1,721,558 research outputs found
Novel Therapeutic Approaches and Targets for Treatment of Vulvar Lichen Sclerosus
No full textBACKGROUND: Vulvar Lichen Sclerosus (VLS) is a chronic inflammatory disease with a huge impact on a person's quality of life. A correct therapy is required for relieving symptoms, reversing signs and preventing further anatomical changes. OBJECTIVE: The main objective of the present paper is to provide suggestions for the best treatment approach, based on the available evidence. Treatment strategies are divided on the basis of the treatment phase, distinguishing options for initial, acute or attack treatment and those for long-term, maintenance treatment. METHODS: An electronic search was performed using the National Library of Medicine PubMed database. All the studies evaluating treatment of vulvar lichen sclerosus published in the English literature were analyzed, including controlled studies, case series, guidelines and reviews. RESULTS: Current evidence identifies ultra-potent and potent corticosteroids, administered for 12 weeks, as the first-line recommended treatment for active VLS. Topical calcineurin inhibitors, tacrolimus and pimecrolimus, are effective and safe alternatives. Long-term maintenance strategies aimed at preventing recurrences are required, after the initial treatment phase. Maintenance treatment mostly consists in topical corticosteroids, administered i) on an "as needed" basis ("reactive" scheme), ii) on a continuative regimen, iii) on a low-dose, intermittent regimen ("proactive" scheme). Further investigations are needed for better defining the placement of other options within the VLS therapeutic algorithm, including retinoids, physical and systemic treatments. CONCLUSION: The available evidence provides useful indications for the management of VLS. Both the identification of new therapeutic targets and the optimization of the available options represent the main objectives of future research
Crohn's disease of the vulva: A case report
No full textA rare case of vulvar Crohn's disease occurred in a 43-year-old woman who presented with a monolateral plaque on the vulva with a granulomatous histologic pattern. The problem of distinguishing Crohn's granuloma from other granulomatous lesions is underlined
Allergic contact dermatitis from ophthalmic products: can pre-treatment with sodium lauryl sulfate increase patch test sensitivity?
No full textIn patients suspected of allergic contact dermatitis because of topical ophthalmic medicaments, patch tests performed with patients' own products are often negative. The irritant anionic surfactant sodium lauryl sulfate (SLS) may alter the stratum corneum and increase antigen penetration. Pre-treatment of the skin with SLS 0.5% for 24 h was performed in the sites of patch tests with patients' own products in 15 selected patients. In patients previously negative to their own products tested with conventional patch tests, SLS pre-treatment showed 6 new relevant positive reactions and induced a stronger positive reaction in 1 patient. SLS pre-treatment could be proposed as an alternative promising method, which may increase sensitivity of patch tests with patients' own products
Ecologia delle Infrastrutture Viarie a tutela dell’ambiente: concetti e criteri per una ricerca allargata alle discipline trasportistiche // Ecology of Transportation Infrastructure to protect the environment: concepts and criteria for a research extended to the transportation studies
Full text linkL’articolo prende spunto dalla letteratura scientifica in materia di Road Ecology e Railway Ecology per riunire i concetti fondativi e i criteri applicativi sotto un’unica definizione, quella della Ecologia delle Infrastrutture Viarie. Il comun denominatore è l’impatto negativo che le infrastrutture per i trasporti (sia su asfalto che su ferro) esercitano sugli ecosistemi naturali, generando perdita e/o frammentazione di habitat per le specie animali e vegetali. Sebbene ancora poco consolidati in ambito trasportistico, gli studi in materia di Ecologia delle Infrastrutture appaiono dirimenti quando si deve affrontare la norma sulla valutazione ambientale strategica di una infrastruttura per i trasporti alla scala paesaggistica. A tal fine si propongono criteri di valutazione per meglio ottemperare alla norma e si presentano le principali misure attuative con l’obiettivo di sensibilizzare i ricercatori e gli operatori di ambito trasportistico sulla necessità di introdurre l’Ecologia delle Infrastrutture Viarie nelle pratiche di studio, progettazione, costruzione, manutenzione e valutazione dei manufatti ferroviari quale garanzia di tutela ambientale
Trasporto Pubblico Locale
No full textSintesi degli effetti dei cambiamenti climatici sulle infrastrutture del trasporto pubblico local
I concetti di road ecology e railway ecology a fondamento dell’ecologia delle infrastrutture viarie
No full textStudio sui concetti di road ecology e railway ecology a fondamento dell’ecologia delle infrastrutture viarie, nell'ambito della normativa ambientale italiana sulle opere infrastruttural
The Wild Market of Natural Cosmetics of Obscure Safety
No full textDespite popularity and tradition, there is still chaos out of reach of affordable toxicological testing and also out of reach of regulatory control. However, today the concept of “no safety problem” of natural products has reached a level of religious belief among people. Therefore, the widespread “natural product” abolition is not a possible solution to reduce the adverse reactions from phytoextract
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