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Antibacterial spectra of drugs used for chemotherapy of mycobacterial infections
Full text linkThe mechanism of action of many antimycobacterial agents is poorly understood. To
obtain preliminary information on whether the targets for some of these drugs
might also occur in other bacteria, the in vitro activities of selected agents
against Escherichia coli, Bacillus subtilis and Staphylococcus aureus were
determined. Dapsone, p-aminosalicylic acid and thiacetazone failed to inhibit the
above organisms (MIC values > 100 micrograms/ml) that may therefore lack targets
for these drugs. Capreomycin, viomycin and clofazimine demonstrated activity
against some of the organisms (MIC values < 100 micrograms/ml) suggesting that
the targets of these drugs may not be restricted to mycobacterial species. The
agents were all potent inhibitors of Mycobacterium bovis bacille Calmette-Guéri
Studio sull'attività di associazione di antibiotici betalattamici su beta lattamasi prodotte da ceppi di Enterobacteriaceae
No full textattività antibatterica in vitro e in vivo dell'associazione cefaloridina dicloxacillina nel rapporto 2:1
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in vitro and in vivo antibacterial activity of bacampicillin, a new prodrug of ampicillin
No full textIn vitro and in vivo microbiological evaluations of cefoperazone
No full textEvaluations of minimum inhibitory concentrations MICs) were carried out with cefoperazone on 35 gram-positive, 60 gram-negative, and 64 anaerobic strains. Results were compared to those obtained with cefuroxime, cefoxitin, cephaloridine, cefazolin, cephalexin and (for the anaerobic bacteria only) cephalothin. In vitro activity of cefoperazone was excellent against strains of Streptococcus faecalis (MICs between 6.25 and 12.5 μg/ml) and Staphylococcus aureus (100% of the tested strains were inhibited by ≤ 12.5 μg/ml). Cefoperazone activity against gram-negative strains was superior to that of all the other cephalosporins tested. It is noteworthy that all of the Proteus species and Pseudomonas aeruginosa strains were inhibited by ≤ 50 μg/ml cefoperazone, a level readily achievable in serum with normal dosages. All Escherichia coli were inhibited by ≤ 1.56 μg/ml. In vitro activity of cefoperazone was extremely high against anaerobic bacteria: 100% of the strains tested were susceptible at ≤ 1.56 μg/ml. The PD50 values in experimental infections in mice confirmed the high in vitro activity of cefoperazone, with lower doses required for protection than for the other cephalosporins tested. This may be due to the favorable pharmacokinetics of cefoperazone. The stability of cefoperazone in the presence of beta-lactamase was also confirmed
Comparative study of serum and tissue levels after administration of sisomicin and gentamicin
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