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Somatosympathetic reflexes are enhanced in insulin resistant, hyperinsulinaemic Zucker rats
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Minimal model based assessment of insulin resistance in relation to body weight in the Zucker fatty rat
No full textEnhanced beta-cell secretion in the zucker fatty rat assessed by minimal modeling of intravenous C-peptide data
No full textComparison of minimal model based estimates of insulin sensitivity and glucose effectiveness in SHR and WKY rats
No full textProceedings of the Chicago 2000 World Congress on Medical Physics and Biomedical Engineering, Chicago, I
Minimal model analysis of glucose kinetics in young homozygote and heterozygote Zucker rats
No full textExperimental Biology 2005. XXXV International Congress of Physiological Sciences. San Diego, CA
Age-related analysis of insulin resistance, body weight and arterial pressure in the Zucker fatty rat
No full textThe evolution with ageing of insulin resistance, body weight (BW) and mean arterial pressure (MAP) was studied in a group of Zucker fatty rats (ZFRs, n =22), between 7 and 16 weeks of age, compared with an age-matched control group of Zucker lean rats (ZLRs, n =22). The minimal model of glucose kinetics was applied to estimate glucose effectiveness, SG, and insulin sensitivity, SI, frominsulinaemia and glycaemia measuredduring a 70 minintravenous glucose tolerance test. No correlation was found between SG and age in both ZFR and ZLR groups. No significant changes in mean SG between the two groups indicated no alteration of glucose-mediated glucose disposal. Estimates of SI from individual ZFRs were independent of age and, on average, showed 83% reduction (P <0.001) compared with the ZLR group. Despite the lack of alteration of SI with age, the ZFR group showed an age-related increase of MAP, which correlated with increasing BW(r =0.71 and P <0.001). These results support the hypothesis that in our ZFRs, as a suitable genetic model of obesity and hypertension, insulin resistance is fully established at the age of 7 weeks and remains practically unaltered until at least the sixteenth week. An age-related increase in arterial pressure, observed in this strain, relates more properly to increasing BW, rather than insulin resistance. Development of hypertension with increasing age and BW may result from an enhanced insulin-mediated activity of the sympathetic nervous system, as observed in our previously reported study
Severe insulin resistance does not associate with hypertension in the young homozygote Zucker rat
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Age-related analysis of glucose metabolism in spontaneously hypertensive and normotensive rats
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