555 research outputs found
Anthropology as an interdisciplinary field
No full textThe article discusses anthropology as an interdisciplinary field from the author's own research experience.AnthropologySociologySSCI0ARTICLE120-243
Stratego/XT 0.17. A Language and Toolset for Program Transformation
No full textPreprint of paper published in: Science of Computer Programming (Elsevier), 72 (1-2), 2008; doi:10.1016/j.scico.2007.11.003 Stratego/XT is a language and toolset for program transformation. The Stratego language provides rewrite rules for expressing basic transformations, programmable rewriting strategies for controlling the application of rules, concrete syntax for expressing the patterns of rules in the syntax of the object language, and dynamic rewrite rules for expressing context-sensitive transformations, thus supporting the development of transformation components at a high level of abstraction. The XT toolset offers a collection of flexible, reusable transformation components, and tools for generating such components from declarative specifications. Complete program transformation systems are composed from these components. This paper gives an overview of Stratego/XT 0.17, including a description of the Stratego language and XT transformation tools; a discussion of the implementation techniques and software engineering process; and a description of applications built with Stratego/XT.Software Computer TechnologyElectrical Engineering, Mathematics and Computer Scienc
XT-ADS sensitivity analysis
No full textThis work has been carried out in the first period (March-June 2010) In which the author Joined the Central Design Team in Mol (B) for the CDT/FASTEF EU FP7 project. Before to start with the deep characterisation foreseen during the WP2 for FASTEF (100 MW LBE cooled reactor, working in both critical and sub-critical modes), a preliminary code tuning has been carried out by adopting the XT-ADS core layout (developed in IP EUROTRANS, EU FP6 project). The tuning deals with the neutronic codes, in particular: ERANOS (deterministic) and MCNPX (Monte Carlo). The main results have been included in the two SCK-CEN calculation notes here reported. The first calculation note (ANS/RMS/TS/ARTD00CDT-02/827/10-15) highlights the main differences between the ERANOS and MCNPX models for XT-ADS. Then the ERANOS input has been modified to consider the same assumptions adopted by MCNPX. A further tuning of both models yields, as a whole, a reduction of the MCNPX-ERANOS keff difference (at BoL) from by about 2700 pcm down to 1000 pcm. The second calculation note (ANS/RMS/TS/ARTD00CDT-02/827/10-16) summarizes the XT-ADS sensitivity analysis performed by ERANOS ver. 2.1 with two different nuclear data Iibraries: JEFF3.1 and ENDF/BVI.8. The study, carried out by exploiting the basics of standard perturbation theory, points out which nuclides, which cross-section and which range of energy yield the most significant impact on the core reactivity. As in the first note, the ERANOS evaluations (performed in a reference and voided configurations) have been compared with the results obtained with the MCNFX code
Characterization and Improvement of Neural Electrode-Tissue Interface
No full textExtended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.</jats:p
IBM/XT-based automatic monitoring instrumentation system for eating behavior studies in rats
No full textAn auto-feeding system based on the IBM-XT microcomputer has been designed for use in the anti-obesity research program in the Pharmacology Department at Hoffmann-La Roche Inc. By using this system, experimental rats can be automatically fed, some which have been given anti-obesity drugs and some which have not. The system can also collect data, such as eating times and food intake, which are used for studying the rat\u27s eating behavior.
The system is designed to control thirty six cages with one experimental rat in each cage and it performs three functions:
1 ) To automatically dispense a preset quantity of food, either when the food left in the food cup falls below a minimum value or at a set interval of time.
2 ) To collect ongoing data such as eating frequency, quantity of food in the cups and quantity of food delivered.
3 ) To perform basic data analysis to show the rat\u27s eating patterns and display the data using tables and bar graphs.
