376 research outputs found
Distributed human computation framework for linked data co-reference resolution
No full textDistributed Human Computation (DHC) is a technique used to solve computational problems by incorporating the collaborative effort of a large number of humans. It is also a solution to AI-complete problems such as natural language processing. The Semantic Web with its root in AI is envisioned to be a decentralised world-wide information space for sharing machine-readable data with minimal integration costs. There are many research problems in the Semantic Web that are considered as AI-complete problems. An example is co-reference resolution, which involves determining whether different URIs refer to the same entity. This is considered to be a significant hurdle to overcome in the realisation of large-scale Semantic Web applications. In this paper, we propose a framework for building a DHC system on top of the Linked Data Cloud to solve various computational problems. To demonstrate the concept, we are focusing on handling the co-reference resolution in the Semantic Web when integrating distributed datasets. The traditional way to solve this problem is to design machine-learning algorithms. However, they are often computationally expensive, error-prone and do not scale. We designed a DHC system named iamResearcher, which solves the scientific publication author identity co-reference problem when integrating distributed bibliographic datasets. In our system, we aggregated 6 million bibliographic data from various publication repositories. Users can sign up to the system to audit and align their own publications, thus solving the co-reference problem in a distributed manner. The aggregated results are published to the Linked Data Cloud
Detection of Cognitive Features from Web Resources in Support of Cultural Modeling and Analysis
No full textThe World Wide Web serves as a valuable source of culture-relevant information, which can be used to support cultural modeling and analysis activities. Part of the challenge in exploiting the Web as a source of culture-relevant information relates to the need to detect and extract information about beliefs, attitudes, and values from a variety of different resources. The Web thus features a rich variety of information resources, and these are seldom categorized with respect to the dimensions in which cultural analysts are interested. Exploiting the Web as a source of culture-relevant information therefore requires techniques and approaches that enable cultural analysts to extract relevant information and organize extracted content in various ways. In this paper, we outline an approach to assist cultural analysts in the extraction and organization of relevant information. We show techniques that can be used to extract information about the attitudes, beliefs, and values of individuals, and how this data can, in turn, be used to support cultural modeling and analysis
Combustion and Society: A Fire-Centred History of Energy Use
No full textFire is a force that links everyday human activities to some of the most powerful energetic movements of the Earth. Drawing together the energy-centred social theory of Georges Bataille, the fire-centred environmental history of Stephen Pyne, and the work of a number of ‘pyrotechnology’ scholars, the paper proposes that the generalized study of combustion is a key to contextualizing human energetic practices within a broader ‘economy’ of terrestrial and cosmic energy flows. We examine the relatively recent turn towards fossil-fuelled ‘internal combustion’ in the light of a much longer human history of ‘broadcast’ burning of vegetation and of artisanal pyrotechnologies – the use of heat to transform diverse materials. A combustion-centred analysis, it is argued, brings human collective life into closer contact with the geochemical and geologic conditions of earthly existence, while also pointing to the significance of explorative, experimental and even playful dispositions towards energy and matter. © 2014, SAGE Publications. All rights reserved
Journal publishing and author self-archiving: Peaceful Co-Existence and Fruitful Collaboration
No full textThe UK Research Funding Councils (RCUK) have proposed that all RCUK fundees should self-archive on the web, free for all, their own final drafts of all journal articles reporting their RCUK-funded research, in order to maximise their usage and impact. ALPSP (a learned publishers' association) now seeks to delay and block the RCUK proposal, arguing that it will ruin journals. All objective evidence from the past decade and a half of self-archiving, however, shows that self-archiving can and does co-exist peacefully with journals while greatly enhancing both author/article and journal impact, to the benefit of both. Journal publishers should not be trying to delay and block self-archiving policy; they should be collaborating with the research community on ways to share its vast benefits
Parametrization of Peatland Hydraulic Properties for the Canadian Land Surface Scheme
