5 research outputs found
Traction vasculogenesis: Experimental vessel elongation by traction in rat model
No full textBackground: Microsurgeons may face inadequate vessel length in traumatic or post-resection vascular defects and flap surgery. As tissue regeneration by mechanical forces is possible like in tissue expansion and distraction osteogenesis, we questioned the effect of traction forces on isolated vessels, generated by an internal maxillary distraction device to overcome such problem. Methods: 30 Wistar-Albino rats were randomized in two groups as control and traction. By an internal maxillary distraction device placed subcutaneously to abdominal region, femoral artery and vein of traction group were applied daily traction for 10 days perpendicular to their course. Control group received the same procedure but no traction was applied. Vessel length, blood flow and histologic and microangiographic changes were evaluated on postoperative 11th day. Results: Final length of vessels was found to be higher in the traction group (21.93 mm) compared to control group (12.86 mm). (P = 0.000) Blood-flow patency rate of artery and vein was found 100 % in control group (n = 15) and 80 % in experiment group (n = 12). Microangiographic study showed patent blood flow in both control and traction groups. Histologic evaluation showed vascular wall thickening, perivascular adipocyte and neutrophil infiltration and vein lumen enlargement compared to control group. Conclusion: The preliminary “traction vasculogenesis” technique is found to be a promising technique to gain vessel length in vascular shortness problems. With further studies and refinements this technique may be carried to clinical applications in cases of vascular inadequacy
Pedicle lengthening with traction vasculogenesis: Axial and perforator abdominal island flap model in rat
No full textBackground: Functional vessel elongation is possible with traction vasculogenesis technique. This study questions the effect of traction on pedicle length and flap viability of rat abdominal superficial epigastric and cephalic epigastric perforator flaps. Method: 28 Wistar-Albino rats were divided into 4 groups as superficial epigastric flap control and traction groups and cephalic epigastric perforator flap control and experiment groups. 1 mm daily traction was applied for 10 days to traction subgroups. on the 10th day pedicle length was measured and flaps were raised. 7 days after viable flap areas were measured. Statistical analysis was done. Results: in both superficial epigastric flap and cephalic epigastric perforator flap groups, pedicle length was found to be higher in traction group and flap viability was found to be higher in control groups. No relation was found between pedicle length and flap viability. Discussion: As a novel technique traction vasculogenesis may be applied to flap pedicles for elongation. This elongation process, not surprisingly may reduce the viable flap surface. However, traction vasculogenesis seems promising for functional elongation of axial and perforator flap pedicles under optimal conditions
A systematic review of penile replantations: May it guide us in penile allotransplantation?
No full textIntroduction: Penis replantation cases may serve as a model for identifying important elements in developing clinical penile allotransplantation. Material and Methods: We reviewed 82 published cases of penis replantation. Results: Besides the basic repair of urethra and corpora, we found that dorsal artery and dorsal nerve repair was associated with significantly better sensory return. Deep dorsal vein repair was associated with decreased sensation and increased complication rates. Conclusion: Penile allotransplantation may need to incorporate these findings
Anatomic Basis for Penis Transplantation: Cadaveric Microdissection of Penile Structures
No full textWe present a cadaveric dissection study to investigate the anatomic feasibility of penile transplantation. Seventeen male cadavers were dissected to reveal detailed anatomy of the dorsal neurovascular structures including dorsal arteries, superficial and deep dorsal veins, and dorsal nerves of the penis. Dorsal artery diameters showed a significant decrease from proximal to distal shaft. Dominance was observed in one side. Deep dorsal vein showed a straight course and less decrease in diameter compared to artery. Dorsal nerves showed proximal branching pattern. In a possible penile transplantation, level of harvest should be determined according to the patient and the defect, where a transgender patient will receive a total allograft and a male patient with a proximal penile defect will receive a partial shaft allograft. We designed an algorithm for different levels of penile defect and described the technique for harvest of partial and total penile transplants