The system consists of three sections: an IBM/XT microcomputer, external devices and electronic interface. The external devices of the system are constructed with the specially designed cage assembles, motor driven feeders, photo sensor pairs, position switches and electronic balances. The system is supported by electronic circuits which interface to the IBM-XT microcomputer. The electronic interfaces were designed and built by the author. The system is also equipped with a software package written in Quick Basic (a compiler BASIC) for performing experiments, testing the system and analyzing the collected data
Scaling up hepatitis B vaccination with the support of GAVI in China : lessons learned for introduction of new vaccines and for the future of hepatitis B control
No full textBackground: Hepatitis B virus (HBV) infection is a leading cause of illness and death in China. In 1992, 60% of the population had a history of HBV infection and 9.8% were chronically infected with HBV. Each year, an estimated 263,000 persons died from HBV-related hepatocellular carcinoma or cirrhosis, accounting for 37%-50% of HBV-related deaths worldwide before 1992. In 1992, the Ministry of Health introduced hepatitis B vaccine into the management system of the Expanded Programme on Immunization (EPI) as a cost-effective way to prevent HBV infection. The schedule included a timely birth dose (within 24 hours of birth, to prevent perinatal infections that are most strongly associated with long term chronic infections and adverse outcomes) and subsequent doses at one month and six months. However, this introduction into the EPI management system only meant that the Government took responsibility over administration and coverage monitoring, but not funding support: The cost of vaccination was covered out of pocket. As a result, coverage was lower in rural areas, in Western provinces (low economic status) and among females. In 2002, the Ministry of Health fully integrated free hepatitis B vaccine into EPI with funding from the Global Alliance for Vaccines and Immunization (GAVI). The GAVI China project financially supported vaccine and auto-disable syringes in Western provinces and poverty-affected counties of Central provinces (Chapter 1). As the GAVI China project was completed in 2010, we compiled all evaluation work conducted to understand how input and process lead to output and outcomes that impacted the heavy HBV associated burden in China.
Methods: We compiled data from GAVI China project areas between 2002 and 2009, reviewed cross-sectional studies conducted in 2004 and 2006 and conducted a final evaluation survey in 2010. These investigations covered input (funds invested into the project for vaccine and AD syringes), process (integration of the vaccine in EPI, increase in institutional births, introduction of auto-disable syringes for vaccination and training), output (immunization coverage for third dose and timely birth dose, use of auto-disable syringes for immunization), outcome (immunity in the population, safe injection practices) and impact (prevalence of HBV surface antigen among children included in the vaccination cohort).
Results: With respect to hepatitis B immunization, input included 27 million USD provided by the GAVI China project to funds hepatitis B vaccine between 2002 and 2007. These funds came from the international GAVI Alliance (50%) and the Government of China (50%). In addition, the Chinese government provided an additional 21.5 million USD in government co-funding of subsidies from central to provincial to health care workers in provinces between 2007 and 2009 so that the vaccine could be administered without user fees. The health system efficiently processed these resources. First, in GAVI-supported areas, the increase in the HepB3/DPT3 ratio (increased from 57% in 2002 to 94% in 2009), indicated indicating that EPI absorbed well the new vaccine. Second, institutionalized deliveries increased to reach 96% nationwide in 2009, indicating that maternal and child health services created conditions to maximize coverage of the timely birth dose. As a result, from 2002 to 2009, the national three-dose hepatitis B vaccine coverage progressed from 71% to 93% (Chapter 5) and the timely birth dose coverage progressed from 60% to 91% (Chapter 7) with a reduction of inequities between Eastern and Western areas. Both of these resulted in immunity among vaccinated cohorts (85% of anti-HBs among children 12 to 23 months of age in the national 2006 serological survey) (Chapter 2). One key factor strongly associated with being HBsAg negative is receiving timely birth dose of hepatitis B vaccine as early as possible (Chapter 4).
With respect to injection safety, input included 14 million USD of GAVI funds to supply auto-disable syringes, safety boxes and needle cutters. In 2009, auto-disable syringes and safety boxes were used in 78% and 79% facilities in GAVI supported areas of the Western areas, respectively (Chapter 6). In terms of output, sterilizable injection devices disappeared and attempts to re-use disposable injection equipment became rare (0% in the 2010 final evaluation). However, no data regarding the incidence of injection-associated infections were available to evaluate the outcome of the progress in injection safety.
With respect to social mobilization and training, 10 million USD were assigned to training between 2002 and 2009. Most of those were not directly funded by GAVI China. These funds were provided by the Government because of the leverage effect of the GAVI China project. These were used in 28,753 training workshops for health care workers that resulted in better knowledge among health care workers (In 2010, 98% of them knew that hepatitis B virus can be transmitted from mother to child) and guardians (In 2010, 89% of them knew that the first dose of hepatitis B vaccine had to be given in the first 24 hours of life). This higher level of knowledge also contributed to higher immunization coverage and safer injections.
Ultimately, the elements of the GAVI China project combined at the impact level to prevent HBV infections. The 2006 national serological survey documented these achievements and pointed to 1% prevalence of HBsAg among children under five years of age, a decrease of 90% from the 9.8% prevalence in the same age group in 1992 (Chapter 3). These infections prevented will lead to the future prevention of cirrhosis, hepatocellular carcinoma. Those should result in early deaths prevented and benefits in terms of disability-adjusted life years (DALYs). However, in 2010, it was too early to measure these longer term effects and the final impact of the project on HBsAg prevalence had not yet been quantified.
