22,489 research outputs found
Protecting Animals 36: Author Witi Ihimaera
No full textIn this very special episode of Knowing Animals I am joined by beloved New Zealand author Witi Ihimaera. Witi has written many books featuring nonhuman animals. He offers us a non-colonial lens through which to think about the human/nonhuman relationship
Ductile damage assessment of Ti6Al4V, 17-4PH and AlSi10Mg for additive manufacturing
No full textA great research effort has been spent during the latest years in the characterization of additive manufacturing (AM) alloys, mostly focused on the analysis of microstructure and on the assessment of mechanical strength, especially under high cycle fatigue loads. Post-process treatments have been also investigated, as methods to further improve the AM materials performance. On the contrary, still fewer data are available on AM materials ultimate static strength. The present paper is intended to present a comprehensive experimental and numerical static characterization of Ti6Al4V, 17-4PH, and AlSi10Mg alloys processed via selective laser melting. A dedicated set of specimen geometries was devised to induce desired multiaxial stress state, and experiments were carried out both on as built and machined AM samples. The results were employed to identify the constitutive behavior of the materials and to calibrate four different ductile damage models. The failure prediction capabilities of the tuned models were thoroughly analyzed and discussed. The overall mechanical properties and the ductility of the investigated alloys were estimated based on the experimental results and on the information provided by the tuned models. Additionally, a comparison with data collected on the corresponding wrought materials, performing the same experiments, was carried out. The results showed a limited reduction of yield and failure strength and a significant reduction in the ductility of AM materials with respect to their wrought counterparts. Moreover, for the less ductile alloys, a weaker dependence of the strain to fracture from the stress state was observed
Are concerns about DSM-5 ADHD criteria supported by empirical evidence?
No full textThomas and colleagues are worried about the recent change in the maximum age of symptom onset in the diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD) from 7 years in the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) to 12 years in DSM-5.1 2 3 They think that this change may increase “the risk of confusing ADHD with normal developmental processes, such as pubertal restlessness and distractibility.” Although it is a legitimate concern, I am not aware of any empirical evidence to support it.Indeed, a study of 2232 British children showed that extending the age of onset from 7 to 12 years increases the prevalence of ADHD by only 0.1%.4 If this change had led to non-pathological behaviours being diagnosed as ADHD, a bigger increase in prevalence would be expected. Children diagnosed with ADHD before and after 7 years also had similar clinical profiles and ADHD risk factors.4This recent change in the age of onset criterion was aimed at reducing false negative diagnoses in adults. Only half of adults assessed for ADHD recall onset of symptoms before age 7; 95% report onset before age 12.5 The UK study suggested that adults who retrospectively reported onset of ADHD between 7 and 12 years probably had symptoms before 7 years.4 Therefore, keeping the age of onset criterion at 7 years would contribute to underdiagnosis in a substantial number of adults.Finally, to avoid labelling transitory processes as ADHD, DSM-5 criteria specify that “symptoms have persisted for at least 6 months to a degree that is inconsistent with developmental level.” DSM-5 criteria are therefore unlikely to increase the risk of misdiagnosing pubertal restlessness and distractibility as ADHD. However, as Thomas and colleagues note,1 pubertal restlessness and distractibility should be considered in the differential diagnosis of ADHD.<br/
Development of chimpanzee adenoviruses as vaccine vectors: challenges and successes emerging from clinical trials.
