7 research outputs found
The Nmin method in Switzerland: potential for improvement and development in the context of digitalization
No full textEl huracán en la trilogía bananera de Miguel Ángel Asturias
No full textMiguel Ángel Asturias’ trilogy is usually read in the context of the so called novela bananera and its narratives of anti-imperialism and anti-capitalism. Therefore, critics usually take a perspective marked by politics and economy. But the work by the Guatemalan author is also profoundly inscribed in the context of nature and mythology. The present article adopts an ecocritical point of view and offers a new perspective on the trilogy by analyzing one specific meteorological phenomenon, the hurricane. This airy natural manifestation influences the culture and literature of the Caribbean and Central American area, as in the case of Asturias’ trilogy where it is described on different dimensions: the natural, the mythological and – as metaphor – also on the political dimension
Neuroimmune regulation of JCV by immune mediators in glial cells
Get PDF2012 - 2013The human polyomavirus JC (JCV) is a small DNA virus responsible for the initiation of progressive multifocal leukoencephalopathy (PML), an often lethal disease of the brain characterized by lytic infection of oligodendrocytes in the central nervous system (CNS). Patients undergoing immune modulatory therapies for the treatment of autoimmune diseases such as multiple sclerosis, and individuals with an impaired-immune system, most notably AIDS patients, are in the high risk group of developing PML. Previous studies suggested that soluble immune mediators secreted from PBMCs inhibited viral genomic replication. However little is known regarding the molecular mechanism of this regulation. Here we investigated the impact of conditioned media (CM) from activated PBMCs on viral replication and gene expression by molecular virology techniques. Our data showed that viral gene expression as well as viral replication was suppressed by the CM. Further studies revealed that soluble immune mediators from PBMCs possessed a dual control on T-antigen expression at transcription and post-transcription level. These observations demonstrate a novel role of immune mediators in regulation of JCV gene expression, and provide a new avenue of research to understand molecular mechanism of viral reactivation in patients who are at risk of developing PML. [edited by author]XII n.s
Pixel to practice: multi-scale image data for calibrating remote-sensing-based winter wheat monitoring methods
No full textISSN:2052-446
Combined effects of time-restricted eating and exercise on short-term blood glucose management in individuals with Type 2 Diabetes Mellitus: The TREx study, a randomised controlled trial
Get PDFTime-restricted eating (TRE) is a chrono-nutrition strategy where the daily 'eating window' is reduced to 8-10 h. We investigated the acute (14-h) effects of TRE, with and without post-meal exercise, on blood glucose and insulin concentrations in people with type 2 diabetes mellitus. Fourteen participants (5 F, 9 M; HbA1c: 7.6 ± 1.0%) completed four conditions in this randomised crossover study: CON (eating window, 0800-2000 h), CON with exercise (CON + Ex; 0800-2000 h + 15 min walking at 60% VO peak, 45 min post-meal), TRE (eating window 1000-1800 h), and TRE with exercise (TRE + Ex, 1000-1800 h + 15 min walking as per CON + Ex), with standardised meals. Venous blood samples were collected at 26-timepoints and analysed for glucose and insulin concentrations. Statistical analysis used linear mixed-effects models with P < 0.05. Reducing the eating window had little effect on plasma glucose 14-h area under the curve (AUC). Exercise reduced insulin 14-h AUC (P=0.01) with no additive effect of TRE. Post-meal exercise lowered 14-h insulin AUC, neither 8-h TRE nor post-meal exercise altered 14-h blood glucose compared with 12-h eating window. Future work should focus on long-term effects of TRE combined with exercise for enhancing blood glucose in people with type 2 diabetes mellitus. [Abstract copyright: Copyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved.
Author Correction: Continuous scanning for Bragg coherent X-ray imaging (Scientific Reports, (2020), 10, 1, (12760), 10.1038/s41598-020-69678-5)
No full textThis Article contains errors. In Figure 1, the numerical labels for the Log(Intensity) colour scale are in the incorrect position. The correct Figure 1 appears below. (Figure presented.). In Figure 2, three erroneous numerical labels ‘-3.89′, ‘0′ and ‘3.34′ appear above the Strain colour scale. The correct Figure 2 appears below. (Figure presented.)