Conclusion: The introduction of hepatitis B vaccine into the national immunization programme was successful and the strategies and policy used for the GAVI China project provided a successful case study for the introduction of other new vaccines in China. The determinants of the success of the GAVI China included (1) a well documented disease burden, (2) a good collaboration between the government of China and the international GAVI Alliance that resulted in a strong national GAVI China project, (3) local production of vaccine and AD syringes, (4) solid processes for implementation and (5) leverage of additional support through national and provincial levels co-funding. Remaining challenges include (1) the persistence of an estimated 80,000 perinatal HBV infections each year in China, (2) the lack of homogeneous regulations to harmonize injection practices, (3) the absence of a scaled implementation for the national policy that recommends vaccination of health care workers, (4) the weak specificity and sensitivity of acute hepatitis B surveillance and (5) the absence of policy and plans for the management of chronic hepatitis B infection. We recommended that China (1) maintain universal hepatitis B infant vaccination, with a high priority to reach all infants, especially for those living in remote, mountain areas (2) make additional efforts to strengthen the health system and further improve hospital delivery rates to increase timely birth dose coverage and decrease perinatal HBV transmission, (3) develop clear surveillance guidelines to monitor acute hepatitis B rates (4) immunize health care workers, with an emphasis on pre-service delivery (5) collect manage sharps waste in a way that is safe for the health care workers, the community and the environment, and (6) screen pregnant women to administer adapted immuno-prophylaxis (including hepatitis B immune globulin, HBIG) for children born to those HBsAg positive. These should prepare the country for the next phase of a policy for the prevention and control of hepatitis B, which should ultimately include screening and treatment of patients with chronic infections, particularly those of older age cohorts who were born before the era of universal immunizatio
Unambiguous Recovery of Multistatic SAR Datafor Nonzero Cross Track Baseline Case
No full textA wide-swath synthetic aperture radar (SAR) image is known to be achievable by merging multistatic aliased data that is collected with an appropriate along-track displacement. However, in terms of both flexibility requirements like potentiality of both along-track and cross-track (XT) interferometry and design requirements like orbital safety, etc., a XT baseline is not only demanded but also unavoidable. In this work, a method is proposed in order to merge SAR data to recover the Doppler spectrum unambiguously for the nonzero XT baseline case. The algorithm is compared and validated by simulating an azimuth invariant multistatic SAR satellite constellation. The results are promising in terms of dealing with XT baselines.Microwave Sensing, Signals & SystemsMathematical Geodesy and Positionin
Finite difference method for detonation waves
No full textAbstractWe study an upwind finite difference scheme for detonation waves. Convergences to weak and strong solutions are discussed with some extra hypothesis. A numerical example shows that beyond these hypothesis, the situation could be more complicated and interesting
PandaX-xT: a Multi-ten-tonne Liquid Xenon Observatory at the China Jinping Underground Laboratory
No full textWe propose a major upgrade to the existing PandaX-4T experiment in the China Jinping Underground Laboratory. The new experiment, PandaX-xT, will be a multi-ten-tonne liquid xenon, ultra-low background, and general-purpose observatory. The full-scaled PandaX-xT contains a 43-tonne liquid xenon active target. Such an experiment will significantly advance our fundamental understanding of particle physics and astrophysics. The sensitivity of dark matter direct detection will be improved by nearly two orders of magnitude compared to the current best limits, approaching the so-called neutrino floor for a dark matter mass above 10 GeV/, providing a decisive test to the Weakly Interacting Massive Particle paradigm. By searching for the neutrinoless double beta decay of Xe isotope in the detector, the effective Majorana neutrino mass can be measured to a [10 -- 41] meV/ sensitivity, providing a key test to the Dirac/Majorana nature of neutrino s. Astrophysical neutrinos and other ultra-rare interactions can also be measured and searched for with an unprecedented background level, opening up new windows of discovery. Depending on the findings, PandaX-xT will seek the next stage upgrade utilizing isotopic separation on natural xenon.version as published on SCPM
Asymptotic solution of mode-iii crack in damaged softening materials
No full textIn this paper, a constitutive model of elasticity coupled with damage suggested by Lemaitre et al, [1] is used. The macroscopic stress-strain response of the model includes two stages: strain hardening and strain softening. The basic equation is derived for the anti-plane shear problem. Several lowest order asymptotic solutions are obtained, and assembled for the crack-tip fields
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