No full textA hydraulic parametrization is developed for peatland environments in the Canadian Land Surface Scheme (CLASS). Three wetland soil classes account for the typical variation in the hydraulic characteristics of the uppermost 0.5 m of organic soils. Review of the literature reveals that saturated hydraulic conductivity varies from a median of 1.0 x 10-7 m/s in deeply humified sapric peat to 2.8 x 10-4 m/s in relatively undecomposed fibric peat. Average pore volume fraction ranges from 0.83 to 0.93. Parameters have been designed for the soil moisture characteristic curves for fibric, hemic and sapric peat using the Campbell (1974) equation employed in CLASS, and the van Genuchten (1980) formulation. There is little difference in modelled soil moisture between the two formulations within the range of conditions normally found in peatlands. Validation of modelled water table depth and peat temperature is performed for a fen in northern Québec and a bog in north-central Minnesota. The new parametrization results in a more realistic simulation of these variables in peatlands than the previous version of CLASS, in which unrealistic mineral soil "equivalents" were used for wetland soil climate modelling. (English) ABSTRACT FROM AUTHOR]; Un paramétrage de nature hydraulique est développé pour des sols organiques du schéma CLASS («Canadian LAnd Surface Scheme»). Trois classes de nouveaux sols de tourbières rendent compte de la variation typique des caractéristiques hydrauliques pour des sols organiques du 0,5 premier mètre. Une revue de la littérature des paramètres hydrauliques révèle que la conductivité hydraulique saturée s'écarte de la médiane de 1,0 x 10-7 m/s pour une tourbe humide saprique profonde jusqu'à 2,8 x 10-4 m/s pour une tourbe fibrique relativement moins décomposée. La porosité moyenne varie de 0,83 à 0,93. Des paramètres ont été développés afin d'obtenir des courbes caractéristiques d'humidité du sol pour la tourbe fibrique, mésique et saprique, en utilisant le schéma de Campbell (1974) et celui de van Genuchten (1980). Aucune différence significative n'a été détectée dans les deux schémas lorsqu'on les utilise dans des conditions normales trouvées dans les tourbes. On a effectué la validation de la modélisation du niveau phréatique et de la température de la tourbe pour une tourbière carex (fen) dans le nord du Québec et une tourbe à sphaigne (bog) dans le centre nord du Minnesota. Le nouveau paramétrage produit une simulation plus réaliste que la version antérieure du schéma CLASS, qui utilisait des paramètres non réalistes du sol minéral pour modéliser le climat du sol humide. (French) ABSTRACT FROM AUTHOR]; Copyright of Atmosphere -- Ocean (Canadian Meteorological & Oceanographic Society) is the property of Canadian Meteorological & Oceanographic Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)19580530Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=edo&AN=19580530&site=eds-live&scope=sit
Novel methodology for the synthesis of ¹³C-Labelled phenols and its application to the total synthesis of polyphenols
No full textElectronic redacted version does not contain associated previously published materialThe base-catalysed reaction of 4H-pyran-4-one with a range of nucleophiles, namely diethyl malonate, ethyl acetoacetate, nitromethane, acetylacetone and ethyl cyanoacetate, was developed as a reliable, high yielding method for the preparation of para-substituted phenols.
The methodology was extended to include the use of the substituted pyranones, maltol, 2,6-dimethyl-4H-pyran-4-one and diethyl chelidonate. Reactions were studied using conventional heating methods and microwave irradiation. Microwave irradiation had definite beneficial effects, with improved yields, reduced reaction times and cleaner reaction profiles.
The potential of this methodology was examined for the regioselective placement of ¹³C-atoms into benzene rings using ¹³C-labelled nucleophiles or ¹³C-labelled 4H-pyran-4-ones. [3,5-13C₂]4H-Pyran-4-one and [2,6-13C₂]4H-pyran-4-one were prepared from various ¹³C-labelled versions of triethyl orthoformate and acetone. This methodology was applied to the synthesis of
[1,3,5-¹³C₃]gallic acid, via the base-catalysed reaction of [3,5-¹³C₂]4H-pyran-4-one with diethyl [2-¹³C]malonate, followed by subsequent transformations to yield [1,3,5-¹³C₃]gallic acid.
The preparation of [2-¹³C]phloroglucinol was carried out via [2-¹³C]resorcinol, with
regioselective placement of a single ¹³C-atom into the aromatic ring. This was accomplished from non-aromatic precursors, with the source of the ¹³C-atom being [¹³C]methyl iodide. The key step in this synthesis was the introduction of the third hydroxyl group, which was achieved using a modified iridium-catalysed C-H activation/borylation/oxidation procedure. The scope of an existing C-H activation/borylation reaction was modified and expanded to include a range of protected resorcinol derivatives. A catalyst system was developed which allowed high conversion to the intermediate arylboronic acids, followed by oxidation using aqueous Oxone®
to yield the corresponding phenols.
Finally, to demonstrate the potential of these new methods for application in the synthesis of isotopically labelled natural products and polyphenols, the syntheses of ¹³C-labelled anthocyanins were studied. A route was developed that could be applied to the synthesis of either cyanidin-3-glucoside or delphinidin-3-glucoside. Only the final coupling/cyclisation step to yield the desired anthocyanin targets remains to be carried out
T Cell responses to whole SARS Coronavirus in humans
No full textEffective vaccines should confer long-term protection against future outbreaks of severe acute respiratory syndrome (SARS) caused by a novel zoonotic coronavirus (SARS-CoV) with unknown animal reservoirs. We conducted a cohort study examining multiple parameters of immune responses to SARS-CoV infection, aiming to identify the immune correlates of protection. We used a matrix of overlapping peptides spanning whole SARS-CoV proteome to determine T cell responses from 128 SARS convalescent samples by ex vivo IFN-γ ELISPOT assays. Approximately 50% of convalescent SARS patients were positive for T cell responses, and 90% possessed strongly neutralizing Abs. Fifty-five novel T cell epitopes were identified, with spike protein dominating total T cell responses. CD8+ T cell responses were more frequent and of a greater magnitude than CD4+ T cell responses (p < 0.001).
