1,721,073 research outputs found
EXPERT REPORT ON THE QUALITY ASSURANCE OF THE PRODUCTION OF MEDICINES FROM BOVINE ORIGIN INCLUDING A RISK ASSESSMENT
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SISTEMA PER LA RILEVAZIONE E LA QUANTIFICAZIONE DI DNA ESOGENO DI ORIGINE ANIMALE IN FARINE ALIMENTARI DESTINATE AL SETTORE ZOOTECNICO
No full textnumero domanda: M12004A000991
data deposito: 18 maggio 200
The doppel gene biology: a scientific journey from brain to testis, and return.
No full textDoppel is a newly recognized prion-like molecule encoded by a novel gene locus, PRND,
located on the same chromosomal region of the prion (PRNP) coding gene. Doppel was considered
a paralogue and the first member of the prion-gene family, possibly originated through an ancestral
gene duplication event. Prion and doppel have different expression patterns, suggesting that the gene
products exhibit different biological functions. Actually, doppel is not involved in the aetiology of the
Transmissible Spongiform Encephalopathies (TSEs) or “prion diseases” and is highly expressed only
within the testicular tissue, suggesting an important physiological role in the process of spermatogenesis.
The restricted spatial and temporal expression profile of doppel has suggested its investigation within
particular pathological contexts, such as cancers, showing that it might represent a novel and attractive
diagnostic molecular marker and that might provide insights into the regulatory pathways of tumor-cell
transformation
Autophagy and ionizing radiation in tumors: the “survive or not survive” dilemma
No full textAutophagy is a so-called ‘self-eating’ system responsible for degrading long-lived proteins and cytoplasmic organelles, whose products are recycled to maintain cellular homeostasis. This ability makes autophagy a good candidate for a survival mechanism in response to several stresses, including the tumor cell transformation. In particular, recent studies suggested that autophagy functions as a pro-death mechanism within different tumor contexts. It is however widely reported that autophagy represents both a survival mechanism or contributes directly to cell death fate. This interplay of the autophagy functions has been observed in many types of cancersand, in some cases, autophagy has been demonstrated to both promote and inhibit antitumor drug resistance. From a therapeutical point of view, the effects of the modulation of the tumor cell autophagic status, in responce to ionizing radiations, are presently of particular relevance in oncology. Accordingly, this review also provide a perspective view on future works for exploring the modulation of autophagic indices in tumor cells as a novel molecular-based adjuvant strategy, in order to improve radiotherapy and chemotherapy effects in cancer patients
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