1,721,003 research outputs found
Sensitization to Formaldehyde in Northeastern Italy, 1996 to 2012
No full textBackground Formaldehyde is a widely used organic compound, used in several applications (hard thermoset resins, adhesives, disinfectants, tissue fixatives, etc), in its free form or released by formaldehyde releaser products. Its use is under control due to its toxic, carcinogenic, and allergenic properties. Objective The aim of this study was to investigate the frequency of formaldehyde sensitization, time trend, and correlation to occupations. Methods This study is a cross-sectional study on a population of 23,774 patients tested from 1996 to 2012 in Northeastern Italy. Results Frequency of sensitization was 3.3%, without any significant time trend. Hands (39.8% overall) and face (25.6% females, 15.5% males) were mainly involved. We found a trend toward decrease by age in females (3.11% in first quintile [14-26 years], 2.29% in fifth quintile [59-97 years], P < 0.01). On a logistic regression analysis (control group: white-collar workers), we found associations in health care (odds ratio [OR], 1.37; 95% confidence interval [CI], 1.04-1.81), wood (OR, 2.14; 95% CI, 1.30-3.51), and textile (OR, 1.79; 95% CI, 1.14-2.79) sectors and professional drivers (OR, 1.94; 95% CI, 1.05-3.60). We found a high rate of cosensitization to formaldehyde in patients with positive patch test reactions to quaternium-15 (OR, 18.7; 95% CI, 12.6-27.7). Conclusions Sensitization to formaldehyde is relevant in our population, especially in the health care sector, wood and textile industries, and professional drivers. No significant time trend was found
Nickel, chromium and cobalt sensitization in a patch test population in north-eastern Italy (1996-2010).
No full textBackground. Sensitization to nickel, cobalt and chromium is frequent in patch test
populations. The prevalence is affected by geographical and socio-cultural factors.
Objectives. To investigate the temporal trend of nickel, cobalt and chromium contact
sensitization between 1996 and 2010 in north-eastern Italy.
Patients/methods. Nineteen thousand and eighty-eight patients (67.2% women and
32.8%men)withsuspectedallergic dermatitisunderwentpatchtestingwith theEuropean
baseline series. The associations between nickel, cobalt and chromium sensitization and
patient age (in quintiles) and year of patch testing were investigated by means of
multivariate logistic regression analysis.
Results. The prevalence of nickel sensitization decreased significantly among younger
women (≤26 years), from 38.3% (1996–1998) to 31.9% (2002–2004), 28.3%
(2005–2007) and 29.0% (2008–2010), whereas an increase was observed in
the 36–45-year and 46–58-year age groups. The overall prevalence of chromium
sensitization dropped from 10.2% (1996–1998) to 4.6% (2008–2010) among women,
and from 11.3% (1996–1998) to 5.9% (2008–2010) among men. The prevalence of
cobalt sensitization increasedamongyoungermen(≤26 years), from2.7%(1996–1998)
to 7.3% (1999–2001), 9.6% (2002–2004), and 6.6% (2005–2007).
Conclusions. Our study showed a decreasing trend of nickel sensitization (only among
younger women) and of chromium sensitization in both sexes
Effectiveness of European Regulation on Euxyl K400 Sensitization in Northeastern Italy From 1996 to 2012 and Occupation
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Sensibilizzazione e dermatiti da contatto nei lavoratori della sanità: dati di prevalenza nel nord est Italia.
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