171,198 research outputs found
Comment on 'The latency period of mesothelioma among a cohort of British asbestos workers (1978-2005)': methodological problems with case-only survival analysis.
No full textDesign and performance evaluation of a waste-to-energy plant integrated with a combined cycle
No full text
Design and Performance evaluation of a Waste-to-Energy Plant integrated with a Combined Cycle
No full textIl voto «europeista» degli italiani in Francia
No full textIntroduzione Questo contributo si propone di analizzare l’andamento del voto dei residenti italiani in Francia nel decennio tra il 2008 e il 2018 per verificare se, rispetto a quanto emerso in una precedente analisi del 2012 sul voto nella ripartizione Europa, vi siano stati cambiamenti significativi (Consonni, 2012). In particolare, tale studio aveva evidenziato l’attivismo delle strutture associative in veste di comitati elettorali, l’interesse crescente dei partiti a inserire nelle liste c..
Enhanced objective Bayesian testing for the equality of two proportions
No full textWe develop a new class of prior distributions for Bayesian comparison of nested models, which we call intrinsic moment priors, by combining the well-established notion of intrinsic prior with the recently introduced idea of non-local priors, and in particular of moment priors. Specifically, we aim at testing the equality of two proportions, based on independent samples, and thus focus on discrete data models. Given two nested models, each equipped with a default prior, we first construct a moment prior under the larger model. In this way, the asymptotic learning behavior of the Bayes factor is strengthened, relative to currently used local priors, when the smaller model holds; remarkably, this effect is already apparent for moderate sample sizes. On the other hand, the symptotic learning behavior of the Bayes factor when the larger model holds is unchanged. However, without appropriate tuning, a moment prior does not provide enough evidence for the larger model when the sample size is small and the data only moderately support the smaller one. For this reason, we apply to the moment prior an intrinsic prior procedure, which amounts to pulling the moment prior towards the subspace specified by the smaller model; we provide general guidelines for determining the training sample size necessary to implement this step. Thus, by joining the virtues of moment and intrinsic priors, we obtain an enhanced objective Bayesian testing procedure: i) our evidence for small samples is broadly comparable to that given by current objective methods; ii) we achieve a superior learning performance as the sample size increases (when the smaller model holds). We first illustrate our methodology in a running Bernoulli example, where we test a sharp null hypothesis, then we implement our procedure to test the equality of two proportions. A detailed analysis of the properties of our method, including a comparison with standard intrinsic priors, is presented together with an application to a collection of real-world 2 by 2 tables involving a sensitivity analysis and a crossvalidation study.<br/
The CC-NB-LRR-Type Rdg2a resistance gene confers immunity to the seed-borne barley leaf stripe pathogen in the absence of hypersensitive cell death
No full textBACKGROUND: Leaf stripe disease on barley (Hordeum vulgare) is caused by the seed-transmitted hemi-biotrophic fungus Pyrenophora graminea. Race-specific resistance to leaf stripe is controlled by two known Rdg (Resistance to Drechslera graminea) genes: the H. spontaneum-derived Rdg1a and Rdg2a, identified in H. vulgare. The aim of the present work was to isolate the Rdg2a leaf stripe resistance gene, to characterize the Rdg2a locus organization and evolution and to elucidate the histological bases of Rdg2a-based leaf stripe resistance. PRINCIPLE FINDINGS: We describe here the positional cloning and functional characterization of the leaf stripe resistance gene Rdg2a. At the Rdg2a locus, three sequence-related coiled-coil, nucleotide-binding site, and leucine-rich repeat (CC-NB-LRR) encoding genes were identified. Sequence comparisons suggested that paralogs of this resistance locus evolved through recent gene duplication, and were subjected to frequent sequence exchange. Transformation of the leaf stripe susceptible cv. Golden Promise with two Rdg2a-candidates under the control of their native 5′ regulatory sequences identified a member of the CC-NB-LRR gene family that conferred resistance against the Dg2 leaf stripe isolate, against which the Rdg2a-gene is effective. Histological analysis demonstrated that Rdg2a-mediated leaf stripe resistance involves autofluorescing cells and prevents pathogen colonization in the embryos without any detectable hypersensitive cell death response, supporting a cell wall reinforcement-based resistance mechanism. CONCLUSIONS: This work reports about the cloning of a resistance gene effective against a seed borne disease. We observed that Rdg2a was subjected to diversifying selection which is consistent with a model in which the R gene co-evolves with a pathogen effector(s) gene. We propose that inducible responses giving rise to physical and chemical barriers to infection in the cell walls and intercellular spaces of the barley embryo tissues represent mechanisms by which the CC-NB-LRR-encoding Rdg2a gene mediates resistance to leaf stripe in the absence of hypersensitive cell death.Davide Bulgarelli, Chiara Biselli, Nicholas C. Collins, Gabriella Consonni, Antonio M. Stanca, Paul Schulze-Lefert and Giampiero Val
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