186,181 research outputs found
Persistence of a P3 component in severe amnestic syndrome
No full textEvent-related potentials (ERPs) to an odd-ball paradigm were recorded from 19 scalp derivations in a patient (47 years old, housewife) affected by complete amnestic syndrome following limbic encephalitis. CT scans and magnetic resonance imaging showed severe bilateral lesions of anterior, mid-temporal lobes and frontal lobes. A P3 component, with a peak latency inside normal limits for age-matched controls, was recorded to 'target' stimuli from all leads except Fp1, Fp2, F7, F8, T3 and T4
Feasibility Study for the Development of a Novel Reusable Crash Absorber Based on a Negative Stiffness Structure
No full textBusiness Intelligence for SMEs: a hybrid review of models, barriers, and future directions
No full textThis study examines how Business Intelligence (BI) is conceptualised, adopted, and implemented within Small and Medium-sized Enterprises (SMEs), a context where digital transformation is essential yet insufficiently explored. Although BI is widely recognised as a strategic driver of informed decision-making and competitiveness, existing research remains fragmented and often sector-specific. Using a hybrid methodology that combines bibliometric analysis with a qualitative systematic literature review from 2015 to 2024, the study traces a shift from early semantic and dashboard-driven models to cloud-based, predictive solutions. It also identifies key limitations and proposes future research on empirical validation, adaptable governance, and innovation-resource trade-offs
Hemiptera and Coleoptera on Chenopodium quinoa
No full textHeteroptera and Coleoptera, collected in experimental fields of Chenopodium quinoa, are reported. Twelve
species of Heteroptera and five species of Coleoptera were recorded; a large number of the phytophagous species, Lygus
rugulipennis, Orthotylus flavosparsus, Aphis craccivora, A. fabae and Chaetocnema tibialis, and of the predator
Hippodamia variegata were found
Dario Fo e la «pancera flanellata»: scheda linguistica su Aveva due pistole con gli occhi bianchi e neri
No full text
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
P-cresol alters brain dopamine metabolism and exacerbates autism-like behaviors in the BTBR mouse
No full textBackground: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction/communication, stereotypic behaviors, restricted interests, and abnormal sensory-processing. Several studies have reported significantly elevated urinary and foecal levels of p-cresol in ASD children, an aromatic compound either of environmental origin or produced by specific gut bacterial strains. Methods: Since p-cresol is a known uremic toxin, able to negatively affect multiple brain functions, the present study was undertaken to assess the effects of a single acute injection of low- or high-dose (1 or 10 mg/kg i.v. respectively) of p-cresol in behavioral and neurochemical phenotypes of BTBR mice, a reliable animal model of human ASD. Results: P-cresol significantly increased anxiety-like behaviors and hyperactivity in the open field, in addition to producing stereotypic behaviors and loss of social preference in BTBR mice. Tissue levels of monoaminergic neurotransmitters and their metabolites unveiled significantly activated dopamine turnover in amygdala as well as in dorsal and ventral striatum after p-cresol administration; no effect was recorded in medial-prefrontal cortex and hippocampus. Conclusion: Our study supports a gene x environment interaction model, whereby p-cresol, acting upon a susceptible genetic background, can acutely induce autism-like behaviors and produce abnormal dopamine metabolism in the reward circuitry
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