No full textReplication-defective chimpanzee adenovirus vectors are emerging as a promising new class of genetic vaccine carriers. Chimpanzee adenovirus vectors have now reached the clinical stage and appear to be endowed with all the properties needed for human vaccine development, including high quality and magnitude of the immune response induced against the encoded antigens, good safety and ease of manufacturing on a large-scale basis. Here the authors review the recent findings of this novel class of adenovirus vectors and compare their properties to other clinical stage vaccine vectors derived from poxvirus, alphavirus and human adenovirus
I Think I Am Philip K. Dick
No full textFor years, noted writer Laurence A. Rickels often found himself compared to novelist Philip K. Dickthough in fact Rickels had never read any of the science fiction writers work. When he finally read his first Philip K. Dick novel, while researching for his recent book The Devil Notebooks , it prompted a prolonged immersion in Dicks writing as well as a recognition of Rickelss own long-documented intellectual pursuits. The result of this engagement is I Think I Am: Philip K. Dick , a profound thought experiment that charts the wide relevance of the pulp sci-fi author and paranoid visionary. I Think I Am: Philip K. Dick explores the science fiction authors meditations on psychic reality and psychosis, Christian mysticism, Eastern religion, and modern spiritualism. Covering all of Dicks science fiction, Rickels corrects the lack of scholarly interest in the legendary Californian author and, ultimately, makes a compelling case for the philosophical and psychoanalytic significance of Philip K. Dicks popular and influential science fiction.Intro -- Contents -- Introjection -- Part I -- Endopsychic Allegories -- Schreber Guardian -- Belief System Surveillance -- Part II -- Deeper Problems -- Veil of Tears -- Go West -- Dick Manfred -- Timing -- Glimmung -- Part III -- Spiritualism Analogy -- Imitating the Dead -- Indexical Layer -- Ilse -- Hammers and Things -- Crucifictions -- Over There -- Martyrology -- Can't Live, Can't Live -- Lola -- Umwelt, Mitwelt, and Eigenwelt -- Outer Race -- The German Introject -- Part IV -- Materialism, Idealism, and Cybernetics -- Startling Stories -- A Couple of Years -- Android Empathy -- Homunculus and Robot -- ALL OF YOU ARE DEAD. I AM ALIVE. -- Go with the Flow -- Part V -- Room for Thought -- Caduceus -- Jump -- Still -- A Wake -- Spätwerk -- Let the Dead Be -- Play Bally -- Das Hund -- Notes -- BibliographyFor years, noted writer Laurence A. Rickels often found himself compared to novelist Philip K. Dickthough in fact Rickels had never read any of the science fiction writers work. When he finally read his first Philip K. Dick novel, while researching for his recent book The Devil Notebooks , it prompted a prolonged immersion in Dicks writing as well as a recognition of Rickelss own long-documented intellectual pursuits. The result of this engagement is I Think I Am: Philip K. Dick , a profound thought experiment that charts the wide relevance of the pulp sci-fi author and paranoid visionary. I Think I Am: Philip K. Dick explores the science fiction authors meditations on psychic reality and psychosis, Christian mysticism, Eastern religion, and modern spiritualism. Covering all of Dicks science fiction, Rickels corrects the lack of scholarly interest in the legendary Californian author and, ultimately, makes a compelling case for the philosophical and psychoanalytic significance of Philip K. Dicks popular and influential science fiction.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
MSJ900971_supplemental_material – Supplemental material for Ongoing microstructural changes in the cervical cord underpin disability progression in early primary progressive multiple sclerosis
No full textSupplemental material, MSJ900971_supplemental_material for Ongoing microstructural changes in the cervical cord underpin disability progression in early primary progressive multiple sclerosis by Rosa Cortese, Carmen Tur, Ferran Prados, Torben Schneider, Baris Kanber, Marcello Moccia, Claudia AM Gandini Wheeler-Kingshott, Alan J Thompson, Frederik Barkhof and Olga Ciccarelli in Multiple Sclerosis Journal</p
Liftings for noncomplete probability spaces
No full textThe current state of knowledge concerning liftings for noncomplete probability spaces is discussed. This is a somewhat expanded version of the author's talk given at the 1991 Summer Conference on General Topology and Applications in Honor of Mary Ellen Rudin and Her Work.PT: S; CR: BURKE MR, IN PRESS P AM MATH S BURKE MR, 1991, ISRAEL J MATH, V73, P33 BURKE MR, 1992, ISRAEL J MATH, V79, P289 CARLSON T, THEOREM LIFTING CHRISTENSEN JPR, 1974, TOPOLOGY BOREL STRUC FREMLIN DH, 1989, HDB BOOLEAN ALGEBRAS, P877 INOESCUTULCEA A, 1966, 5TH P BERK S MATH ST, V2 IONESCUTULCEA A, 1967, CONTRIBUTIONS PROB 1, P63 IONESCUTULCEA A, 1969, TOPICS THEORY LIFTIN JECH TJ, 1978, SET THEORY JOHNSON RA, 1980, P AM MATH SOC, V80, P234 JUST W, IN PRESS T AM MATH S KUPKA J, 1983, INDIANA U MATH J, V32, P717 LOSERT V, 1983, LNM, V1080, P95 MAHARAM D, 1958, P AM MATH SOC, V9, P987 SHELAH S, 1983, ISRAEL J MATH, V45, P90 TALAGRAND M, 1982, P AM MATH SOC, V84, P379 VONNEUMANN J, 1931, CRELLES J MATH, V165, P109; NR: 18; TC: 0; J9: ANN N Y ACAD SCI; PG: 4; GA: BZ86BSource type: Electronic(1
Cortical gamma-synchrony measured with magnetoencephalography is a marker of clinical status and predicts clinical outcome in stroke survivors.
