323,165 research outputs found
What's in it for me? Capital, value and co-creation practices
No full textMarketing research is increasingly concerned with the practices through which service providers and their customers interact and how these practices influence value co-creation.
Applying S-D logic and drawing on practice theory developed in sociology research in past decades, we propose a definition of value in terms of the coexistence of diverse forms of capital and currency variations. We then develop a conceptual model to explain value co-creation in terms of service provider – customer interaction practices (SPCI practices). We employ an extensive, qualitative study in the context of professional service firms. Our findings reveal three general categories of SPCI practices (access to capital, capital exploitation and capital attrition) that affect value co-creation. These insights move forward business-to-business marketing theory and practice, advancing our understanding of how service provider–customer interaction practices can be used to define value propositions and assess the types and amount of value that are co-created
Il trattamento riabilitativo nelle lesioni sottocutanee del tendine d'Achille The rehabilitative treatment in the subcutaneous lesions of Achilles tendon
No full textTHE COURSE OF THE MICROSOMAL EPOXIDE HYDROLASE-CATALYZED AND ACID-CATALYZED HYDROLYSIS OF (+/-)-2-METHYL-5H-DIBENZO[A,D]CYCLOHEPTENE 10,11-OXIDE
No full textThe HClO4-catalyzed hydrolysis of (+/-)-2-methyl-5H-dibenzo[a,d]cycloheptene 10,11-oxide, 2, has been investigated by HPLC in THF-water and compared with the microsomal epoxide hydrolase (mEH)-catalyzed hydrolysis. While the former reaction gave the trans and cis diols accompanied by large amounts of 9-formyl-2-methyl-9,10-dihydroanthracene, the enzymatic hydrolysis led only to the trans diol 3. The specific activity of the enzyme towards 2 was 2- to 4.4-fold lower than that towards unsubstituted 5H-dibenzo[a,d]cycloheptene 10,11-oxide, and 150 times lower than that towards cis- stilbene oxide. Both the produced diol and the unreacted epoxide recovered from partial hydrolysis of (+/-)-2 were racemic, showing a complete lack of enantioselection by the enzyme, in contrast with the course of the mEH-promoted hydrolysis of ring monosubstituted cis-stilbene oxides. Epoxide 2, a bad substrate for mEH, behaved as a slow binding inhibitor of mEH, suggesting that the hydrolysis of 2 requires a conformational change in the enzyme-substrate complex
A unusual behaviour of N-(tert-butoxycarbonyl) and N-pivaloyl-(methylthio)anilines in metallation reaction
No full textOne-step synthesis of thioaurones
No full textA rapid, one-step preparation of 2-(arylmethylidene)-1-benzothiophen-3-ones (thioaurones) using directed alpha-metallation, ring closure and aldol-type condensation is described. The reaction leads exclusively to the Z-isomer
Metallation reactions XXVII. Metallation of (methylthio)anilines
No full textThe metallation reactions of (methylthio)anilines with organolithium reagents and with the butyllithium-potassium tert-butoxide superbasic mixture are here described. The results show that the para isomer when treated with butyllithium gave a mixture of products with no selectivity. Using tert-butyllithium or superbases we obtained the substitution of the thiomethyl hydrogen. Moreover, superbase allowed to prepare the disubstituted product with the new groups in the thiomethyl and in ortho to this group. On the other side, both or tho and meta isomers were lithiated at the thiomethyl carbon by butyllithium and the other reagents. Starting from the unalkylated amine we prepared through three successive one-pot monometallations N, N -disubstituted amines with equal or different groups and bearing an alkylthio chainas long as wanted. (C) 2001 Elsevier Science B.V. All rights reserved
Democratizzare la democrazia: istituti di partecipazione alla vita politica, economica e sociale
No full textAn Unusual Behaviour of N-(tert-Butoxycarbonyl)- and N-Pivaloyl-(methylthio)anilines in Metallation Reactions
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