1,721,107 research outputs found
[Cardiac cell therapy: the puzzle is waiting to be solved]
No full textCell therapy has been proposed as an innovative hypothesis to treat acute myocardial infarction and heart failure. However, the mechanism by which stem cells could improve cardiac function remains unclear and many controversies have been arisen in interpretation of experimental and clinical data. Answering the five "WH questions" we discuss the process that has led to consider cell therapy as a new treatment option for myocardial tissue regeneration after ischemic damage. 1) Why should we use stem cells? The rationale derives from the disclosure that apoptosis and regeneration occur at the myocardial level and stem cells migrate from bone marrow to repopulate the damaged cardiac tissue. 2) Which are the most appropriate cells, delivery methods and therapeutic purposes? Adult stem cells can be mobilized or directly transplanted in human hearts to accomplish myocardioneogenesis, neoangiogenesis and/or paracrine effects. 3) Where should we transplant these cells? The infarct border zone seems to be the best place to home and differentiate transplanted cells hampering post-ischemic cardiac remodeling. 4) When should we perform cell therapy? Cell therapy should be performed during or after an acute myocardial infarction: best setting and timing still need to be precisely addressed. 5) Who might be the suitable patient? Further multicenter randomized trials with adequate patient selection are needed to answer this crucial question
Genetic education and the challenge of genomic medicine: development of core competences to support preparation of health professionals in Europe
No full textEuroGentest patient information leaflets: a free resource available in over 20 languages
No full textAn assessment of written patient information provided at the genetic clinic and relating to genetic testing in seven European countries
No full textGenetic testing and counselling in Europe: health professionals current educational provision, needs assessment and potential strategies for the future
No full textOrbital angular momentum modes from vertical-cavity surface-emitting lasers
Full text linkA computationally efficient theoretical approach is used to assess the performance of novel devices with directly emitting optical vortex modes
Genotype/phenotype correlations of males affected by Simpson-Golabi-Behmel syndrome with GPC3 gene mutations: patient report and review of the literature.
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Patenting and licensing in genetic testing: recommendations of the European Society of Human Genetics.
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