Polychromatic cytometry analysis indicated that the virus-specific T cells from the severe group tended to be a central memory phenotype (CD27+/CD45RO+) with a significantly higher frequency of polyfunctional CD4+ T cells producing IFN-γ, TNF-α, and IL-2, and CD8+ T cells producing IFN-γ, TNF-α, and CD107a (degranulation), as compared with the mild-moderate group. Strong T cell responses correlated significantly (p < 0.05) with higher neutralizing Ab. The serum cytokine profile during acute infection indicated a significant elevation of innate immune responses. Increased Th2 cytokines were observed in patients with fatal infection. Our study provides a roadmap for the immunogenicity of SARS-CoV and types of immune responses that may be responsible for the virus clearance, and should serve as a benchmark for SARS-CoV vaccine design and evaluation
Modes of association and differentiation in Mauritius : an account of identity in a situation of socio-cultural heterogeneity
No full textThis Thesis details the anthropological investigation of socio-cultural heterogeneity in Mauritius, a small island republic in the Indian Ocean. I introduce the island, its population, climate and other salient features in the Introduction, where I also reveal something of the author's intentions, interests and ideology.
Although Mauritius has been relatively infrequently written about by anthropologists or other social scientists, when Mauritian social diversity has been discussed it has been conducted on the presumption that difference is synonymous with division. Consequently, in Chapter 1, I develop a critique of this assumption, which has found its way into the texts and discourses of both sociologists and state bureaucrats. I collapse these two categories' products into one, by drawing upon Foucault's notion of 'governmentality', and critique widespread views of Multiculturalism as being founded on the alleged coevalness of difference and division. I also introduce my three main analytical tools: intersubjectivity, transcendence and creolization.
Chapter 2 portrays individuals' identity, agreeing that at times those Mauritians that I met did draw divisions between one another, but that this was far from predictable, nor universally practised. Chapter 3 continues this project, by focusing on specific forms of the expression of division, but again I highlight the unanticipated nature of division and difference. Chapter 4 further clouds the picture by noting that even where individuals might be thought to be unproblematically employing ethnic - or caste - based strategies in, for example, the workplace, the use of such tools was again unforseeable, and not always successful. Even where they were successful in securing advantage, there are wider costs not previously noted in the ethnographic record.
Chapter 5 is the culmination of my argument. Through a fine-grained portrayal of a number of ethnographic moments, I point up the unifying and shared practices which have hitherto been excerpted from ethnographic accounts of Mauritius (or other 'plural' societies). These unifying features are as relevant to my understanding of Mauritian society as divisions, I claim, and I reflect on the contrast between 'banal' unities and governmental notions of Multiculturalism.
The Conclusion draws together the threads of the Thesis and charts where it fits in terms of wider anthropological and political trends
Semiometrics: producing a compositional view of influence
No full textHigh-impact academic papers are not necessarily the most cited. For example, Einstein's 'Special Relativity' paper from 1905 received (and continues to receive) fewer citations from other papers than his 'Brownian Motion" paper of the same year, despite the former radically changing the course of an entire scientific discipline to a much greater extent. Similarly, 'impact' metrics using citation count alone are, it is argued, not adequate for determining the scientific influence of papers, authors or small groups of authors. Although valid, they remain controversial when used to determine influence of larger groups or journals. While the term 'impact' has become closely linked to a journal's citation-based Journal Impact Factor score, this thesis uses the term 'influence' to describe the wider effectiveness of research, combining citation and metadata analysis to allow richer calculations to be performed over large-scale document networks. As a result, more qualitative influence ratings can be determined and a broader outlook on scientific disciplines can be produced. These ratings are best applied using an ontology-based data source, allowing more efficient inference than under a traditional RDBMS system, and allowing easier integration between heterogeneous data sources. These metrics, termed 'Semantic Bibliometrics' or 'Semiometrics', can be applied at a variety of levels of granularity, allowing a compositional framework for impact and influence analysis. This thesis describes the process of data preparation, systems architecture, metric value and data integration for such a system, introducing novel approaches at all four stages, thereby creating a working semiometrics system for determining influence at different semantic levels of granularity
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