complications
No full textOsteoarticular Allografts in Bone Tumour Surgery ñ Analysis of Complication
Complications in massive osteoarticular allograft
No full textComplications in massive osteoarticular allograf
Vascularized Fibula as a Salvage Procedure in fractured allografts
No full textVascularized Fibula as a Salvage Procedure in fractured allograft
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