1,721,287 research outputs found
Metodo per la preparazione di forme farmaceutiche orali a rilascio prolungato contenenti sostanze attive a solubilità dipendente dal valore di pH
No full text
Antiviral pharmaceutical compositions for vaginal administration
No full textBiocompatible sustained-release vaginal antiviral compositions in form of effervescent tablets, bioadhesive tablets, bi-layered tablets, bioadhesive washes, are described
Formulazioni farmaceutiche a rilascio modificato, con elevata biodisponibilità, contenenti principi attivi ad attività antibiotica
No full textVengono descritte formulazioni farmaceutiche in grado di aumentare la biodisponibilità di sostanze ad attività antibiotic
Evaluation of the dissolution characteristics of a gastroprotected dosage form in controlled storage conditions
No full textComposizioni farmaceutiche, a rilascio modificato, contenente principi attivi ad attività calcio antagonista
No full textGeomatrix technology. Delivery systems for the controlled release of drugs
No full textIntroduction 7
2. Drug delivery systems 11
2.1 Therapeutic advantages
2.2 Drug bioavailability
2.3 Conventional drug formats
2.4 Drug delivery systems
3. Oral drug delivery systems 17
3.1 Coated systems
3.2 Matrix systems
3.3 Hydrophilic, swellable, gellable or erodible polymers
3.4 Polymer dissolution rate
3.5 Molecule diffusion and transport in polymer systems
3.6 Drug release rate from a polymer matrix
3.7 Conventional hydrophilic, swellable, gellable matrices
3.8 In-vitro dissolution test and in-vitro/in-vivo correlation
4. GEOMATRIX technology 31
4.1 Drug release control mechanisms
4.2 Active core plus barriers
4.3 Study of the action mechanisms of barriers
4.4 Modulation of the drug release
profile by the GEOMATRIX system
4.5 Swellable, gellable barriers
4.6 Erodible barriers
4.7 Manufacturing
4.8 Materials used
4.9 Development, scale-up, quality control,
production and certification
Versatility of the modular GEOMATRIX system 55
5.1 Examples of GEOMATRIX systems for extended
release of drugs at a constant rate
5.2 Drug delivery systems for the controlled release
of partially soluble drugs
5.3 Drug delivery systems for the delayed
release of drugs
5.4 Drug delivery systems for the bi-phasic
release of drugs
5.5 Drug delivery systems for the release of two
or more drugs at different rates (binary release)
5.6 Drug delivery systems for the pulsed
release of drugs
6 Conclusions 81
7 References 8
A flexible technology for the linear, pulsatile and delayed release of drugs, allowing for easy accomodation of difficult in vitro targets
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Therapeutic system for the controlled release of active ingredients
No full textA system designed to release one or more active substances in different, previously programmable modes, is described. The system is constituted by a tablet in three layers, two of which (the outer layers) vehicularise the active ingredient(s), whilst the third (the central layer) is constituted of a polymeric barrier which does not contain active substance and has the appropriate characteristics of erodibility or gelation. The tablet is completely coated with a film of polymeric material insoluble in water and/or in aqueous fluids, on which one or more incisions delimiting an area of exactly calculated geometric shape and size, have been made through the use of a laser beam of appropriate power and intensity. The removal of the film inside the incision(s) allows the release of the active ingredient(s) into aqueous fluid in predetermined amounts and umes. The procedure for the production of the aforementioned pharmaceutical form is also described
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