1,721,015 research outputs found
Surfactant disaturated-phosphatidylcholine turnover and pool size in humans with ARDS
No full textI.F. 4,00
Prognostic role of somatosensory and auditory evoked potentials in paediatric hypoxic-ischemic encephalopathy managed with hypothermia: An illustrative case
No full textntroduction: The contribution of clinical neurophysiology in the neurological prognosis of hypoxic-ischemic coma has been well established in adults: the bilateral absence of cortical somatosensory evoked potentials (SEP) is considered the single best indicator of adverse outcome, while the presence of the auditory mismatch negativity (MMN) is thought to herald arousal. Study aim: To use MMN combined with serial EEG recordings, somatosensory and brainstem auditory evoked potentials (BAEP) in a paediatric case of postanoxic coma managed with hypothermia, since they have not yet been described in children. Methods: We report the case of a nine-year-old boy with hypoxic-ischemic encephalopathy due to cardiorespiratory arrest after accidental burial in sand, who was treated with therapeutic hypothermia for 72 hours. Serial EEG recordings, evoked potentials, brain CT scan and brain MRI were performed in the first few days after the event. Results: SEP to median nerve stimulation showed bilateral absence of the N20 component, while the N13 and P14 peaks were preserved; BAEP showed normal I-V interpeak latency and normal hearing threshold. At the same time, the MMN component of auditory event related potentials, recorded in the classical oddball paradigm, was absent. Seventeen months after the accident, the patient is alive in persistent vegetative state. Conclusions: This case illustrates the particular significance of SEP and MMN together with EEG in gaining prognostic information, even in sedated and hypothermic patients, and encourages systematic study of these prognostic tools in paediatric postanoxic coma
MEASUREMENT OF PULMONARY SURFACTANT DISATURATED-PHOSPHATIDYLCHOLINE SYNTHESIS IN HUMAN INFANTS USING DEUTERIUM INCORPORATION FROM BODY WATER
No full textPULMONARY SURFACTANT DISATURATED-PHOSPHATIDYLCOLINE (DSPC)TURNOVER AND POOL SIZE IN NEWBORN INFANTS WITH CONGENITAL DIAPHRAGMATIC HERNIA (CDH)
No full textSURFACTANT DISATURATED-PHOSPHATIDYLCHOLINE KINETICS IN INFANTS WITH BRONCHOPULMONARY DYSPLASIA MEASURED WITH STABLE ISOTOPES AND A TWO COMPARTMENT MODEL
No full textSurfactant protein C metabolism in human infants and adult patients by stable isotope tracer and mass spectrometry.
No full textSurfactant protein C (SP-C) is deemed as the surfactant protein most specifically expressed in type II alveolar epithelial cells and plays an important role in surfactant function. SP-C turnover in humans and its meaning in the clinical context have never been approached. In this study, we used mass spectrometry to investigate SP-C turnover in humans. We studied four infants and eight adults requiring mechanical ventilation. All patients had no lung disease. Patients received a 24-h continuous infusion of (13)C-leucine as precursor of SP-C, and serial tracheal aspirates and plasma samples were obtained every 6 h till 48 h. SP-C was isolated from tracheal aspirates by sorbent-phase chromatography. (13)C-leucine SP-C enrichment could be successfully measured in three infant and in four adult samples by using mass spectrometry coupled with a gas chromatographer. Median SP-C fractional synthesis rate, secretion time, and peak time were 15.7 (14.1-27.5)%/day, 6.0 (4.7-11.5) h, and 24 (20-27) h. In conclusion, this study shows that it is feasible to accurately determine SP-C turnover in humans by stable isotopes
SURFACTANT PHOSPHATIDYLCHOLINE HALF-LIFE AND POOL SIZE MEASUREMENTS IN PREMATURE BABOONS DEVELOPING BRONCHOPULMONARY DYSPLASIA
No full textA DUAL STABLE ISOTOPE TRACER METHOD FOR THE MEASUREMENT OF SURFACTANT DISATURATED-PHOSPHATIDYLCOLINE NET SYNTESIS IN INFANTS WITH CONGENITAL DIAPHRAGMATIC HERNIA.
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