1,219 research outputs found

    An interview with Alfredo Falcone and Lisa Salvatore: RECOURSE and trifluridine/tipiracil in metastatic colorectal cancer

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    Professor Alfredo Falcone and Dr Lisa Salvatore speak to Roshaine Gunawardana, Managing Commissioning Editor: Professor Alfredo Falcone is the Director of the Department of Oncology and the Specialization School at the University Hospital of Pisa, Italy. He trained in Pisa and Genoa, Italy, and has held major positions in Italian oncology since 2000. He currently has more than 300 publications, including papers in peer-reviewed international and national journals, book chapters, and more than 600 abstracts of presentations to international and national conferences. The majority of his papers regard clinical and translational research, with a particular focus on metastatic colorectal cancer. Dr Lisa Salvatore is a medical oncologist in the Department of Translational Research and New Technologies in Medicine and Surgery at the University of Pisa. She has been an author on about 40 publications in major peer-reviewed publications and has made numerous presentations in national and international conferences. Her main interest is focused on clinical and translational research in metastatic colorectal cancer

    Performative Architecture: New Semantic for New Shapes?

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    Two innovations have more deeply changed the building process: the operational continuity of the design and construction phases and the software allowing not only the representation but also the autonomous creation of complex shapes never before thought, just because they could not be represented. This last innovation introduce to a “Performative Architecture” that addresses to emerge a new kind of architecture. Building performances (structural, environmental, energetic) are guiding design principles, adopting new building performance-based priorities for the design of cities, buildings and landscape. This emerging architecture places broadly defined performance above form making, It utilises digital technologies of quantitative and qualitative performance-based simulation to offer a comprehensive approach to the design of the build environment. Some aspects of “Performative Architecturei theories are critically examined and we report two experiments made using these procedures. The results try to give a contribution to detect some misunderstandings in relation to recent building projects shown

    “Background of a polemic over the executive title” of Salvatore Satta: fifty years later…

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    Traducción al castellano de un provocador escrito de Salvatore Satta publicado en 1967 en la Rivista trimestrale di diritto e procedura civile, en el que el insigne autor reacciona y toma posición sobre la críticas dirigidas en contra del libro de Ferdinando Mazzarella sobre el título ejecutivo.Spanish translation of a provocative work by Salvatore Satta published in 1967 in the Rivista trimestrale di diritto e procedura civile, in which the famous author reacts and takes a position on the criticisms directed against Ferdinando Mazzarella's book on the executive title

    Involucro, crocevia di segni, mode e tecnologia

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    The word “envelope, involucro” has, in Italian, two meanings. First, it denotes the physical object that envelops something else of which it hides and substitutes the appearance. The second meaning, metaphorical, identifies a set of concepts and thoughts. In architecture, the envelope expresses both meanings, gives physical body to the first, and, in the same time reveals intentions and cultural premises of the architect. Specially innovative are the works of the so called top few architects. Their projects present three main reasons of interest, if observed from a designer’s point of view. The first: the procedure of generating shapes, tightly linked with the representation possibilities and then with the digital tools. The second: the growing importance of the contribution the envelope gives to the energetic-environmental balance of the whole building, also with an autonomous production of energy. The third: the growth of the communication function. From the latter point of view the envelope shows a marked trend to transform itself from a simple support of various “communication machines” to a direct and autonomous “communication machine” (a paradigmatic example is the Kunsthaus in Graz). Well established functions and new ones are realised with new technologies and well established ones. And sometimes all the four undergo fashionable bias
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