No full textBackground: The outcome of stroke survivors is difficult to anticipate. While the extent of the anatomical brain lesion is only poorly correlated with the prognosis, functional measures of cortical synchrony, brain networks and cortical plasticity seem to be good predictors of clinical recovery. In this field, gamma (>30 Hz) cortical synchrony is an ideal marker of brain function, as it plays a crucial role for the integration of information, it is an indirect marker of Glutamate/GABA balance and it directly estimates the reserve of parvalbulin-positive neurons, key players in synaptic plasticity. In this study we measured gamma synchronization driven by external auditory stimulation with magnetoencephalography and tested whether it was predictive of the clinical outcome in stroke survivors undergoing intensive rehabilitation in a tertiary rehabilitation center. Material and methods: Eleven stroke survivors undergoing intensive rehabilitation were prospectively recruited. Gamma synchrony was measured non-invasively within one month from stroke onset with magnetoencephalography, both at rest and during entrainment with external 40 Hz amplitude modulated binaural sounds. Lesion location and volume were quantitatively assessed through a high-resolution anatomical MRI. Barthel index (BI) and Functional Independence Measure (FIM) scales were measured at the beginning and at the end of the admission to the rehabilitation unit. Results: The spatial distribution of cortical gamma synchrony was altered, and the physiological right hemispheric dominance observed in healthy controls was attenuated or lost. Entrained gamma synchronization (but not resting state gamma synchrony) showed a very high correlation with the clinical status at both admission and discharge (both BI and FIM). Neither clinical status nor gamma synchrony showed a correlation with lesion volume. Conclusions: Cortical gamma synchrony related to auditory entrainment can be reliably measured in stroke patients. Gamma synchrony is strongly associated with the clinical outcome of stroke survivors undergoing rehabilitation
Role of Macrophages in Internalization and Early Clearance of Pseudomonas Aeruginosa from the Mouse Lung
No full textThis study aimed to evaluate the role of alveolar macrophages (AMs) in the internalisation and early clearance of Pseudomonas aeruginosa in the lung. AMs were depleted by intranasal administration of liposome-encapsulated clodronate disodium. At 24 h following the instillation of liposomes, a sublethal dose of P. aeruginosa (1 X 104 cfu) was inoculated intratracheally. Lung tissue was then evaluated for survival, viable bacteria and for histopathology 4 and 24 h post-infection. AM depletion of 90% did not affect the survival rate of infected mice but the clearance of P. aeruginosa was reduced at 24 h (P<0.05). While at 4 h AM-depleted and control mice showed similar level of PMN recruitment in the distal lung, 24 h post-infection tickening of interstitial spaces was more marked in AM-depleted mice. To evaluate the integrity of the epithelial barrier, the presence of bacteria in the spleen was assessed at 4 and 24 h. AM-depleted mice presented equal numbers of colonies as compared to control mice. At 4 h post-infection, the total and internalized numbers of bacteria were not different from the control group following a high-dose bacterial challenge (1 X 107 cfu). Our study show that AMs do not influence bacterial internalisation by airway epithelial cells.Read Complete Article at ijSciences: V220131239
The AM Canum Venaticorum binary SDSS J173047.59+554518.5
No full textThe AM Canum Venaticorum (AM CVn) binaries are a rare group of hydrogen-deficient, ultrashort period, mass-transferring white dwarf binaries and are possible progenitors of Type Ia supernovae. We present time-resolved spectroscopy of the recently discovered AM CVn binary SDSS J173047.59+554518.5. The average spectrum shows strong double-peaked helium emission lines, as well as a variety of metal lines, including neon; this is the second detection of neon in an AM CVn binary, after the much brighter system GP Com. We detect no calcium in the accretion disc, a puzzling feature that has been noted in many of the longer period AM CVn binaries. We measure an orbital period, from the radial velocities of the emission lines, of 35.2 ± 0.2 min, confirming the ultracompact binary nature of the system. The emission lines seen in SDSS J1730 are very narrow, although double-peaked, implying a low-inclination, face-on accretion disc; using the measured velocities of the line peaks, we estimate i ≤ 11°. This low inclination makes SDSS J1730 an excellent system for the identification of emission lines
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