14 research outputs found
Report on Housing Credit and Financing in Addis Ababa.
No full textResearch on the housing situation of Addis Ababa, Ethiopia, conducted as part of the studies commissione by the Department of International Cooperation of the Italian Ministry of Foreign Affairs for the new Master Plan of the city of Addis Ababa. This study was written in English by the Author and published in the document series of the new master plan by AAMPPO-Addis Ababa Master Plan Project Office
Occupancy Grid Mapping with Cognitive Plausibility for Autonomous Driving Applications
No full textThis work investigates the validity of an occupancy grid mapping inspired by human cognition and the way humans visually perceive the environment. This query is motivated by the fact that, to date, no autonomous driving system reaches the performance of an ordinary human driver. The mechanisms behind human perception could provide cues on how to improve common techniques employed in autonomous navigation - specifically the use of occupancy grids to represent the environment. We experiment with a neural network that maps an image of the scene onto an occupancy grid representation, and we show how the model benefits from two key (and yet simple) changes: 1) a different format of occupancy grid that resembles the way the brain projects the environment into a warped representation in the cortical visual area; 2) a mechanism similar to human visual attention that filters out non-relevant information from the scene. These effective expedients can potentially be applied to any autonomous driving task requiring an abstract representation of the scenario like the occupancy grids. Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Intelligent Vehicle
Le Scuole Piccole nella Venezia dei Dogi. Note d’archivio per la storia delle confraternite veneziane
No full textSYNTHESIS OF C-GLYCOSYL AMINO ACIDS AS STABLE BUILDING BLOCKS FOR MODIFIED GLYCOPEPTIDE SYNTHESIS
No full textIn this thesis, we have studied and synthesized new class of C-glycosly amino acids whose structure features a
hetrocycle ring holding the carbohydrate and the amino acid fragments. Pyridine and tetrazole rings were used as
hetrocycle linkers in this project. This class of C-glycosyl amino acids is of interest as new chealtors and as building
building blocks for cotranslational glycopeptides synthesis. In the first part, C-Glycosylmethyl pyridylalanines were
synthesized via thermally induced Hantzsch-type cyclocondensation using an aldehyde-ketoester-enamino ester system.
To one of these reagents was attached a C-glycosyl residue, while to another was bound an amino acid fragment. In a
one-pot optimized methodology, the dihydropyridine was not isolated while its purification was carried out by removal
of unreacted material and side products using polymer-supported scavengers. Then the dihydropyridine (mixture of
diastereoisomers) was oxidized by a polymer-bound oxidant to give the target pyridine bearing the two bioactive
residues. In this way, a range of eight compounds (58-68% yield) was prepared in which the elements of diversity were
(i) the gluco and galacto configurations of the pyranose ring, (ii) the α- and β-configurations at the anomeric center, and
(iii) the positions of the carbohydrate and amino acid sectors in the pyridine ring. The orthogonal functional group
protection in these amino acids allowed their easy incorporation into oligopeptides via sequential amino and carboxylic
group coupling.
In the second part, tetrazole moiety was constructed via Huisgen 1,3-dipolar cycloaddition between nitriles and organic
azides. Two sets of compounds have been prepared, one being constituted of C-galactosyl and C-ribosyl O-tetrazolyl
serines, while the other contains S-tetrazolyl cysteine derivatives. In both cases, the synthetic scheme involved a twostep
route: the first one being the thermal cycloaddition of a sugar azide with p-toluensulfonyl cyanide (TsCN) to give a
1-substituted 5-sulfonyl tetrazole and the second the replacement of the tosyl group with a serine or cysteine residue.
For the high efficiency and operational simplicity, the azide-TsCN cycloaddition appears to be a true click process.
Finally, one of the amino acids prepared was incorporated into a tripeptid
Increased number of thromboxane A2-prostaglandin H2 platelet receptors in active unstable angina and causative role of enhanced thrombin formation
No full textThe Florentine House of Medici (1389-1743): politics, patronage, and the use of cultural heritage in shaping the Renaissance
No full textA great many individuals and families of historical prominence contributed to the development of the Italian and larger European Renaissance through acts of patronage. Among them was the Florentine House of Medici. The Medici were an Italian noble house that served first as the de facto rulers of Florence, and then as Grand Dukes of Tuscany, from the mid-15th century to the mid-18th century. This thesis evaluates the contributions of eight consequential members of the Florentine Medici family, Cosimo di Giovanni, Lorenzo di Giovanni, Giovanni di Lorenzo, Cosimo I, Cosimo II, Cosimo III, Gian Gastone, and Anna Maria Luisa, and their acts of artistic, literary, scientific, and architectural patronage that contributed to the cultural heritage of Florence, Italy. This thesis also explores relevant social, political, economic, and geopolitical conditions over the course of the Medici dynasty, and incorporates primary research derived from a conversation and an interview with specialists in Florence in order to present a more contextual analysis. Further analysis examines how the Medici successfully used knowledge and beliefs concerning the past, as well as contemporary Florentine culture to advance themselves and cement their legacy. Historical parallels are also explored. Existing literature makes plain that the Medici contributed a great deal to the Renaissance movement through their acts of patronage. This thesis contributes an original perspective to existing literature by concluding that the House of Medici largely shaped, and ultimately epitomizes the Renaissance itself through its contributions to Florentine cultural heritage, and by historic preservation efforts that define how we understand the Renaissance today. Justification for this conclusion is supported by the International Council on Monuments and Sites (ICOMOS) Advisory Body Evaluation, which cites Medici contributions to the cultural heritage of Florence and the Renaissance in support of the United Nations Educational, Scientific and Cultural Organization (UNESCO) designation of the Historic Centre of Florence as a World Heritage Site. The lesson learned is that the cultural heritage of the world is priceless, but it is nothing without measures taken to ensure its protection.M.A.Includes bibliographical referencesby Nicholas J. Cuozz
Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 receptor inhibitor
No full text
