1,721,028 research outputs found
Correlazione tra presenza di IgA anti CagA e patologia ulcerosa in pazienti infettati da Helicobacter pylori
No full textHIV-associated nephropathy, that is to say how HIV can play a direct role in the disorders of an organ system
No full textGli effetti di Tat sui podociti (iperplasia, attivazione del citoscheletro, redistribuzione della nefrina) costituiscono meccanismi potenziali del danno renale nei pazienti HIV-positivi
No full textESCHERICHIA COLI PORIN INDUCES PROINFLAMMATORY ALTERATIOS IN RENAL TUBULAR EPITHELIAL CELLS
No full text“Infections and atherosclerosis-focus on periodontal pathogens, Chlamydia pneuminiae and enterovirus”
No full textDistinct pathogenic effects of group B coxsackieviruses on human glomerular and tubular kidney cells
No full textInfezione da coxsackievirus B e patologie autoimmuni: possibile ruolo della replicazione persistente di questi agenti virali in cellule endoteliali microvascolari
No full textRuolo dell’interazione tra HIV-1 e cellule renali nello sviluppo della nefropatia HIV-associata
No full text
PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs
Full text linkNeuroblastoma (NB) is the most common and aggressive pediatric cancer, characterized by a remarkable phenotypic diversity and high malignancy. The heterogeneous clinical behavior, ranging from spontaneous remission to fatal metastatic disease, is attributable to NB biology and genetics. Despite major advances in therapies, NB is still associated with a high morbidity and mortality. Thus, novel diagnostic, prognostic, and therapeutic approaches are required, mainly to improve treatment outcomes of high-risk NB patients. Among neuroepithelial cancers, NB is the most studied tumor as far as PPAR ligands are concerned. PPAR ligands are endowed with antitumoral effects, mainly acting on cancer stem cells, and constitute a possible add-on therapy to antiblastic drugs, in particular for NB with unfavourable prognosis. While discussing clinical background, this review will provide a synopsis of the major studies about PPAR expression in NB, focusing on the potential beneficial effects of hypoglycemic drugs, thiazolidinediones and metformin, to reduce the occurrence of relapses as well as tumor regrowth in NB patients
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